Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Ether. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ether SCHEMBL4300165 | 0.95 | — | — | |
| Ether SCHEMBL351216 | 0.95 | — | — | |
| Ether SCHEMBL11292739 | 0.90 | — | — | |
| Ether SCHEMBL797466 | 0.90 | — | — | |
| Ether SCHEMBL18173787 | 0.90 | ALDH1A1 (0.41) | — | |
| Ether SCHEMBL11648502 | 0.90 | ALDH1A1 (0.41) | — | |
| Ether SCHEMBL10501726 | 0.90 | ALDH1A1 (0.41) | — | |
| Ether SCHEMBL10629462 | 0.90 | — | — | |
| Ether SCHEMBL626639 | 0.90 | ALDH1A1 (0.41) | — | |
| Ether SCHEMBL355376 | 0.90 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 314 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117209387-B | Salifying and purifying process of esmolol hydrochloride | 中国海洋大学 | 2024-04-26 | — | — | CN | claimed |
| CN-117263870-A | Preparation method of Resmetirom key intermediate III | 江西同和药业股份有限公司 | 2023-12-22 | — | — | CN | claimed |
| CN-117247525-A | Method for preparing polyester based on ring-opening polymerization of organic difunctional catalytic cyclic monomer | 南京工业大学 | 2023-12-19 | — | — | CN | claimed |
| CN-117209429-A | Photoreactive lysine and hydrochloride thereof, preparation method and application | 河北百灵威超精细材料有限公司 | 2023-12-12 | — | — | CN | claimed |
| WO-2023202464-A1 | PURIFICATION METHOD FOR ELECTRON MEDIATOR | 英科隆生物技术（杭州）有限公司 | 2023-10-26 | — | — | WO | claimed |
| CN-116731071-A | Pyrazole bridged phosphine ligand, dinuclear complex and application thereof | 上海科技大学 | 2023-09-12 | — | — | CN | claimed |
| CN-116253754-A | Method for synthesizing high-abundance boron 10 isotope biboronate | 中国科学院兰州化学物理研究所 | 2023-06-13 | — | — | CN | claimed |
| CN-111362935-B | Synthesis method of N-hydroxy tropisetron | 梯尔希（南京）药物研发有限公司 | 2022-08-19 | — | — | CN | claimed |
| CN-114751857-A | Preparation method of indacaterol impurity | 梯尔希（南京）药物研发有限公司 | 2022-07-15 | — | — | CN | claimed |
| CN-111499575-B | Method for preparing lorcaserin | 河北师范大学 | 2022-03-25 | — | — | CN | claimed |
| CN-113336713-A | Preparation method of alkoxy pyrazine derivative and alkoxy pyrazine derivative | 中国人民解放军军事科学院军事医学研究院 | 2021-09-03 | — | — | CN | claimed |
| CN-111499575-A | Method for preparing lorcaserin | 河北师范大学 | 2020-08-07 | — | — | CN | claimed |
| CN-111362935-A | Synthesis method of N-hydroxy tropisetron | 梯尔希（南京）药物研发有限公司 | 2020-07-03 | — | — | CN | claimed |
| CN-110734405-A | Synthesis method of N- (6-aminohexyl) -N '-methyl-2, 2' -biimidazole | 华东数字医学工程研究院 | 2020-01-31 | — | — | CN | claimed |
| CN-105175339-B | A kind of method for preparing dexmedetomidine hydrochloride | 辰欣药业股份有限公司 | 2018-01-16 | — | — | CN | claimed |
| CN-103992323-B | A kind of preparation method of ticagrelor | 南通常佑药业科技有限公司 | 2017-03-29 | — | — | CN | claimed |
| CN-105541649-A | Preparation method of glutamic acid-5-benzyl ester-1-tert-butyl ester hydrochloride | GL BIOCHEM (SHANGHAI) LTD | 2016-05-04 | — | — | CN | claimed |
| CN-101602734-B | Method for preparing Erlotinib hydrochloride crystal form A | ZHEJIANG JIUZHOU PHARM CO LTD | 2011-07-20 | — | — | CN | claimed |
| CN-101602734-A | A kind of preparation method of Erlotinib hydrochloride crystal form A | ZHEJIANG JIUZHOU PHARMACEUTICA (CN) | 2009-12-16 | — | — | CN | claimed |
| CN-119546656-A | Crosslinked fluorocopolymer and a fluorocopolymer composition | ＡＧＣ株式会社 | 2025-02-28 | — | — | CN | disclosed |
| CN-119451932-A | Fluorine-containing compound, fluorine-containing copolymer and fluorine-containing copolymer composition | ＡＧＣ株式会社 | 2025-02-14 | — | — | CN | disclosed |
| CN-118206569-A | Azoline ammonium quinoline carboxamide analogue, pharmaceutical composition, preparation method and medical application thereof | 上海市针灸经络研究所 | 2024-06-18 | — | — | CN | disclosed |
| CN-117209387-B | Salifying and purifying process of esmolol hydrochloride | 中国海洋大学 | 2024-04-26 | — | — | CN | disclosed |
| CN-116655674-B | Method for synthesizing high-abundance boron 10 isotope biboronate | 中国科学院兰州化学物理研究所 | 2024-04-16 | — | — | CN | disclosed |
| CN-110016055-B | Organic electroluminescent device and polycyclic compound for organic electroluminescent device | 三星显示有限公司 | 2024-02-23 | — | — | CN | disclosed |
| WO-2024009764-A1 | CROSSLINKED PRODUCT OF FLUORINE-CONTAINING COPOLYMER AND FLUORINE-CONTAINING COPOLYMER COMPOSITION | ＡＧＣ株式会社 | 2024-01-11 | — | — | WO | disclosed |
| WO-2024009763-A1 | FLUORINE-CONTAINING COMPOUND, FLUORINE-CONTAINING COPOLYMER AND FLUORINE-CONTAINING COPOLYMER COMPOSITION | ＡＧＣ株式会社 | 2024-01-11 | — | — | WO | disclosed |
| CN-117263870-A | Preparation method of Resmetirom key intermediate III | 江西同和药业股份有限公司 | 2023-12-22 | — | — | CN | disclosed |
| CN-117247525-A | Method for preparing polyester based on ring-opening polymerization of organic difunctional catalytic cyclic monomer | 南京工业大学 | 2023-12-19 | — | — | CN | disclosed |
| CN-117209429-A | Photoreactive lysine and hydrochloride thereof, preparation method and application | 河北百灵威超精细材料有限公司 | 2023-12-12 | — | — | CN | disclosed |
| CN-117209387-A | Salifying and purifying process of esmolol hydrochloride | 中国海洋大学 | 2023-12-12 | — | — | CN | disclosed |
| CN-116947783-A | Purification method of electronic mediator | 英科隆生物技术（杭州）有限公司 | 2023-10-27 | — | — | CN | disclosed |
| WO-2023202464-A1 | PURIFICATION METHOD FOR ELECTRON MEDIATOR | 英科隆生物技术（杭州）有限公司 | 2023-10-26 | — | — | WO | disclosed |
| CN-116731071-A | Pyrazole bridged phosphine ligand, dinuclear complex and application thereof | 上海科技大学 | 2023-09-12 | — | — | CN | disclosed |
| CN-116655674-A | Method for synthesizing high-abundance boron 10 isotope biboronate | 中国科学院兰州化学物理研究所 | 2023-08-29 | — | — | CN | disclosed |
| CN-113583992-B | Reductive amination enzyme and application thereof in secondary amine synthesis | 华东理工大学 | 2023-06-27 | — | — | CN | disclosed |
| CN-116253754-A | Method for synthesizing high-abundance boron 10 isotope biboronate | 中国科学院兰州化学物理研究所 | 2023-06-13 | — | — | CN | disclosed |
| CN-116003264-A | Preparation method of amine compound | 长春工业大学 | 2023-04-25 | — | — | CN | disclosed |
| CN-113336713-B | Preparation method of alkoxy pyrazine derivative and alkoxy pyrazine derivative | 中国人民解放军军事科学院军事医学研究院 | 2023-03-17 | — | — | CN | disclosed |
| CN-110662541-B | Polycyclic amines as opioid receptor modulators | 王晓冬 | 2023-02-10 | — | — | CN | disclosed |
| EP-3604306-B1 | MACROCYCLIC DERIVATIVE OF PYRAZOL[3,4-D]PYRIMIDIN-3-ONE, PHARMACEUTICAL COMPOSITION AND USE THEREOF | SHANGHAI DE NOVO PHARMATECH CO LTD (CN) | 2022-10-26 | — | — | EP | disclosed |
| CN-112608286-B | Preparation method of high-purity pramipexole | 广东红珊瑚药业有限公司 | 2022-09-30 | — | — | CN | disclosed |
| CN-112812048-B | Preparation method of sodium ion channel retarder CNV1014802 hydrochloride form | 北京蓝博特科技有限公司 | 2022-08-26 | — | — | CN | disclosed |
| CN-111362935-B | Synthesis method of N-hydroxy tropisetron | 梯尔希（南京）药物研发有限公司 | 2022-08-19 | — | — | CN | disclosed |
| CN-114751857-A | Preparation method of indacaterol impurity | 梯尔希（南京）药物研发有限公司 | 2022-07-15 | — | — | CN | disclosed |
| CN-107311846-B | Gem difluoroethyl substituted stilbene and diphenylethane derivatives, and preparation method and application thereof | 上海华理生物医药股份有限公司 | 2022-05-13 | — | — | CN | disclosed |
| CN-111499575-B | Method for preparing lorcaserin | 河北师范大学 | 2022-03-25 | — | — | CN | disclosed |
| CN-111499575-B | Method for preparing lorcaserin | 河北师范大学 | 2022-03-25 | — | — | CN | disclosed |
| EP-3453707-B1 | BENZAZEPINE DERIVATIVE, PREPARATION METHOD, PHARMACEUTICAL COMPOSITION AND USE THEREOF | SHANGHAI DE NOVO PHARMATECH CO LTD (CN) | 2022-02-16 | — | — | EP | disclosed |
| US-11251380-B2 | Organic electroluminescence device and polycyclic compound for organic electroluminescence device | SAMSUNG DISPLAY CO., LTD. (KR) | 2022-02-15 | — | — | US | disclosed |
| US-11248006-B2 | Macrocyclic derivative of pyrazol[3,4-d]pyrimidin-3-one, pharmaceutical composition and use thereof | Shanghai De Novo Pharmatech Co., Ltd. (CN) | 2022-02-15 | — | — | US | disclosed |
| CN-113583992-A | Reductive amination enzyme and application thereof in secondary amine synthesis | 华东理工大学 | 2021-11-02 | — | — | CN | disclosed |
| CN-113336713-A | Preparation method of alkoxy pyrazine derivative and alkoxy pyrazine derivative | 中国人民解放军军事科学院军事医学研究院 | 2021-09-03 | — | — | CN | disclosed |
| CN-112851930-A | Sulfur-containing polyethylene glycol resin for polypeptide synthesis | 苏州金顶生物有限公司 | 2021-05-28 | — | — | CN | disclosed |
| CN-112812048-A | Preparation method of sodium ion channel blocker CNV1014802 hydrochloride form | 北京蓝博特科技有限公司 | 2021-05-18 | — | — | CN | disclosed |
| CN-112608286-A | Preparation method of high-purity pramipexole | 广东红珊瑚药业有限公司 | 2021-04-06 | — | — | CN | disclosed |
| CN-111732650-B | Continuous flow solid phase reaction preparation of Somaloutide | 苏州金顶生物有限公司 | 2020-12-08 | — | — | CN | disclosed |
| US-20200377520-A1 | MACROCYCLIC DERIVATIVE OF PYRAZOL[3,4-D]PYRIMIDIN-3-ONE, PHARMACEUTICAL COMPOSITION AND USE THEREOF | Shanghai De Novo Pharmatech Co., Ltd. (CN) | 2020-12-03 | — | — | US | disclosed |
| WO-2020233669-A1 | INDOLE DERIVATIVE-CONTAINING INHIBITOR, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF | 上海翰森生物医药科技有限公司 (CN) | 2020-11-26 | — | — | WO | disclosed |
| CN-111732650-A | Continuous flow solid phase reaction preparation of Somaloutide | 苏州金顶生物有限公司 | 2020-10-02 | — | — | CN | disclosed |
| CN-111732734-A | Sulfur-containing polyethylene glycol modified resin | 苏州金顶生物有限公司 | 2020-10-02 | — | — | CN | disclosed |
| CN-111499575-A | Method for preparing lorcaserin | 河北师范大学 | 2020-08-07 | — | — | CN | disclosed |
| CN-111499575-A | Method for preparing lorcaserin | 河北师范大学 | 2020-08-07 | — | — | CN | disclosed |
| CN-111362935-A | Synthesis method of N-hydroxy tropisetron | 梯尔希（南京）药物研发有限公司 | 2020-07-03 | — | — | CN | disclosed |
| US-10669252-B2 | Benzazepine derivative, preparation method, pharmaceutical composition and use thereof | Shanghai De Novo Pharmatech Co., Ltd. (CN) | 2020-06-02 | — | — | US | disclosed |
| CN-108395437-B | Deuterated compound and medical application thereof | 经路纬带信息咨询(北京)有限公司 | 2020-04-14 | — | — | CN | disclosed |
| CN-106749048-B | Erlotinib hydrochloride crystal form compound and preparation method thereof | 山东裕欣药业有限公司 | 2020-03-20 | — | — | CN | disclosed |
| EP-3214088-B1 | METHOD FOR PRODUCING EUSHEARILIDES | UNIV TOKYO SCIENCE FOUND (JP) | 2020-02-26 | — | — | EP | disclosed |
| EP-3604306-A1 | MACROCYCLIC DERIVATIVE OF PYRAZOL[3,4-D]PYRIMIDIN-3-ONE, PHARMACEUTICAL COMPOSITION AND USE THEREOF | Shanghai de Novo Pharmatech Co., Ltd. (CN) | 2020-02-05 | — | — | EP | disclosed |
| CN-110734405-A | Synthesis method of N- (6-aminohexyl) -N '-methyl-2, 2' -biimidazole | 华东数字医学工程研究院 | 2020-01-31 | — | — | CN | disclosed |
| CN-106995397-B | R-amisulpride medicinal salt, preparation method, crystal form and application thereof | 河北医科大学 | 2020-01-14 | — | — | CN | disclosed |
| CN-110662541-A | Polycyclic amines as opioid receptor modulators | 王晓冬 | 2020-01-07 | — | — | CN | disclosed |
| CN-110403939-A | For treating the tricyclic nitrogenous compound of N. gonorrhoeae infections | GLAXOSMITHKLINE INTELECTUAL PROPERTY DEV LTD | 2019-11-05 | — | — | CN | disclosed |
| CN-110317153-A | A kind of N α-fluorenylmethyloxycarbonyl-N', N''- dioctyl phthalate acrylic-L-arginine preparation method | 吉尔生化（上海）有限公司 | 2019-10-11 | — | — | CN | disclosed |
| CN-106659717-B | Tricyclic nitrogen-containing compounds for the treatment of neisseria gonorrhoeae infections | 葛兰素史密斯克莱知识产权发展有限公司 | 2019-09-06 | — | — | CN | disclosed |
| CN-110088100-A | Pyrimidone derivatives as CDC7 inhibitor | 癌症研究科技有限公司 | 2019-08-02 | — | — | CN | disclosed |
| CN-107250128-B | Cyclic amine derivatives and its medical usage | 东丽株式会社 | 2019-07-26 | — | — | CN | disclosed |
| CN-110041407-A | A method of the Rayleigh synthesis acetic acid De She based on Fmoc dipeptides | 南京肽业生物科技有限公司 | 2019-07-23 | — | — | CN | disclosed |
| CN-110028496-A | A kind of synthetic method of teneligliptin related impurities | 梯尔希（南京）药物研发有限公司 | 2019-07-19 | — | — | CN | disclosed |
| CN-110016055-A | Organnic electroluminescent device and polycyclic compound for Organnic electroluminescent device | 三星显示有限公司 | 2019-07-16 | — | — | CN | disclosed |
| US-20190214585-A1 | ORGANIC ELECTROLUMINESCENCE DEVICE AND POLYCYCLIC COMPOUND FOR ORGANIC ELECTROLUMINESCENCE DEVICE | SAMSUNG DISPLAY CO., LTD. (KR) | 2019-07-11 | — | — | US | disclosed |
| EP-3508490-A1 | ORGANIC ELECTROLUMINESCENCE DEVICE AND POLYCYCLIC COMPOUND FOR ORGANIC ELECTROLUMINESCENCE DEVICE | Samsung Display Co., Ltd. (KR) | 2019-07-10 | — | — | EP | disclosed |
| US-20190152941-A1 | BENZAZEPINE DERIVATIVE, PREPARATION METHOD, PHARMACEUTICAL COMPOSITION AND USE THEREOF | Shanghai De Novo Pharmatech Co., Ltd. (CN) | 2019-05-23 | — | — | US | disclosed |
| EP-3482775-A1 | 11C-LABELLED CATECHOL DERIVATIVE, POSITRON EMISSION TOMOGRAPHY (PET) PROBE FOR PHOSPHORYLATED TAU AGGREGATION INHIBITOR USING SAME, AND PRODUCTION METHODS THEREFOR | National Center for Geriatrics and Gerontology (JP) | 2019-05-15 | — | — | EP | disclosed |
| EP-3453707-A1 | BENZAZEPINE DERIVATIVE, PREPARATION METHOD, PHARMACEUTICAL COMPOSITION AND USE THEREOF | Shanghai de Novo Pharmatech Co., Ltd. (CN) | 2019-03-13 | — | — | EP | disclosed |
| CN-106279167-B | Matrine compound derivative and preparation method and application thereof | 中国医学科学院医药生物技术研究所 | 2018-11-13 | — | — | CN | disclosed |
| CN-108395437-A | Deuterated compound and its medical usage | 泰州华元医药科技有限公司 | 2018-08-14 | — | — | CN | disclosed |
| CN-108349879-A | Synthesis of cyclohexanecarboxamide derivatives useful as sensates in consumer products | 宝洁公司 | 2018-07-31 | — | — | CN | disclosed |
| CN-105189446-B | Phloroglucin analog derivative and its purposes in treating neurodegenerative disease | 中国医学科学院药物研究所 | 2018-07-20 | — | — | CN | disclosed |
| US-20180127358-A1 | ANTI-INFLAMMATORY DRUG AND USES THEREOF | KYUSHU UNIVERSITY, NATIONAL UNIVERSITY CORPORATION (JP) | 2018-05-10 | — | — | US | disclosed |
| US-9905767-B2 | High-molecular compound and light-emitting element using same | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2018-02-27 | — | — | US | disclosed |
| CN-106957255-B | Methylisoindoline of 5 bromines of one kind (R) N Boc 1 and its preparation method and application | 上海馨远医药科技有限公司 | 2018-01-09 | — | — | CN | disclosed |
| CN-104663674-B | Fungicide compound and mixture | 杜邦公司 | 2017-11-03 | — | — | CN | disclosed |
| CN-107250129-A | Cyclic amine derivatives and its medical usage | 东丽株式会社 | 2017-10-13 | — | — | CN | disclosed |
| CN-107250128-A | Cyclic amine derivatives and its medical usage | 东丽株式会社 | 2017-10-13 | — | — | CN | disclosed |
| CN-107207462-A | Cyclic amine derivatives and its medical usage | 东丽株式会社 | 2017-09-26 | — | — | CN | disclosed |
| CN-107207489-A | It is used as the acylamino- thiadiazoles derivative of nadph oxidase inhibitor | 吉恩基奥泰克斯瑞士股份有限公司 | 2017-09-26 | — | — | CN | disclosed |
| EP-3214088-A1 | METHOD FOR PRODUCING EUSHEARILIDES | Tokyo University of Science Foundation (JP) | 2017-09-06 | — | — | EP | disclosed |
| CN-107021962-A | Fungicidal azocyclic amides | 杜邦公司 | 2017-08-08 | — | — | CN | disclosed |
| CN-106986866-A | Fungicidal azocyclic amides | 杜邦公司 | 2017-07-28 | — | — | CN | disclosed |
| CN-106957255-A | Methylisoindoline of 5 bromines of one kind (R) N Boc 1 and its preparation method and application | 上海馨远医药科技有限公司 | 2017-07-18 | — | — | CN | disclosed |
| US-9688634-B2 | Pest control agent | ISHIHARA SANGYO KAISHA, LTD. (JP) | 2017-06-27 | — | — | US | disclosed |
| CN-106659717-A | Tricyclic nitrogen-containing compounds for the treatment of neisseria gonorrhoeae infections | 葛兰素史密斯克莱知识产权发展有限公司 | 2017-05-10 | — | — | CN | disclosed |
| CN-104478805-B | Fungicidal azacyclic amides | 杜邦公司 | 2017-04-12 | — | — | CN | disclosed |
| US-9603833-B2 | Benzene or thiophene derivative and use thereof as VAP-1 inhibitor | R-TECH UENO, LTD. (JP) | 2017-03-28 | — | — | US | disclosed |
| CN-104961646-B | Mosapride active metabolites, preparation method and uses thereof | 沈阳药科大学 | 2017-02-22 | — | — | CN | disclosed |
| CN-106414388-A | Process for the manufacture of terphenyl compounds | 索尔维特殊聚合物美国有限责任公司 | 2017-02-15 | — | — | CN | disclosed |
| CN-106279167-A | Matrine compound derivative and preparation method and application thereof | 中国医学科学院医药生物技术研究所 | 2017-01-04 | — | — | CN | disclosed |
| CN-104607250-B | A kind of polyhedral oligomeric silsesquioxane dendritic macromole catalyst and application thereof | 舒兰市金马化工有限公司 | 2016-11-30 | — | — | CN | disclosed |
| CN-104105697-B | Bicyclic piperazines compound | 霍夫曼-拉罗奇有限公司 | 2016-11-09 | — | — | CN | disclosed |
| CN-105998028-A | Hydroxylamine compounds and methods of their use | 科尔比制药公司 | 2016-10-12 | — | — | CN | disclosed |
| CN-105541649-A | Preparation method of glutamic acid-5-benzyl ester-1-tert-butyl ester hydrochloride | GL BIOCHEM (SHANGHAI) LTD | 2016-05-04 | — | — | CN | disclosed |
| US-9249109-B2 | Method for preparing dipeptidyl peptidase-IV inhibitor and intermediate | DONG-A PHARMACEUTICAL CO., LTD. (KR) | 2016-02-02 | — | — | US | disclosed |
| CN-105189446-A | Phloroglucinol derivatives and application thereof in treatment of neurodegenerative disorder | INST MATERIA MEDICA CAMS | 2015-12-23 | — | — | CN | disclosed |
| US-20150336894-A1 | PEST CONTROL AGENT | ISHIHARA SANGYO KAISHA, LTD. (JP) | 2015-11-26 | — | — | US | disclosed |
| EP-2934137-A1 | PEST CONTROL AGENT | Ishihara Sangyo Kaisha, Ltd. (JP) | 2015-10-28 | — | — | EP | disclosed |
| US-20150207077-A1 | HIGH-MOLECULAR COMPOUND AND LIGHT-EMITTING ELEMENT USING SAME | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2015-07-23 | — | — | US | disclosed |
| EP-2886534-A1 | Benzene or thiophene derivative and use thereof as VAP-1 inhibitor | R-Tech Ueno, Ltd. (JP) | 2015-06-24 | — | — | EP | disclosed |
| US-20150166525-A1 | BENZENE OR THIOPHENE DERIVATIVE AND USE THEREOF AS VAP-1 INHIBITOR | R TECH UENO LTD (JP) | 2015-06-18 | — | — | US | disclosed |
| CN-104607250-A | Polyhedral oligomeric silsesquioxane dendritic macromolecule catalyst and application thereof | SHULAN JINMA CHEMICAL CO LTD | 2015-05-13 | — | — | CN | disclosed |
| CN-101888843-B | Fungicidal azacyclic amides | DU PONT | 2015-04-15 | — | — | CN | disclosed |
| CN-103517909-B | Novel anti-platelet compound addition salt | GUANGZHOU HEERSHI PHARMA DEV CO LTD | 2015-04-08 | — | — | CN | disclosed |
| US-8999989-B2 | Benzene or thiophene derivative and use thereof as VAP-1 inhibitor | R-TECH UENO, LTD. (JP) | 2015-04-07 | — | — | US | disclosed |
| US-20150025241-A1 | METHOD FOR PREPARING DIPEPTIDYL PEPTIDASE-IV INHIBITOR AND INTERMEDIATE | DONG-A PHARMACEUTICAL. CO., LTD (KR) | 2015-01-22 | — | — | US | disclosed |
| US-20140296183-A1 | AMINE COMPOUND AND USE THEREOF FOR MEDICAL PURPOSES | MITSUBISHI TANABE PHARMA CORP (JP) | 2014-10-02 | — | — | US | disclosed |
| US-8816084-B1 | Crystals of morphinan derivative, manufacturing method thereof, and pharmaceutical composition using the same | EVERLIGHT CHEMICAL INDUSTRIAL CORPORATION (TW) | 2014-08-26 | — | — | US | disclosed |
| US-8809304-B2 | Amine compound and use thereof for medical purposes | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2014-08-19 | — | — | US | disclosed |
| US-8785477-B2 | Hexahydropyrrolo[3,4-b]pyrrole derivatives, preparation methods and pharmaceutical uses thereof | SHANGHAI SUN-SAIL PHARMACEUTICAL SCIENCE & TECHNOLOGY CO., LTD. (CN) | 2014-07-22 | — | — | US | disclosed |
| EP-2578586-B1 | HEXAHYDROPYRROLO[3,4-b]PYRROLE DERIVATIVES, PREPARATION METHODS AND PHARMACEUTICAL USES THEREOF | SHANGHAI SUN SAIL PHARMACEUTICAL SCIENCE & TECHNOLOGY CO LTD (CN) | 2014-07-09 | — | — | EP | disclosed |
| WO-2014098259-A1 | PEST CONTROL AGENT | ISHIHARA SANGYO KAISHA, LTD. (JP) | 2014-06-26 | — | — | WO | disclosed |
| CN-102596867-B | Method for purification of fluorine-containing compound | SHOWA DENKO KK | 2014-06-11 | — | — | CN | disclosed |
| CN-103517909-A | Novel anti-platelet compound addition salt | GUANGZHOU HEERSHI PHARMA DEV CO LTD | 2014-01-15 | — | — | CN | disclosed |
| CN-103497148-A | Hydroxylamine compounds and methods of their use | OTHERA HOLDING INC | 2014-01-08 | — | — | CN | disclosed |
| EP-2669265-A2 | Improved method for preparing dipeptidyl peptidase-IV inhibitor and intermediate | Dong-A Pharmaceutical Co., Ltd. (KR) | 2013-12-04 | — | — | EP | disclosed |
| CN-103420924-A | Preparation method of Erlotinib Hydrochloride crystal form A | ZHEJIANG JIUZHOU PHARM CO LTD | 2013-12-04 | — | — | CN | disclosed |
| US-20130178500-A1 | HEXAHYDROPYRROLO[3,4-b]PYRROLE DERIVATIVES, PREPARATION METHODS AND PHARMACEUTICAL USES THEREOF | JIANGSU JINGLIXIN PHARMACEUTICAL TECHNOLOGY CO.,LTD. (CN) | 2013-07-11 | — | — | US | disclosed |
| CN-101687786-B | Hydroxylamine compounds and methods of use thereof | OTHERA HOLDING INC | 2013-05-22 | — | — | CN | disclosed |
| CN-103044320-A | Preparation method of 4-pyridylaldehyde | QIHE CHENGHUI FINE CHEMICAL CO LTD | 2013-04-17 | — | — | CN | disclosed |
| EP-2578586-A1 | HEXAHYDROPYRROLO[3,4-b]PYRROLE DERIVATIVES, PREPARATION METHODS AND PHARMACEUTICAL USES THEREOF | Shanghai Sun-Sail Pharmaceutical Science & Technology Co., Ltd (CN) | 2013-04-10 | — | — | EP | disclosed |
| US-20120215040-A1 | FLUORINE-CONTAINING COMPOUND PURIFICATION METHOD | SHOWA DENKO K.K. (JP) | 2012-08-23 | — | — | US | disclosed |
| CN-102596867-A | Method for purification of fluorine-containing compound | SHOWA DENKO KK | 2012-07-18 | — | — | CN | disclosed |
| CN-101454289-B | Substituted tetrahydroisoquinoline compounds, their preparation and use in medicine | ESTEVE LABOR DR | 2012-07-04 | — | — | CN | disclosed |
| EP-2415753-A2 | IMPROVED METHOD FOR PREPARING DIPEPTIDYL PEPTIDASE-IV INHIBITOR AND INTERMEDIATE | Dong-A Pharmaceutical Co., Ltd. (KR) | 2012-02-08 | — | — | EP | disclosed |
| US-20120016125-A1 | METHOD FOR PREPARING DIPEPTIDYL PEPTIDASE-IV INHIBITOR AND INTERMEDIATE | DONG-A PHARMACEUTICAL. CO., LTD (KR) | 2012-01-19 | — | — | US | disclosed |
| EP-1961734-B1 | AMINE COMPOUND AND USE THEREOF FOR MEDICAL PURPOSES | MITSUBISHI TANABE PHARMA CORP (JP) | 2011-09-14 | — | — | EP | disclosed |
| EP-1389616-B1 | 3,4-Dihalobenzylpiperidine derivatives and their medical use | MITSUBISHI TANABE PHARMA CORP (JP) | 2011-07-27 | — | — | EP | disclosed |
| CN-101602734-B | Method for preparing Erlotinib hydrochloride crystal form A | ZHEJIANG JIUZHOU PHARM CO LTD | 2011-07-20 | — | — | CN | disclosed |
| WO-2011052559-A1 | METHOD FOR PURIFICATION OF FLUORINE-CONTAINING COMPOUND | 昭和電工株式会社 (JP) | 2011-05-05 | — | — | WO | disclosed |
| EP-2300430-A1 | BENZENE OR THIOPHENE DERIVATIVE AND USE THEREOF AS VAP-1 INHIBITOR | R-Tech Ueno, Ltd. (JP) | 2011-03-30 | — | — | EP | disclosed |
| CN-101990401-A | Dual pharmacophores-PDE 4-muscarinic antagonists | GLAXO GROUP LTD | 2011-03-23 | — | — | CN | disclosed |
| US-20110059957-A1 | BENZENE OR THIOPHENE DERIVATIVE AND USE THEREOF AS VAP-1 INHIBITOR | R-TECH UENO, LTD. (JP) | 2011-03-10 | — | — | US | disclosed |
| CN-101921279-A | Spirocyclic heterocyclic derivatives and methods of their use | ADOLOR CORP | 2010-12-22 | — | — | CN | disclosed |
| CN-101888843-A | Fungicidal azacyclic amides | DU PONT | 2010-11-17 | — | — | CN | disclosed |
| CN-1668303-B | Selective estrogen receptor modulators containing phenylsulfonyl groups | LILLY CO ELI | 2010-10-27 | — | — | CN | disclosed |
| US-20100222345-A1 | NOVEL COMPOUNDS AS ANTAGONISTS OR INVERSE AGONISTS FOR OPIOID RECEPTORS | SMITHKLINE BEECHAM CORPORATION | 2010-09-02 | — | — | US | disclosed |
| CN-101602734-A | A kind of preparation method of Erlotinib hydrochloride crystal form A | ZHEJIANG JIUZHOU PHARMACEUTICA (CN) | 2009-12-16 | — | — | CN | disclosed |
| CN-101600720-A | Phosphoinositide 3-kinase inhibitor compounds and using method | HOFFMANN LA ROCHE (CH) | 2009-12-09 | — | — | CN | disclosed |
| WO-2009145360-A1 | BENZENE OR THIOPHENE DERIVATIVE AND USE THEREOF AS VAP-1 INHIBITOR | R-TECH UENO, LTD. (JP) | 2009-12-03 | — | — | WO | disclosed |
| CN-100549004-C | Spirocyclic heterocyclic derivatives and methods of use thereof | ADOLOR CORP (US) | 2009-10-14 | — | — | CN | disclosed |
| CN-101454289-A | Substituted tetrahydroisoquinoline compounds, their preparation and use in medicine | ESTEVE LABOR DR (ES) | 2009-06-10 | — | — | CN | disclosed |
| US-20090137530-A1 | Amine Compound and Use Thereof for Medical Purposes | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2009-05-28 | — | — | US | disclosed |
| CN-101443320-A | Benzothiazole derivatives as beta 2 adrenoreceptor agonists | ASTRAZENECA AB (SE) | 2009-05-27 | — | — | CN | disclosed |
| EP-2049481-A2 | NOVEL COMPOUNDS AS ANTAGONISTS OR INVERSE AGONISTS FOR OPIOID RECEPTORS | SmithKline Beecham Corporation (US) | 2009-04-22 | — | — | EP | disclosed |
| US-7432381-B2 | 3-Substituted with a trialkoxysilylalkyl- or trialkoxysilylalkoxyalkyl- group; intermediates for adhesion promoters with improved volume shrinkage characteristics, enhanced corrosion resistance and enhanced curing properties | HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) | 2008-10-07 | — | — | US | disclosed |
| EP-1961734-A1 | AMINE COMPOUND AND USE THEREOF FOR MEDICAL PURPOSES | Mitsubishi Tanabe Pharma Corporation (JP) | 2008-08-27 | — | — | EP | disclosed |
| CN-101219145-A | Quinazoline derivatives as VEGF inhibitors | ASTRAZENECA AB (SE) | 2008-07-16 | — | — | CN | disclosed |
| WO-2008021851-A2 | NOVEL COMPOUNDS AS ANTAGONISTS OR INVERSE AGONISTS FOR OPIOID RECEPTORS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-02-21 | — | — | WO | disclosed |
| EP-1019358-B2 | 3,3-DIARYLPROPYLAMINES , THEIR USE AND PREPARATION | PFIZER HEALTH AB (SE) | 2007-09-12 | — | — | EP | disclosed |
| CN-1922169-A | Spirocyclic heterocyclic derivatives and methods of use thereof | ADOLOR CORP (US) | 2007-02-28 | — | — | CN | disclosed |
| EP-1533292-B1 | DIBENZYLAMINE COMPOUND AND MEDICINAL USE THEREOF | JAPAN TOBACCO INC (JP) | 2007-02-14 | — | — | EP | disclosed |
| CN-1894243-A | 4- (pyrazol-3-ylamino) pyrimidine derivatives for the treatment of cancer | ASTRAZENECA AB (SE) | 2007-01-10 | — | — | CN | disclosed |
| US-20060293280-A1 | 1,3-Oxathiolane-2-thione compounds | HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (HENKEL KGAA) (DE) | 2006-12-28 | — | — | US | disclosed |
| CN-1871222-A | CCR3 receptor antagonists | HOFFMANN LA ROCHE (CH) | 2006-11-29 | — | — | CN | disclosed |
| US-7115635-B2 | Benzylpiperidine compound | MITSUBISHI PHARMA CORPORATION (JP) | 2006-10-03 | — | — | US | disclosed |
| US-20060154917-A1 | Substituted (heterocycloalkyl)methyl azole derivatives as c5a receptor modulators | NEUROGEN CORPORATION (US) | 2006-07-13 | — | — | US | disclosed |
| EP-1654300-A2 | SILOXANE DERIVATIVES OF 1,3-OXATHIOLANE-2-THIONES, THEIR PREPARATION AND USE THEREOF | Henkel Kommanditgesellschaft auf Aktien (DE) | 2006-05-10 | — | — | EP | disclosed |
| CN-1250519-C | Amine derivative with K channel regulation function and its preparing process and application | INST OF TOXIC MEDICAL MATERIAL (CN) | 2006-04-12 | — | — | CN | disclosed |
| CN-1250518-C | Amine derivative for preventing ischemic and anoxia damage of nerve and its medical application | INST OF TOXIC MEDICAL MATERIAL (CN) | 2006-04-12 | — | — | CN | disclosed |
| US-7022716-B2 | Cyclic amine phenyl beta-3 adrenergic receptor agonists | WYETH (US) | 2006-04-04 | — | — | US | disclosed |
| EP-1321508-B1 | Fragrance composition containing 3-(3-Hexenyl)-2-cyclopentenone | TAKASAGO PERFUMERY CO LTD (JP) | 2006-03-08 | — | — | EP | disclosed |
| CN-1229349-C | Pyridine-3-carboxylic acid derivative | PFIZER (US) | 2005-11-30 | — | — | CN | disclosed |
| CN-1668303-A | Selective estrogen receptor modulators containing phenylsulfonyl groups | LILLY CO ELI (US) | 2005-09-14 | — | — | CN | disclosed |
| CN-1205175-C | Amine derivative possessing the function of anti-pulmonary hypertension and its application in pharmacological science | INST OF TOXICANT AND MEDICAMEN (CN) | 2005-06-08 | — | — | CN | disclosed |
| US-6903067-B2 | Fragrance composition containing 3-(3-hexenyl)-2-cyclopentenone | TAKASAGO INTERNATIONAL CORPORATION (JP) | 2005-06-07 | — | — | US | disclosed |
| WO-2005016995-A1 | SILOXANE DERIVATIVES OF 1,3-OXATHIOLANE-2-THIONES, THEIR PREPARATION AND USE THEREOF | HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) | 2005-02-24 | — | — | WO | disclosed |
| WO-2005016939-A2 | SILOXANE DERIVATIVES OF 1,3-OXATHIOLANE-2-THIONES, THEIR PREPATATION AND USE THEREOF | HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) | 2005-02-24 | — | — | WO | disclosed |
| EP-1506976-A1 | Siloxane derivatives of 1,3-oxathiolane-2-thiones, their preparation and use thereof | Henkel Kommanditgesellschaft auf Aktien (DE) | 2005-02-16 | — | — | EP | disclosed |
| WO-2005009384-A2 | EGFR TYROSINE KINASE INHIBITORS | IMCLONE SYSTEMS INCORPORATED (US) | 2005-02-03 | — | — | WO | disclosed |
| WO-2005007087-A2 | SUBSTITUTED (HETEROCYCLOALKYL)METHYL AZOLE DERIVATIVES AS C5A RECEPTOR MODULATORS | NEUROGEN CORPORATION (US) | 2005-01-27 | — | — | WO | disclosed |
| CN-1181822-C | Use of 2-amino-3,4-dihydro-quinazolines for producing medicament for treating or preventing diseases caused by ischaemic conditions | ���ĵ�˹ҩ��¹�����˾ | 2004-12-29 | — | — | CN | disclosed |
| CN-1168714-C | Arylpiperazine derivatives useful as uroselective alpha-adrenoceptor blockers | ʵ | 2004-09-29 | — | — | CN | disclosed |
| US-20040158071-A1 | Chemokine inhibitors and stability in blood | MITSUBISHI PHARMA CORPORATION (JP) | 2004-08-12 | — | — | US | disclosed |
| CN-1495169-A | Pyridine-3-carboxylic acid derivative | — | 2004-05-12 | — | — | CN | disclosed |
| EP-1389616-A1 | NOVEL BENZYLPIPERIDINE COMPOUND | Mitsubishi Pharma Corporation (JP) | 2004-02-18 | — | — | EP | disclosed |
| CN-1134442-C | Pyrazolopyrimidinone cGMP PDE5 inhibitor, preparation method and application thereof and intermediate | �������۸��¼��������������ι�˾ | 2004-01-14 | — | — | CN | disclosed |
| EP-1043308-B1 | PHENYLAMINOALKYLCARBOXYLIC ACID DERIVATIVES AND MEDICINAL COMPOSITIONS CONTAINING THE SAME | KISSEI PHARMACEUTICAL (JP) | 2003-09-24 | — | — | EP | disclosed |
| US-20030158080-A1 | Fragrance composition containing 3-(3-hexenyl)-2-cyclopentenone | TAKASAGO INTERNATIONAL CORPORATION (JP) | 2003-08-21 | — | — | US | disclosed |
| US-20030144326-A1 | Cyclic amine phenyl beta-3 adrenergic receptor agonists | WYETH | 2003-07-31 | — | — | US | disclosed |
| EP-1321508-A2 | Fragrance composition containing 3-(3-Hexenyl)-2-cyclopentenone | Takasago International Corporation (JP) | 2003-06-25 | — | — | EP | disclosed |
| US-6579871-B2 | Phenyl oxazoles or thiazoles | ELI LILLY AND COMPANY | 2003-06-17 | — | — | US | disclosed |
| EP-0971709-B1 | NOVEL COMPOUNDS USEFUL AS NEURO-PROTECTIVE AGENTS | LILLY CO ELI (US) | 2003-05-21 | — | — | EP | disclosed |
| EP-1019358-B1 | 3,3-DIARYLPROPYLAMINES , THEIR USE AND PREPARATION | PHARMACIA AB (SE) | 2003-05-07 | — | — | EP | disclosed |
| CN-1415596-A | Amine derivative possessing the function of anti-pulmonary hypertension and its application in pharmacological science | INST OF TOXICANT AND MEDICAMEN (CN) | 2003-05-07 | — | — | CN | disclosed |
| EP-1301482-A1 | CYCLIC AMINE PHENYL BETA-3 ADRENERGIC RECEPTOR AGONISTS | Wyeth (US) | 2003-04-16 | — | — | EP | disclosed |
| US-20030050311-A1 | Methods of using novel compounds as neuro-protective agents | PANETTA JILL ANN (US) | 2003-03-13 | — | — | US | disclosed |
| US-6525202-B2 | E.g., substituted (4-amino-5-hydroxyphenyl)-oxy-)piperidinyl thiazolidin-2,4-dione; antidiabetic agents; atherosclerosis, gastrointestinal, metabolic disorders, glaucoma, neurogenetic inflammation, ocular hypertension and frequent urination | WYETH | 2003-02-25 | — | — | US | disclosed |
| CN-1384747-A | Use of 2-amino-3, 4-dihydroquinolines for the production of a medicament for the treatment or prevention of diseases caused by ischemic conditions | AVENTIS PHARMA GMBH (DE) | 2002-12-11 | — | — | CN | disclosed |
| US-20020177595-A1 | Novel compounds useful as neuro-protective agents | PANETTA JILL ANN (US) | 2002-11-28 | — | — | US | disclosed |
| EP-0826673-B1 | ACETAMIDE DERIVATIVES, PROCESS FOR PRODUCING THE SAME, AND MEDICINAL COMPOSITION CONTAINING THE SAME | DAINIPPON PHARMACEUTICAL CO (JP) | 2002-11-20 | — | — | EP | disclosed |
| US-6472387-B1 | Methods of using compounds as neuro-protective agents | ELI LILLY AND COMPANY | 2002-10-29 | — | — | US | disclosed |
| US-20020137736-A1 | N-(4-methoxy-3-((methylamino)methyl)phenyl)-2 -thiophenecarboximidamide, for example; nitric oxide synthase inhibitors; treating hypoxia, ischemia, stroke, Parkinson's disease, anxiety, schizophrenia, migraine and pain | ASTRAZENECA AB (SE) | 2002-09-26 | — | — | US | disclosed |
| US-20020137750-A1 | Amidine derivatives which are inhibitors of nitric oxide synthase | ASTRAZENECA AB (SE) | 2002-09-26 | — | — | US | disclosed |
| US-6448396-B2 | 2-((3,5-DIALKYL-4-HYDROXYPHENYL-4-(2-(AMINOALKYLPHENOXY)ETHYL) OXAZOLES; ANTIISCHEMIC AGENTS; REPERFUSION INJURY OF PERIPHERAL ORGANS; FREE RADICAL ANTAGONISTS; PARKINSON'S AND ALZHEIMER'S DISESES; DOWN'S SYNDROME; AMYOTROPHIC LATERAL S. | ELI LILLY AND COMPANY | 2002-09-10 | — | — | US | disclosed |
| CN-1365967-A | Amine derivative with K channel regulation function and its preparing process and application | INST OF TOXIC MEDICAL MATERIAL (CN) | 2002-08-28 | — | — | CN | disclosed |
| CN-1365966-A | Amine derivative for preventing ischemic and anoxia damage of nerve and its medical application | INST OF TOXIC MEDICAL MATERIAL (CN) | 2002-08-28 | — | — | CN | disclosed |
| US-6436922-B1 | TREATING IRRITABLE BOWEL SYNDROME | AJINOMOTO CO., INC. (JP) | 2002-08-20 | — | — | US | disclosed |
| US-6423709-B1 | FOR THERAPY OF ALZHEIMER'S DISEASE, PARKINSON'S DISEASE, AMYTROPHIC LATERAL SCLEROSIS OR CEREBRAL TRAUMA IN A MAMMAL | ELI LILLY AND COMPANY | 2002-07-23 | — | — | US | disclosed |
| US-6420377-B1 | ENZYME INHIBITOR PROMOTING CELLULAR DIFFERENTIATION, AND FOR TREATING CANCER | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL | 2002-07-16 | — | — | US | disclosed |
| US-20020065274-A1 | METHODS OF USING NOVEL COMPOUNDS AS NEURO-PROTECTIVE AGENTS | PANETTA JILL ANN (US) | 2002-05-30 | — | — | US | disclosed |
| CN-1349417-A | Contraceptive compositions containing 3,3-substituted indoline derivatives and use thereof | AMERICAN HOME PROD (US) | 2002-05-15 | — | — | CN | disclosed |
| US-6380213-B1 | PHENYL OXAZOLES, THIAZOLES, OXAZOLINES, OXADIAZOLES AND BENZOXAZOLES | ELI LILLY AND COMPANY | 2002-04-30 | — | — | US | disclosed |
| US-20020028835-A1 | Cyclic amine phenyl beta-3 adrenergic receptor agonists | WYETH | 2002-03-07 | — | — | US | disclosed |
| US-6353025-B1 | COMPOUNDS AS DRUGS | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 2002-03-05 | — | — | US | disclosed |
| EP-1180513-A1 | CYCLIC AMIDE COMPOUNDS, PROCESS FOR THE PREPARATION OF THE SAME AND USES THEREOF | Takeda Chemical Industries, Ltd. (JP) | 2002-02-20 | — | — | EP | disclosed |
| WO-2002006232-A1 | CYCLIC AMINE PHENYL BETA-3 ADRENERGIC RECEPTOR AGONISTS | WYETH (US) | 2002-01-24 | — | — | WO | disclosed |
| EP-0735031-B1 | N-acetylpiperazine derivative, antibacterial drug, and anti-ulcer drug | SHISEIDO CO LTD (JP) | 2002-01-23 | — | — | EP | disclosed |
| CN-1332740-A | 5HT antagonists for antidepressant therapy | PFIZER PROD INC (US) | 2002-01-23 | — | — | CN | disclosed |
| CN-1329589-A | N-aralkylamino 1,2,3, 4-tetrahydronaphthalenes as ligands of neuropeptide YY5 receptor | ORTHO MCNEIL PHARM INC (US) | 2002-01-02 | — | — | CN | disclosed |
| US-6313132-B1 | FOR THERAPY OF URINARY INCONTINENCE, ACETYLCHOLINE-MEDIATED DISORDER | PHARMACIA AB (SE) | 2001-11-06 | — | — | US | disclosed |
| CN-1318052-A | Arylpiperazine derivatives useful as uroselective alpha-adrenoceptor blockers | RANBAXY LAB LTD (IN) | 2001-10-17 | — | — | CN | disclosed |
| US-20010027194-A1 | NOVEL COMPOUNDS USEFUL AS NEURO-PROTECTIVE AGENTS | ELI LILLY AND COMPANY | 2001-10-04 | — | — | US | disclosed |
| EP-0889043-B1 | 5,11-DIHYDRODIBENZ b,e] 1,4]OXAZEPINE DERIVATIVES AND DRUG COMPOSITIONS CONTAING THE DERIVATIVES | AJINOMOTO KK (JP) | 2001-08-29 | — | — | EP | disclosed |
| CN-1305478-A | Pyrazolopyrimidinone cGMP PDE5 inhibitors for the treatment of sexual dysfunction | PFIZER (US) | 2001-07-25 | — | — | CN | disclosed |
| CN-1302297-A | Pyrimidin-aminomethyl-pyridine derivatives, their preparation and their use in control of helicobacter bacteria | BYK GULDEN LOMBERG CHEM FAB (DE) | 2001-07-04 | — | — | CN | disclosed |
| WO-2001046170-A1 | AMIDINE DERIVATIVES WHICH ARE INHIBITORS OF NITRIC OXIDE SYNTHASE | ASTRAZENECA AB (SE) | 2001-06-28 | — | — | WO | disclosed |
| WO-2001046171-A1 | AMIDINE DERIVATIVES WHICH ARE INHIBITORS OF NITRIC OXIDE SYNTHASE | ASTRAZENECA AB (SE) | 2001-06-28 | — | — | WO | disclosed |
| EP-0971709-A4 | NOVEL COMPOUNDS USEFUL AS NEURO-PROTECTIVE AGENTS | LILLY CO ELI (US) | 2001-04-11 | — | — | EP | disclosed |
| US-6207673-B1 | FOR CANCER THERAPY | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL | 2001-03-27 | — | — | US | disclosed |
| CN-1284057-A | Adamantane derivatives | ASTRA ZENECA BRITISH LTD (GB) | 2001-02-14 | — | — | CN | disclosed |
| US-6166216-A | Compounds useful as neuro-protective agents | ELI LILLY AND COMPANY (US) | 2000-12-26 | — | — | US | disclosed |
| US-6156748-A | Compounds useful as neuro-protective agents | ELI LILLY AND COMPANY (US) | 2000-12-05 | — | — | US | disclosed |
| EP-1043308-A1 | PHENYLAMINOALKYLCARBOXYLIC ACID DERIVATIVES AND MEDICINAL COMPOSITIONS CONTAINING THE SAME | Kissei Pharmaceutical Co., Ltd. (JP) | 2000-10-11 | — | — | EP | disclosed |
| US-6127361-A | FOR TREATMENT OR PREVENTION OF GASTROINTESTINAL MOVING FUNCTION DISORDERS, IRRITABLE BOWEL SYNDROME | AJINOMO CO., INC. (JP) | 2000-10-03 | — | — | US | disclosed |
| EP-1019358-A1 | NOVEL COMPOUNDS, THEIR USE AND PREPARATION | Pharmacia & Upjohn AB (SE) | 2000-07-19 | — | — | EP | disclosed |
| CN-1052723-C | Bicyclic aromatic compounds as therapeutic agents | KNOLL AG (DE) | 2000-05-24 | — | — | CN | disclosed |
| EP-0988058-A2 | COVALENT CONJUGATES OF TOPOISOMERASE I AND TOPOISOMERASE II INHIBITORS | Yale University (US) | 2000-03-29 | — | — | EP | disclosed |
| EP-0971709-A1 | NOVEL COMPOUNDS USEFUL AS NEURO-PROTECTIVE AGENTS | ELI LILLY AND COMPANY (US) | 2000-01-19 | — | — | EP | disclosed |
| CN-1239889-A | Novel compounds useful as neuroprotective agents | LILLY CO ELI (US) | 1999-12-29 | — | — | CN | disclosed |
| CN-1237963-A | Quinoline derivatives inhibiting the action of growth factors such as VEGF | ZENECA LTD (GB) | 1999-12-08 | — | — | CN | disclosed |
| US-5972946-A | NERVOUS SYSTEM DISORDERS; PSYCHOLOGICAL DISORDERS | DAINIPPON PHARMACEUTICAL CO., LTD. (JP) | 1999-10-26 | — | — | US | disclosed |
| US-5952360-A | Method for treating neuropathic pain | ELI LILLY AND COMPANY (US) | 1999-09-14 | — | — | US | disclosed |
| US-5942530-A | Method for treating pain | ELI LILLY AND COMPANY (US) | 1999-08-24 | — | — | US | disclosed |
| WO-1999018091-A1 | NOVEL COMPOUNDS USEFUL AS NEURO-PROTECTIVE AGENTS | ELI LILLY AND COMPANY (US) | 1999-04-15 | — | — | WO | disclosed |
| EP-0908186-A2 | Method for treating pain | ELI LILLY AND COMPANY (US) | 1999-04-14 | — | — | EP | disclosed |
| EP-0908454-A2 | Oxazoles, thiazoles, oxazolines, oxadiazoles and benzoxazoles useful as neuro-protective agents | ELI LILLY AND COMPANY (US) | 1999-04-14 | — | — | EP | disclosed |
| EP-0908180-A2 | Use of phenyl oxazole or phenyl thiazole derivatives for treating pain | ELI LILLY AND COMPANY (US) | 1999-04-14 | — | — | EP | disclosed |
| EP-0906755-A2 | Use of phenyl oxazole or phenyl thiazole derivatives for treating neuropathic pain | ELI LILLY AND COMPANY (US) | 1999-04-07 | — | — | EP | disclosed |
| WO-1999009979-A1 | METHOD FOR TREATING NEUROPATHIC PAIN | ELI LILLY AND COMPANY (US) | 1999-03-04 | — | — | WO | disclosed |
| WO-1999009829-A1 | METHOD FOR TREATING PAIN | ELI LILLY AND COMPANY (US) | 1999-03-04 | — | — | WO | disclosed |
| WO-1999009980-A1 | METHOD FOR TREATING PAIN | ELI LILLY AND COMPANY (US) | 1999-03-04 | — | — | WO | disclosed |
| EP-0889043-A1 | 5,11-DIHYDRODIBENZ b,e] 1,4]OXAZEPINE DERIVATIVES AND DRUG COMPOSITIONS CONTAING THE DERIVATIVES | Ajinomoto Co., Inc. (JP) | 1999-01-07 | — | — | EP | disclosed |
| WO-1998043942-A1 | NOVEL COMPOUNDS, THEIR USE AND PREPARATION | PHARMACIA & UPJOHN AB (SE) | 1998-10-08 | — | — | WO | disclosed |
| WO-1998040104-A2 | COVALENT CONJUGATES OF TOPOISOMERASE I AND TOPOISOMERASE II INHIBITORS | YALE UNIVERSITY (US) | 1998-09-17 | — | — | WO | disclosed |
| US-5756505-A | N-acylpiperazine derivative, antibacterial drug and anti-ulcer drug | SHISEIDO CO., LTD. (JP) | 1998-05-26 | — | — | US | disclosed |
| WO-1998015274-A1 | NOVEL COMPOUNDS USEFUL AS NEURO-PROTECTIVE AGENTS | ELI LILLY AND COMPANY (US) | 1998-04-16 | — | — | WO | disclosed |
| EP-0826673-A1 | ACETAMIDE DERIVATIVES, PROCESS FOR PRODUCING THE SAME, AND MEDICINAL COMPOSITION CONTAINING THE SAME | DAINIPPON PHARMACEUTICAL CO., LTD. (JP) | 1998-03-04 | — | — | EP | disclosed |
| CN-1142817-A | 1N-alkyl-N-arylpyrimidinamines and derivatives thereof | DU PONT MERCK PHARMA (US) | 1997-02-12 | — | — | CN | disclosed |
| CN-1133043-A | Bicyclic aromatic compounds as therapeutic agents | BOOTS CO PLC (DE) | 1996-10-09 | — | — | CN | disclosed |
| EP-0735031-A1 | N-acetylpiperazine derivative, antibacterial drug, and anti-ulcer drug | SHISEIDO COMPANY LIMITED (JP) | 1996-10-02 | — | — | EP | disclosed |
| EP-0495982-B1 | BICYCLIC PYRIMIDINE DERIVATIVE, METHOD OF PRODUCING THE SAME, AND PHARMACEUTICAL PREPARATION CONTAINING THE SAME AS ACTIVE INGREDIENT | TEIJIN LTD (JP) | 1996-06-12 | — | — | EP | disclosed |
| US-5378700-A | Against hypoxemia of respiratory diseases | TEIJIN LIMITED (JP) | 1995-01-03 | — | — | US | disclosed |
| CN-1025031-C | 2-oxo-3,8-diaza-spiro [4,5] decane derivatives, pharmaceutical compositions containing such derivatives and process for preparing them | RICHTER GEDEON VEGYESZET (HU) | 1994-06-15 | — | — | CN | disclosed |
| CN-1024667-C | process for preparing substituted aminomethyl tetralins and substituted aminomethyl hydrogenated benzopyrans and their salts | BAYER AG (DE) | 1994-05-25 | — | — | CN | disclosed |
| EP-0547705-A1 | Pharmacologically active tricyclic benzotriazepine derivatives | CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS (ES) | 1993-06-23 | — | — | EP | disclosed |
| EP-0495982-A1 | BICYCLIC PYRIMIDINE DERIVATIVE, METHOD OF PRODUCING THE SAME, AND PHARMACEUTICAL PREPARATION CONTAINING THE SAME AS ACTIVE INGREDIENT | TEIJIN LIMITED (JP) | 1992-07-29 | — | — | EP | disclosed |
| US-5068238-A | Anticonvulsants, schizophrenia, sleep disorders, antiischemia agents and cognition activators | RHONE-POULENC SANTE (FR) | 1991-11-26 | — | — | US | disclosed |
| EP-0114273-B1 | NEW PHARMACOLOGICALLY ACTIVE PYRAZOLOPYRIDINES | GRUPPO LEPETIT S.p.A. (IT) | 1991-11-06 | — | — | EP | disclosed |
| US-5047432-A | Antidepressants | THE BOOTS COMPANY PLC (GB) | 1991-09-10 | — | — | US | disclosed |
| CN-1049349-A | New 2-oxo-3,8-diaza spiro [4,5] decane derivative contains formula of medicine of these derivatives and preparation method thereof | RICHTER GEDEON VEGYESZET (HU) | 1991-02-20 | — | — | CN | disclosed |
| EP-0391414-A2 | Benzazepine and benzothiazepine derivatives | E.R. SQUIBB & SONS, INC. (US) | 1990-10-10 | — | — | EP | disclosed |
| US-4954508-A | HYPOTENSIVE | GRUPPO LEPETIT S.P.A. (IT) | 1990-09-04 | — | — | US | disclosed |
| US-4946840-A | Benzazepine and benzothiazepine derivatives | E. R. SQUIBB & SONS, INC. (US) | 1990-08-07 | — | — | US | disclosed |
| EP-0127167-B1 | 3-(4-PIPERIDINYL)-1,2-BENZISOTHIAZOLES AND DERIVATIVES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICAMENTS | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1990-04-04 | — | — | EP | disclosed |
| CN-1039809-A | The aminomethyl tetraline that replaces and the preparation of heterocycle homologue thereof | BAYER AG (DE) | 1990-02-21 | — | — | CN | disclosed |
| US-4902684-A | Benzazepine and benzothiazepine derivatives | E. R. SQUIBB & SONS, INC. (US) | 1990-02-20 | — | — | US | disclosed |
| WO-1989012633-A1 | BENZAZEPINE AND BENZOTHIAZEPINE DERIVATIVES | E.R. SQUIBB & SONS, INC. (US) | 1989-12-28 | — | — | WO | disclosed |
| US-4723008-A | VIRICIDES | NISSHIN FLOUR MILLING CO., LTD. (JP) | 1988-02-02 | — | — | US | disclosed |
| EP-0097202-B1 | HYDRAZINOPYRIDAZINE COMPOUND, PROCESS FOR PRODUCTION THEREOF, AND USE THEREOF AS MEDICAMENT | TEIKOKU HORMONE MFG. CO., LTD. (JP) | 1987-11-19 | — | — | EP | disclosed |
| US-4700002-A | VIRICIDES; INTERFERON INDUCERS | NISSHIN FLOUR MILLING CO., LTD. (JP) | 1987-10-13 | — | — | US | disclosed |
| EP-0067105-B1 | ALLYL AMINE MAO INHIBITORS | MERRELL DOW FRANCE ET CIE (FR) | 1987-09-23 | — | — | EP | disclosed |
| US-4658063-A | Isoprenylamine derivatives | NISSHIN FLOUR MILLING CO., LTD. (JP) | 1987-04-14 | — | — | US | disclosed |
| US-4645862-A | VIRICIDES; INTERFERON-INDUCING ABILITY | NISSHIN FLOUR MILLING CO., LTD. (JP) | 1987-02-24 | — | — | US | disclosed |
| EP-0205334-A2 | Benzazepine derivatives | E.R. Squibb & Sons, Inc. (US) | 1986-12-17 | — | — | EP | disclosed |
| CN-86100131-A | The preparation and the application thereof of octahydro indolizine compound | — | 1986-10-15 | — | — | CN | disclosed |
| US-4599333-A | HYPOTENSIVE AGENTS | TEIKOKU HORMONE MFG. CO., LTD. (JP) | 1986-07-08 | — | — | US | disclosed |
| US-4558056-A | PSYCHOLOGICAL DISORDERS | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1985-12-10 | — | — | US | disclosed |
| US-4524074-A | TREATMENT OF PSYCHOSES | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1985-06-18 | — | — | US | disclosed |
| US-4495101-A | Antiinflammatory 5H-tetrazolo (5,1-c)(1,4)benzodiazepine derivatives | AMERICAN HOME PRODUCTS CORPORATION (US) | 1985-01-22 | — | — | US | disclosed |
| EP-0127167-A2 | 3-(4-Piperidinyl)-1,2-benzisothiazoles and derivatives, a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1984-12-05 | — | — | EP | disclosed |
| EP-0114273-A1 | New pharmacologically active pyrazolopyridines | GRUPPO LEPETIT S.p.A. (IT) | 1984-08-01 | — | — | EP | disclosed |
| US-4458076-A | ANALGESICS, ANTIPSYCHOTICS | HOECHST-ROUSSEL PHARMACEUTICALS (US) | 1984-07-03 | — | — | US | disclosed |
| US-4454158-A | Allyl amine MAO inhibitors | MERRELL TORAUDE ET COMPAGNIE (FR) | 1984-06-12 | — | — | US | disclosed |
| EP-0097202-A1 | Hydrazinopyridazine compound, process for production thereof, and use thereof as medicament | TEIKOKU HORMONE MFG. CO., LTD. (JP) | 1984-01-04 | — | — | EP | disclosed |
| US-4386084-A | BACTERICIDES; SULFONAMIDE POTENTIATION | BASF AKTIENGESELLSCHAFT (DE) | 1983-05-31 | — | — | US | disclosed |
| EP-0009655-B1 | 6-AMINO SUBSTITUTED N-PYRROLYL-3-PYRIDAZINE AMINES, THEIR PREPARATION, AND PHARMACEUTICALLY ANTIHYPERTENSIVE COMPOSITIONS CONTAINING THEM | GRUPPO LEPETIT S.P.A. (IT) | 1983-05-11 | — | — | EP | disclosed |
| EP-0023385-B1 | ETHANAMINE DERIVATIVES, THEIR PREPARATION AND USE IN PHARMACEUTICAL COMPOSITIONS | BEECHAM GROUP PLC (GB) | 1982-12-15 | — | — | EP | disclosed |
| EP-0067105-A2 | Allyl amine MAO inhibitors | MERRELL DOW FRANCE ET CIE (FR) | 1982-12-15 | — | — | EP | disclosed |
| US-4338333-A | ANTIOBESITY, HYPOGLYCEMIC | BEECHAM GROUP LIMITED (GB) | 1982-07-06 | — | — | US | disclosed |
| US-4318925-A | 4-Homoisotwistane derivatives | SUMITOMO CHEMICAL CO., LTD. (JP) | 1982-03-09 | — | — | US | disclosed |
| EP-0023385-A1 | Ethanamine derivatives, their preparation and use in pharmaceutical compositions | BEECHAM GROUP PLC (GB) | 1981-02-04 | — | — | EP | disclosed |
| US-4247551-A | N-Pyrrolyl-pyridazineamines and their use as antihypertensive agents | GRUPPO LEPETIT S.P.A. (IT) | 1981-01-27 | — | — | US | disclosed |
| EP-0009655-A1 | 6-Amino substituted N-pyrrolyl-3-pyridazine amines, their preparation, and pharmaceutically antihypertensive compositions containing them | GRUPPO LEPETIT S.P.A. (IT) | 1980-04-16 | — | — | EP | disclosed |
| US-4166062-A | HYPOTENSIVE AGENTS, CNS, ANTIDEPRESSANTS | THE UPJOHN COMPANY (US) | 1979-08-28 | — | — | US | disclosed |
| US-4018922-A | NEUROLEPTICS, ANALGESICS, SPASMOLYTICS, AND ANTIHISTAMINES | ROUSSEL-UCLAF (FR) | 1977-04-19 | — | — | US | disclosed |
| US-4018922-A | NEUROLEPTICS, ANALGESICS, SPASMOLYTICS, AND ANTIHISTAMINES | ROUSSEL-UCLAF (FR) | 1977-04-19 | — | — | US | disclosed |