Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 19/20 | 0.33 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL841511 | 0.81 | SCN9A (0.35) | — | |
| Ammonia Solution, Strong SCHEMBL3673475 | 0.81 | SCN9A (0.35) | — | |
| SCHEMBL3668938 | 0.80 | NPC1 (0.37) | DPP4 | |
| SCHEMBL3674446 | 0.77 | IDO1 (0.38) | — | |
| SCHEMBL3667284 | 0.76 | KCNH2 (0.46) | DPP4 | |
| SCHEMBL3668903 | 0.75 | SCN9A (0.41) | DPP4 | |
| SCHEMBL3674960 | 0.71 | CYP11B1 (0.33) | DPP4GPBAR1 | |
| SCHEMBL3672812 | 0.70 | KCNH2 (0.38) | DPP4 | |
| SCHEMBL841172 | 0.70 | — | — | |
| SCHEMBL3672628 | 0.68 | SCN9A (0.41) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2158198-A2 | NOVEL N- (8HETEROARYLTETRAHYDRONAPHTALENE-2YL) OR N- (5- HETEROARYLCHROMANE-3-YL) CARBOXAMIDE DERIVATIVES FOR THE TREATMENT OF PAIN | AstraZeneca AB (SE) | 2010-03-03 | — | — | EP | disclosed |
| WO-2008130320-A2 | NOVEL N- (8-HETEROARYLTETRAHYDRONAPHTALENE-2YL) OR N- (5- HETEROARYLCHROMANE-3-YL) CARBOXAMIDE DERIVATIVES FOR THE TREATMENT OF PAIN | ASTRAZENECA AB (SE) | 2008-10-30 | — | — | WO | disclosed |