Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 16/20 | 0.74 |
| ▸ | LMNA | P02545 | 1/20 | 0.62 |
| ▸ | POLB | P06746 | 1/20 | 0.62 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.62 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.62 |
| ▸ | NPC1 | O15118 | 2/20 | 0.55 |
| ▸ | RAB9A | P51151 | 2/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL602088 | 0.85 | DGAT1 (1.00) | DGAT1 | |
| SCHEMBL3671454 | 0.79 | DGAT1 (0.69) | DGAT1POLBNPC1RAB9A | |
| SCHEMBL3668679 | 0.77 | DGAT1 (0.71) | DGAT1LMNAPOLBNPC1RAB9A | |
| SCHEMBL3670069 | 0.75 | DGAT1 (0.72) | DGAT1POLBNPC1RAB9A | |
| SCHEMBL3671390 | 0.74 | CSNK2A2 (0.65) | DGAT1TDP1NPC1RAB9A | |
| SCHEMBL3679276 | 0.73 | DGAT1 (0.76) | DGAT1 | |
| SCHEMBL3673344 | 0.72 | DGAT1 (0.76) | DGAT1NPC1RAB9A | |
| SCHEMBL3668829 | 0.72 | DGAT1 (0.74) | DGAT1POLBTDP1NPC1RAB9A | |
| SCHEMBL3674889 | 0.71 | DGAT1 (0.76) | DGAT1POLBL3MBTL1NPC1RAB9A | |
| SCHEMBL3666190 | 0.71 | DGAT1 (0.57) | DGAT1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2391611-A1 | THIADIAZOLE AND OXADIAZOLE DERIVATIVES, PREPARATION THEREOF, AND THERAPEUTIC USE THEREOF | SANOFI (FR) | 2011-12-07 | — | — | EP | claimed |
| WO-2010086551-A1 | THIADIAZOLE AND OXADIAZOLE DERIVATIVES, PREPARATION THEREOF, AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2010-08-05 | — | — | WO | claimed |
| EP-2391611-A1 | THIADIAZOLE AND OXADIAZOLE DERIVATIVES, PREPARATION THEREOF, AND THERAPEUTIC USE THEREOF | SANOFI (FR) | 2011-12-07 | — | — | EP | disclosed |
| WO-2010086551-A1 | THIADIAZOLE AND OXADIAZOLE DERIVATIVES, PREPARATION THEREOF, AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2010-08-05 | — | — | WO | disclosed |