Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.32 |
| ▸ | ATIC | P31939 | 1/20 | 0.32 |
| ▸ | GDA | Q9Y2T3 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL856432 | 0.72 | ALDH1A1 (0.39) | ALDH1A1 | |
| SCHEMBL3670371 | 0.68 | ALDH1A1 (0.32) | ALDH1A1POLBRXFP1 | |
| SCHEMBL4371910 | 0.63 | — | — | |
| SCHEMBL14570099 | 0.63 | IDO1 (0.35) | — | |
| SCHEMBL1437156 | 0.62 | ALDH1A1 (0.36) | ALDH1A1 | |
| SCHEMBL7419568 | 0.60 | CA9 (0.38) | ALDH1A1 | |
| SCHEMBL1980269 | 0.60 | — | — | |
| SCHEMBL856431 | 0.60 | ALDH1A1 (0.30) | ALDH1A1 | |
| SCHEMBL7018235 | 0.60 | ALDH1A1 (0.39) | ALDH1A1 | |
| SCHEMBL1551085 | 0.59 | S100A4 (0.41) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2240485-A1 | TRICYCLIC COMPOUNDS HAVING CORTICOTROPIN-RELEASING FACTOR ANTAGONISTIC ACTIVITY AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Takeda Pharmaceutical Company Limited (JP) | 2010-10-20 | — | — | EP | disclosed |
| WO-2009093747-A1 | TRICYCLIC COMPOUNDS HAVING CORTICOTROPIN-RELEASING FACTOR ANTAGONISTIC ACTIVITY AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-07-30 | — | — | WO | disclosed |