SCHEMBL3674343

SCHEMBL3674343

NC(N)c1c(F)ccc2ccccc12

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.44
HSD17B10 Q99714 4/20 0.44
TSHR P16473 3/20 0.44
CYP2A6 P11509 3/20 0.44
TDP1 Q9NUW8 1/20 0.44
HPRT1 P00492 3/20 0.44
CYP1B1 Q16678 2/20 0.38
HIF1A Q16665 1/20 0.38
NPC1 O15118 2/20 0.38
L3MBTL1 Q9Y468 2/20 0.38
KDM4E B2RXH2 2/20 0.38
MAPT P10636 2/20 0.38
MAPK1 P28482 1/20 0.38
HPGD P15428 2/20 0.37
CYP3A4 P08684 1/20 0.37
KEAP1 Q14145 1/20 0.37
MEN1 O00255 2/20 0.35
KMT2A Q03164 2/20 0.35
RAB9A P51151 1/20 0.35
CYP1A2 P05177 2/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4569234 0.79 NCEH1 (0.45) ALDH1A1HSD17B10TSHRCYP2A6TDP1
SCHEMBL19682791 0.78 HPRT1 (0.42) ALDH1A1HSD17B10TSHRCYP2A6TDP1
SCHEMBL8375012 0.76 HPRT1 (0.41) ALDH1A1HSD17B10TSHRCYP2A6TDP1
SCHEMBL3670212 0.75 ALDH1A1 (0.44) ALDH1A1HSD17B10TSHRCYP2A6TDP1
SCHEMBL3673586 0.75 CYP2A6 (0.54) ALDH1A1HSD17B10TSHRCYP2A6TDP1
SCHEMBL19682748 0.73 AKR1C3 (0.42) ALDH1A1NPC1L3MBTL1KDM4EMAPT
SCHEMBL20889374 0.73 AKR1C3 (0.42) ALDH1A1NPC1L3MBTL1KDM4EMAPT
SCHEMBL12511087 0.73 HTR2A (0.48) ALDH1A1HSD17B10TSHRCYP2A6TDP1
SCHEMBL5694926 0.71 ALDH1A1 (0.50) ALDH1A1HSD17B10TSHRCYP2A6TDP1
SCHEMBL30659037 0.71 ALDH1A1 (0.50) ALDH1A1HSD17B10TSHRCYP2A6TDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1426392-B1 COMPOSITION FOR OPTICAL MATERIAL MITSUBISHI GAS CHEMICAL CO (JP) 2010-02-24 EP disclosed
US-6960640-B2 Composition for optical material MITSUBISHI GAS CHEMICAL CO., LTD. (JP) 2005-11-01 US disclosed
US-20040147708-A1 Composition for optical material MITSUBISHI GAS CHEMICAL COMPANY, INC. (JP) 2004-07-29 US disclosed
EP-1426392-A1 COMPOSITION FOR OPTICAL MATERIAL MITSUBISHI GAS CHEMICAL COMPANY, INC. (JP) 2004-06-09 EP disclosed