Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4442945 | 0.71 | ALDH1A1 (0.46) | ALDH1A1 | |
| SCHEMBL11292029 | 0.67 | — | — | |
| SCHEMBL5697611 | 0.64 | — | — | |
| SCHEMBL7529177 | 0.64 | — | — | |
| SCHEMBL124779 | 0.64 | — | — | |
| SCHEMBL2050724 | 0.64 | — | — | |
| SCHEMBL216856 | 0.64 | ALDH1A1 (0.39) | ALDH1A1 | |
| SCHEMBL2719867 | 0.61 | — | — | |
| SCHEMBL180902 | 0.61 | — | — | |
| SCHEMBL17481183 | 0.61 | ALDH1A1 (0.46) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3356329-B1 | PROCESS FOR PREPARING 1-(4-METHANESULFONYL-2-TRIFLUOROMETHYL-BENZYL)-2-METHYL-1H-PYRROLO [2,3-B]PYRIDIN-3-YL-ACETIC ACID | NOVARTIS AG (CH) | 2020-04-15 | — | — | EP | disclosed |
| US-10508110-B2 | Process for preparing 1-(4-methanesulfonyl-2-trifluoromethyl-benzyl)-2-methyl-1H-pyrrolo [2,3-B]pyridin-3-yl-acetic acid | NOVARTIS AG (CH) | 2019-12-17 | — | — | US | disclosed |
| US-20180273530-A1 | PROCESS FOR PREPARING 1-(4-METHANESULFONYL-2-TRIFLUOROMETHYL-BENZYL)-2-METHYL-1H-PYRROLO [2,3-B]PYRIDIN-3-YL-ACETIC ACID | NOVARTIS PHARMA AG (CH) | 2018-09-27 | — | — | US | disclosed |
| EP-2922841-B1 | ALKYL-AMIDE-SUBSTITUTED PYRIDYL COMPOUNDS USEFUL AS MODULATORS OF IL-12, IL-23 AND/OR IFN ALPHA RESPONSES | BRISTOL MYERS SQUIBB CO (US) | 2017-06-07 | — | — | EP | disclosed |
| US-9315494-B2 | Alkyl-amide-substituted pyridyl compounds useful as modulators of IL-12, IL-23 and/or IFNα responses | BRISTOL-MYERS SQUIBB COMPANY (US) | 2016-04-19 | — | — | US | disclosed |
| US-20150307483-A1 | ALKYL-AMIDE-SUBSTITUTED PYRIDYL COMPOUNDS USEFUL AS MODULATORS OF IL-12, IL-23 AND/OR IFN ALPHA RESPONSES | BRISTOL-MYERS SQUIBB COMPANY | 2015-10-29 | — | — | US | disclosed |
| EP-2922841-A1 | ALKYL-AMIDE-SUBSTITUTED PYRIDYL COMPOUNDS USEFUL AS MODULATORS OF IL-12, IL-23 AND/OR IFN ALPHA RESPONSES | Bristol-Myers Squibb Company (US) | 2015-09-30 | — | — | EP | disclosed |
| EP-2673267-B1 | 1,3-DIOXAN-5-ONE COMPOUNDS | MERCK PATENT GMBH (DE) | 2015-06-03 | — | — | EP | disclosed |
| WO-2014074660-A1 | ALKYL-AMIDE-SUBSTITUTED PYRIDYL COMPOUNDS USEFUL AS MODULATORS OF IL-12, IL-23 AND/OR IFNα RESPONSES | BRISTOL-MYERS SQUIBB COMPANY (US) | 2014-05-15 | — | — | WO | disclosed |
| EP-2673267-A1 | 1,3-DIOXAN-5-ONE COMPOUNDS | Merck Patent GmbH (DE) | 2013-12-18 | — | — | EP | disclosed |
| US-20130309184-A1 | 1,3-DIOXAN-5-ONE COMPOUNDS | MERCK PATENT GMBH (DE) | 2013-11-21 | — | — | US | disclosed |
| WO-2012107158-A1 | 1,3-DIOXAN-5-ONE COMPOUNDS | MERCK PATENT GMBH (DE) | 2012-08-16 | — | — | WO | disclosed |
| EP-2108646-B1 | Alpha, Alpha'-Dihydroxyketone derivatives and their use as UV filters | MERCK PATENT GMBH (DE) | 2010-10-27 | — | — | EP | disclosed |
| EP-2108646-A1 | Alpha, Alpha'-Dihydroxyketone derivatives and their use as UV filters | Merck Patent GmbH (DE) | 2009-10-14 | — | — | EP | disclosed |
| EP-1934188-A2 | ALPHA, ALPHA`-DIHYDROXY KETONE DERIVATIVES AND USE THEREOF AS UV FILTER | Merck Patent GmbH (DE) | 2008-06-25 | — | — | EP | disclosed |
| WO-2007039110-A2 | α, α′-DIHYDROXY KETONE DERIVATIVES AND USE THEREOF AS UV FILTER | MERCK PATENT GMBH (DE) | 2007-04-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150307483-A1 | ALKYL-AMIDE-SUBSTITUTED PYRIDYL COMPOUNDS USEFUL AS MODULATORS OF IL-12, IL-23 AND/OR IFN ALPHA RESPONSES | IFNG, TYK2, IFNAR1 | ALDH1A1 4551/4885 |
| US-20180273530-A1 | PROCESS FOR PREPARING 1-(4-METHANESULFONYL-2-TRIFLUOROMETHYL-BENZYL)-2-METHYL-1H-PYRROLO [2,3-B]PYRIDIN-3-YL-ACETIC ACID | MMAB, PAH, CPS1 | ALDH1A1 340/4885 |
| US-10508110-B2 | Process for preparing 1-(4-methanesulfonyl-2-trifluoromethyl-benzyl)-2-methyl-1H-pyrrolo [2,3-B]pyridin-3-yl-acetic acid | MMAB, PAH, CPS1 | ALDH1A1 340/4885 |
| US-20130309184-A1 | 1,3-DIOXAN-5-ONE COMPOUNDS | AOX1, OCIAD1, OCIAD2 | ALDH1A1 43/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.