Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTHFD2 | P13995 | 8/20 | 0.44 |
| ▸ | SPR | P35270 | 4/20 | 0.40 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.38 |
| ▸ | TNKS | O95271 | 3/20 | 0.38 |
| ▸ | TNKS2 | Q9H2K2 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1622911 | 0.85 | OPRD1 (0.44) | MTHFD2SPRTNKS2TSHR | |
| SCHEMBL26672635 | 0.82 | MTHFD2 (0.45) | MTHFD2SPRDGAT2 | |
| SCHEMBL28933182 | 0.82 | MTHFD2 (0.44) | MTHFD2SPRTNKS2KDM4E | |
| SCHEMBL23973019 | 0.82 | MTHFD2 (0.46) | MTHFD2KMT2A | |
| SCHEMBL23973058 | 0.81 | MTHFD2 (0.46) | MTHFD2SPRDGAT2 | |
| SCHEMBL26672673 | 0.81 | MTHFD2 (0.46) | MTHFD2SPRDGAT2 | |
| SCHEMBL26669681 | 0.80 | MTHFD2 (0.45) | MTHFD2SPR | |
| SCHEMBL28933168 | 0.80 | MTHFD2 (0.45) | MTHFD2SPR | |
| SCHEMBL26672633 | 0.80 | MTHFD2 (0.45) | MTHFD2SPRDGAT2 | |
| SCHEMBL26672585 | 0.80 | MTHFD2 (0.45) | MTHFD2SPR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2139896-A1 | PYRIMIDO [4, 5-D]AZEPINE DERIVATIVES AS 5-HT2C AGONISTS | Pfizer Limited (GB) | 2010-01-06 | — | — | EP | disclosed |
| WO-2008117169-A1 | PYRIMIDO [4, 5-D] AZEPINE DERIVATIVES AS 5-HT2C AGONISTS | PFIZER LIMITED (GB) | 2008-10-02 | — | — | WO | disclosed |