Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 8/20 | 0.46 |
| ▸ | RAB9A | P51151 | 8/20 | 0.46 |
| ▸ | TP53 | P04637 | 4/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.45 |
| ▸ | POLB | P06746 | 3/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | KCNA3 | P22001 | 3/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | CDK1 | P06493 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4551862 | 0.84 | ROCK2 (0.38) | NPC1RAB9AGAAGSK3B | |
| SCHEMBL3674767 | 0.83 | MAPK1 (0.48) | NPC1RAB9ATP53SMN1; SMN2POLB | |
| SCHEMBL4551736 | 0.78 | ALDH1A1 (0.37) | NPC1RAB9AALDH1A1GAAKMT2A | |
| SCHEMBL30211623 | 0.66 | POLB (0.61) | SMN1; SMN2POLBTHRBRECQLTDP1 | |
| SCHEMBL22505247 | 0.66 | POLB (0.61) | SMN1; SMN2POLBTHRBRECQLTDP1 | |
| SCHEMBL11994154 | 0.64 | CHRNB2 (0.64) | SMN1; SMN2ALDH1A1LMNAGAAHTT | |
| SCHEMBL17117168 | 0.62 | NPC1 (1.00) | NPC1RAB9ATP53SMN1; SMN2POLB | |
| SCHEMBL26409544 | 0.62 | POLB (0.56) | SMN1; SMN2POLBTHRBRECQLTDP1 | |
| SCHEMBL9592081 | 0.61 | POLB (0.55) | NPC1RAB9ASMN1; SMN2POLBTHRB | |
| SCHEMBL12349834 | 0.61 | TP53 (0.78) | NPC1RAB9ATP53SMN1; SMN2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2162136-A1 | BENZAMIDE MGLUR5 POSITIVE ALLOSTERIC MODULATORS AND METHODS OF MAKING AND USING SAME | VANDERBILT UNIVERSITY (US) | 2010-03-17 | — | — | EP | disclosed |
| WO-2008151184-A1 | BENZAMIDE MGLUR5 POSITIVE ALLOSTERIC MODULATORS AND METHODS OF MAKING AND USING SAME | VANDERBILT UNIVERSITY (US) | 2008-12-11 | — | — | WO | disclosed |