Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 5/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | CASP6 | P55212 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.41 |
| ▸ | PIN1 | Q13526 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
| ▸ | MTOR | P42345 | 1/20 | 0.39 |
| ▸ | ADK | P55263 | 1/20 | 0.39 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.39 |
| ▸ | DCUN1D1 | Q96GG9 | 2/20 | 0.38 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.38 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.38 |
| ▸ | BTK | Q06187 | 1/20 | 0.38 |
| ▸ | TNKS | O95271 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3933282 | 0.79 | HPGDS (0.37) | MEN1KMT2AMAPTKDM4ECASP6 | |
| SCHEMBL528246 | 0.72 | MEN1 (0.46) | MEN1KMT2AMAPTKDM4ECYP1A2 | |
| SCHEMBL27840974 | 0.71 | MTOR (0.42) | MEN1KMT2AKDM4ECYP1A2CYP2C19 | |
| SCHEMBL2094094 | 0.71 | MTOR (0.42) | MEN1KMT2AMAPTKDM4ECYP1A2 | |
| SCHEMBL27456927 | 0.71 | MTOR (0.42) | MEN1KMT2AMAPTKDM4ECYP1A2 | |
| SCHEMBL1954237 | 0.71 | MTOR (0.42) | MEN1KMT2AMAPTKDM4ECYP1A2 | |
| SCHEMBL637805 | 0.71 | ALDH1A1 (0.48) | MEN1KMT2AMAPTKDM4ECYP1A2 | |
| SCHEMBL3122569 | 0.71 | MTOR (0.42) | MEN1KMT2AMAPTKDM4ECYP1A2 | |
| SCHEMBL57159 | 0.71 | NR1H2 (0.45) | MEN1KMT2AMAPTKDM4ECYP1A2 | |
| SCHEMBL49612 | 0.71 | GAA (0.52) | MEN1KMT2AMAPTKDM4ECYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1244460-B8 | USE OF DIPYRIDINIUM COMPOUNDS FOR TREATING A DISEASE CHARACTERIZED BY PROLIFERATING CELLS CONTAINING NITRIC OXIDE SYNTHASE | UNIV DUKE (US) | 2010-05-19 | — | — | EP | disclosed |
| EP-1244460-A4 | TREATMENTS BASED ON DISCOVERY THAT NITRIC OXIDE SYNTHASE IS A PARAQUAT DIAPHORASE | UNIV DUKE (US) | 2004-10-06 | — | — | EP | disclosed |
| EP-1244460-A1 | TREATMENTS BASED ON DISCOVERY THAT NITRIC OXIDE SYNTHASE IS A PARAQUAT DIAPHORASE | DUKE UNIVERSITY (US) | 2002-10-02 | — | — | EP | disclosed |
| WO-2001028568-A1 | TREATMENTS BASED ON DISCOVERY THAT NITRIC OXIDE SYNTHASE IS A PARAQUAT DIAPHORASE | DUKE UNIVERSITY (US) | 2001-04-26 | — | — | WO | disclosed |