Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.38 |
| ▸ | DPP4 | P27487 | 2/20 | 0.32 |
| ▸ | EED | O75530 | 1/20 | 0.32 |
| ▸ | SUZ12 | Q15022 | 1/20 | 0.32 |
| ▸ | EZH2 | Q15910 | 1/20 | 0.32 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.31 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.31 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.31 |
| ▸ | MAOB | P27338 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3668903 | 0.86 | SCN9A (0.41) | KCNH2SCN5ASCN9ADPP4EED | |
| SCHEMBL3673795 | 0.86 | DHFR (0.33) | KCNH2SCN5ASCN9ADPP4 | |
| SCHEMBL3672940 | 0.84 | DHFR (0.33) | DPP4 | |
| SCHEMBL3676949 | 0.79 | SCN9A (0.38) | KCNH2SCN5ASCN9ADPP4PIK3CD | |
| SCHEMBL839850 | 0.78 | SCN9A (0.46) | KCNH2SCN5ASCN9AEEDSUZ12 | |
| SCHEMBL3672628 | 0.78 | SCN9A (0.41) | KCNH2SCN5ASCN9A | |
| SCHEMBL3670227 | 0.78 | JAK3 (0.33) | DPP4 | |
| SCHEMBL3667284 | 0.78 | KCNH2 (0.46) | KCNH2SCN5ASCN9ADPP4PIK3CA | |
| Ammonia Solution, Strong SCHEMBL3672811 | 0.77 | SCN9A (0.46) | KCNH2SCN5ASCN9AEEDSUZ12 | |
| SCHEMBL3674960 | 0.76 | CYP11B1 (0.33) | DPP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2158198-A2 | NOVEL N- (8HETEROARYLTETRAHYDRONAPHTALENE-2YL) OR N- (5- HETEROARYLCHROMANE-3-YL) CARBOXAMIDE DERIVATIVES FOR THE TREATMENT OF PAIN | AstraZeneca AB (SE) | 2010-03-03 | — | — | EP | disclosed |
| WO-2008130320-A2 | NOVEL N- (8-HETEROARYLTETRAHYDRONAPHTALENE-2YL) OR N- (5- HETEROARYLCHROMANE-3-YL) CARBOXAMIDE DERIVATIVES FOR THE TREATMENT OF PAIN | ASTRAZENECA AB (SE) | 2008-10-30 | — | — | WO | disclosed |