Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.44 |
| ▸ | HTT | P42858 | 4/20 | 0.44 |
| ▸ | PKM | P14618 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 4/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3674616 | 0.88 | PKM (0.46) | MAPTHTTPKMALDH1A1LMNA | |
| SCHEMBL9202861 | 0.82 | PKM (0.44) | MAPTHTTPKMALDH1A1LMNA | |
| SCHEMBL3667953 | 0.78 | PKM (0.44) | MAPTHTTPKMALDH1A1TP53 | |
| SCHEMBL28306158 | 0.77 | PKM (0.41) | MAPTHTTPKMALDH1A1TP53 | |
| SCHEMBL3876185 | 0.76 | PKM (0.41) | MAPTHTTPKMALDH1A1TP53 | |
| SCHEMBL11834710 | 0.74 | PKM (0.44) | MAPTHTTPKMALDH1A1TP53 | |
| SCHEMBL8358007 | 0.74 | PKM (0.39) | MAPTHTTPKMALDH1A1TP53 | |
| SCHEMBL9465187 | 0.73 | PKM (0.44) | MAPTHTTPKMALDH1A1LMNA | |
| SCHEMBL29242779 | 0.73 | PKM (0.42) | MAPTHTTPKMALDH1A1TP53 | |
| SCHEMBL1625081 | 0.73 | LMNA (0.55) | MAPTHTTPKMALDH1A1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8815895-B2 | Mediators of hedgehog signaling pathways, compositions and uses related hereto | CURIS, INC. (US) | 2014-08-26 | — | — | US | disclosed |
| EP-1807074-B1 | MEDIATORS OF HEDGEHOG SIGNALING PATHWAYS, COMPOSITIONS AND USES RELATED THERETO | CURIS INC (US) | 2013-10-23 | — | — | EP | disclosed |
| US-20130217664-A1 | NOVEL COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE AND INFLAMMATORY DISEASES | GALAPAGOS NV (BE) | 2013-08-22 | — | — | US | disclosed |
| WO-2013117645-A1 | IMIDAZO [4, 5 -C] PYRIDINE DERIVATIVES USEFUL FOR THE TREATMENT OF DEGENERATIVE AND INFLAMMATORY DISEASES | GALAPAGOS NV (BE) | 2013-08-15 | — | — | WO | disclosed |
| US-20120283258-A1 | MEDIATORS OF HEDGEHOG SIGNALING PATHWAYS, COMPOSITIONS AND USES RELATED HERETO | CURIS, INC. (US) | 2012-11-08 | — | — | US | disclosed |
| US-8168653-B2 | Mediators of hedgehog signaling pathways, compositions and uses related thereto | CURIS, INC. (US) | 2012-05-01 | — | — | US | disclosed |
| US-20100317660-A1 | Mediators of hedgehog signaling pathways, compositions and uses related thereto | GUICHERIT OIVIN M | 2010-12-16 | — | — | US | disclosed |
| US-7816369-B2 | hedgehog genes antagonists such as N-[5-(1H-benzimidazol-2-yl)-6-chloropyridin-3-yl]-2-methyl-6-(trifluoromethyl)pyridine-3-carboxamide, used as anticarcinogenic or antitumor agents | CURIS, INC. (US) | 2010-10-19 | — | — | US | disclosed |
| US-20090012082-A1 | hedgehog genes antagonists such as N-[5-(1H-benzimidazol-2-yl)-6-chloropyridin-3-yl]-2-methyl-6-(trifluoromethyl)pyridine-3-carboxamide, used as anticarcinogenic or antitumor agents | CURIS, INC. (US) | 2009-01-08 | — | — | US | disclosed |
| EP-1807074-A1 | MEDIATORS OF HEDGEHOG SIGNALING PATHWAYS, COMPOSITIONS AND USES RELATED THERETO | Curis, Inc. (US) | 2007-07-18 | — | — | EP | disclosed |
| WO-2006050506-A1 | MEDIATORS OF HEDGEHOG SIGNALING PATHWAYS, COMPOSITIONS AND USES RELATED THERETO | CURIS, INC. (US) | 2006-05-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100317660-A1 | Mediators of hedgehog signaling pathways, compositions and uses related thereto | SHH, SMO, GLI1 | MAPT 4763/4885HTT 3532/4885PKM 4560/4885 |
| US-20130217664-A1 | NOVEL COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE AND INFLAMMATORY DISEASES | JAK1, IL6, JAK3 | MAPT 4801/4885HTT 1693/4885PKM 848/4885 |
| US-20090012082-A1 | hedgehog genes antagonists such as N-[5-(1H-benzimidazol-2-yl)-6-chloropyridin-3-yl]-2-methyl-6-(trifluoromethyl)pyridine-3-carboxamide, used as anticarcinogenic or antitumor agents | GLI1, SHH, SMO | MAPT 4799/4885HTT 2597/4885PKM 4707/4885 |
| US-20120283258-A1 | MEDIATORS OF HEDGEHOG SIGNALING PATHWAYS, COMPOSITIONS AND USES RELATED HERETO | SHH, SMO, GLI1 | MAPT 4728/4885HTT 3163/4885PKM 4566/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.