Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 9/20 | 0.43 |
| ▸ | HTT | P42858 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2690381 | 0.88 | MAPT (0.44) | PKMMAPTHTTSMN1; SMN2NPC1 | |
| SCHEMBL13388974 | 0.81 | PKM (0.42) | PKMMAPTHTTSMN1; SMN2ALDH1A1 | |
| SCHEMBL3667953 | 0.77 | PKM (0.44) | PKMMAPTHTTSMN1; SMN2NPC1 | |
| SCHEMBL9202861 | 0.77 | PKM (0.44) | PKMMAPTHTTSMN1; SMN2NPC1 | |
| SCHEMBL29242779 | 0.77 | PKM (0.42) | PKMMAPTHTTALDH1A1TDP1 | |
| SCHEMBL3876185 | 0.75 | PKM (0.41) | PKMMAPTHTTNPC1RAB9A | |
| SCHEMBL27391845 | 0.75 | PKM (0.41) | PKMMAPTHTTALDH1A1TDP1 | |
| SCHEMBL11834710 | 0.73 | PKM (0.44) | PKMMAPTHTTSMN1; SMN2NPC1 | |
| SCHEMBL8358007 | 0.73 | PKM (0.39) | PKMMAPTHTTNPC1RAB9A | |
| SCHEMBL9465187 | 0.72 | PKM (0.44) | PKMMAPTHTTSMN1; SMN2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105753779-B | 2- pyridyl amine compounds and preparation method and application | 湖南化工研究院有限公司 | 2018-06-26 | — | — | CN | claimed |
| CN-105753779-A | 2-pyridylamine compounds, preparing method thereof and applications of the compounds | 湖南化工研究院有限公司 | 2016-07-13 | — | — | CN | claimed |
| CN-105753779-B | 2- pyridyl amine compounds and preparation method and application | 湖南化工研究院有限公司 | 2018-06-26 | — | — | CN | disclosed |
| CN-105753779-A | 2-pyridylamine compounds, preparing method thereof and applications of the compounds | 湖南化工研究院有限公司 | 2016-07-13 | — | — | CN | disclosed |
| EP-2240485-A1 | TRICYCLIC COMPOUNDS HAVING CORTICOTROPIN-RELEASING FACTOR ANTAGONISTIC ACTIVITY AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Takeda Pharmaceutical Company Limited (JP) | 2010-10-20 | — | — | EP | disclosed |
| WO-2009093747-A1 | TRICYCLIC COMPOUNDS HAVING CORTICOTROPIN-RELEASING FACTOR ANTAGONISTIC ACTIVITY AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-07-30 | — | — | WO | disclosed |