Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | GALR3 | O60755 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | PARP14 | Q460N5 | 2/20 | 0.40 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 4/20 | 0.40 |
| ▸ | CDK1 | P06493 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.39 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.39 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.38 |
| ▸ | NR3C1 | P04150 | 6/20 | 0.37 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.37 |
| ▸ | PGR | P06401 | 4/20 | 0.36 |
| ▸ | NR3C2 | P08235 | 4/20 | 0.36 |
| ▸ | AR | P10275 | 4/20 | 0.36 |
| ▸ | PGAM1 | P18669 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3681528 | 0.78 | MCL1 (0.46) | ALDH1A1KDM4EHPGDGALR3GAA | |
| SCHEMBL3667719 | 0.77 | HTT (0.49) | ALDH1A1KDM4EHPGDGALR3GAA | |
| SCHEMBL6695728 | 0.75 | MCL1 (0.45) | ALDH1A1KDM4EHPGDGALR3GAA | |
| SCHEMBL3672345 | 0.73 | KDM4E (0.43) | ALDH1A1KDM4EHPGDGALR3GAA | |
| SCHEMBL6695575 | 0.73 | KDM4E (0.51) | ALDH1A1KDM4EHPGDGALR3GAA | |
| SCHEMBL3676539 | 0.73 | MCL1 (0.43) | ALDH1A1KDM4EHPGDGALR3GAA | |
| Water SCHEMBL4777584 | 0.73 | GRIA1 (0.47) | ALDH1A1KDM4EHPGDGALR3GAA | |
| SCHEMBL2918049 | 0.73 | GRIA1 (0.47) | ALDH1A1KDM4EHPGDGALR3GAA | |
| SCHEMBL3677714 | 0.72 | TGFBR1 (0.42) | ALDH1A1KDM4EHPGDGALR3GAA | |
| SCHEMBL3976737 | 0.72 | MCL1 (0.44) | ALDH1A1KDM4EHPGDGAAMCL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2254577-A1 | AMPA RECEPTOR ANTAGONISTS FOR EPILEPSY, MENTAL DISORDERS OR DEFICITS IN SENSORY ORGAN | Eisai R&D Management Co., Ltd. (JP) | 2010-12-01 | — | — | EP | disclosed |
| EP-2164489-A2 | COMBINATION OF AMPA RECEPTOR ANTAGONISTS AND ACETYLCHOLINESTERASE INHIBITORS FOR THE TREATMENT OF NEUROPATHIC PAIN | Eisai R&D Management Co., Ltd. (JP) | 2010-03-24 | — | — | EP | disclosed |
| EP-2131828-A2 | AMPA AND NMDA RECEPTOR ANTAGONISTS FOR NEURODEGENERATIVE DISEASES | Eisai R&D Management Co., Ltd. (JP) | 2009-12-16 | — | — | EP | disclosed |
| WO-2009082039-A1 | AMPA RECEPTOR ANTAGONISTS FOR EPILEPSY, MENTAL DISORDERS OR DEFICITS IN SENSORY ORGAN | EISAI R & D MANAGEMENT CO., LTD. (JP) | 2009-07-02 | — | — | WO | disclosed |
| WO-2009054543-A1 | AMPA RECEPTOR ANTAGONISTS AND ZONISAMIDE FOR PARKINSON'S DISEASE AND MOVEMENT DISORDERS | EISAI R & D MANAGEMENT CO., LTD. (JP) | 2009-04-30 | — | — | WO | disclosed |
| WO-2009054544-A1 | AMPA RECEPTOR ANTAGONISTS FOR PARKINSON'S DISEASE AND MOVEMENT DISORDERS | EISAI R & D MANAGEMENT CO., LTD. (JP) | 2009-04-30 | — | — | WO | disclosed |
| WO-2009011412-A2 | COMBINATION OF AMPA RECEPTOR ANTAGONISTS AND ACETYLCHOLINESTERASE INHIBITORS FOR THE TREATMENT OF NEUROPATHIC PAIN | EISAI R & D MANAGEMENT CO., LTD. (JP) | 2009-01-22 | — | — | WO | disclosed |
| WO-2008111590-A2 | AMPA AND NMDA RECEPTOR ANTAGONISTS FOR NEURODEGENERATIVE DISEASES | EISAI R & D MANAGEMENT CO., LTD. (JP) | 2008-09-18 | — | — | WO | disclosed |