SCHEMBL7573786

SCHEMBL7573786

COc1ccc(Cl)c(Nc2ncnc3cc(OCc4ccccc4)c(OC)cc23)c1

nearest known ligand 0.80

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
SRC P12931 6/20 0.80
KDR P35968 9/20 0.67
RET P07949 1/20 0.66
KIF5B P33176 1/20 0.66
EGFR P00533 8/20 0.60
EPHA2 P29317 4/20 0.60
ERBB2 P04626 3/20 0.60
MAPK14 Q16539 1/20 0.59
EPHB4 P54760 3/20 0.58
FLT1 P17948 2/20 0.58
HTT P42858 2/20 0.58
KDM4E B2RXH2 1/20 0.58
LMNA P02545 1/20 0.58
HPGD P15428 1/20 0.58
RIPK2 O43353 1/20 0.58
NOD1 Q9Y239 1/20 0.58
LCK P06239 1/20 0.57

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7572116 0.88 EGFR (0.66) SRCKDRRETEGFRERBB2
SCHEMBL7574178 0.82 SRC (0.77) SRCKDRRETKIF5BEGFR
Hydrochloric Acid SCHEMBL2455762 0.82 EGFR (0.66) KDRRETKIF5BEGFREPHA2
SCHEMBL30891782 0.82 EGFR (0.83) SRCKDRRETKIF5BEGFR
SCHEMBL7580350 0.82 SRC (0.76) SRCKDRRETKIF5BEGFR
SCHEMBL7580342 0.82 SRC (0.76) SRCKDRRETKIF5BEGFR
SCHEMBL7572205 0.82 SRC (0.76) SRCKDRRETKIF5BEGFR
Hydrochloric Acid SCHEMBL3276171 0.81 SRC (0.70) SRCKDREGFRERBB2HPGD
SCHEMBL18979021 0.81 FLT1 (0.84) SRCKDREGFRFLT1
SCHEMBL4985763 0.81 EGFR (0.66) SRCKDRRETKIF5BEGFR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0904769-B1 Keratin fibre dye compositions containing Indazole amine derivatives and dyeing method OREAL (FR) 2002-09-25 EP claimed
US-6027538-A OXIDATION DYEING OF KERATINOUS FIBERS CONTAINING AT LEAST ONE COUPLER SELECTED FROM INDAZOLEAMINE DERIVATIVES AND AT LEAST ONE OXIDATION BASE; POWERFUL, NOT VERY SELECTIVE HAIR DYES WHICH ARE CAPABLE OF GENERATING INTENSE COLOR L'OREAL S.A. (FR) 2000-02-22 US claimed
WO-2002092577-A1 QUINAZOLINE DERIVATIVES ASTRAZENECA AB (SE) 2002-11-21 WO disclosed
WO-2002092579-A1 4-ANILINOQUINAZOLINE DERIVATIVES ASTRAZENECA AB (SE) 2002-11-21 WO disclosed
US-6027538-A OXIDATION DYEING OF KERATINOUS FIBERS CONTAINING AT LEAST ONE COUPLER SELECTED FROM INDAZOLEAMINE DERIVATIVES AND AT LEAST ONE OXIDATION BASE; POWERFUL, NOT VERY SELECTIVE HAIR DYES WHICH ARE CAPABLE OF GENERATING INTENSE COLOR L'OREAL S.A. (FR) 2000-02-22 US disclosed