SCHEMBL367665

SCHEMBL367665

Clc1ccc(C(Cl)(c2ccccc2)c2ccccc2)cc1

nearest known ligand 0.61

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
CYP19A1 P11511 6/20 0.61
TSHR P16473 3/20 0.50
KIF11 P52732 3/20 0.48
MAPK1 P28482 1/20 0.48
HIF1A Q16665 1/20 0.48
CYP1A2 P05177 2/20 0.48
MEN1 O00255 1/20 0.42
KMT2A Q03164 1/20 0.42
LMNA P02545 1/20 0.42
CYP2A6 P11509 1/20 0.42
BCL2 P10415 1/20 0.42
MIF P14174 1/20 0.40
L3MBTL1 Q9Y468 1/20 0.40
CES2 O00748 1/20 0.39
CES1 P23141 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11652133 1.00 CYP19A1 (0.61) CYP19A1TSHRKIF11MAPK1HIF1A
SCHEMBL1224870 1.00 CYP19A1 (0.61) CYP19A1TSHRKIF11MAPK1HIF1A
SCHEMBL7782036 0.89 CYP19A1 (0.65) CYP19A1TSHRMAPK1HIF1AMEN1
Chlorotriphenylmethane SCHEMBL461 0.86 TSHR (0.65) CYP19A1TSHRMAPK1CYP1A2
Chlorotriphenylmethane SCHEMBL16781670 0.86 TSHR (0.65) CYP19A1TSHRMAPK1CYP1A2
SCHEMBL3903209 0.84 TSHR (0.50) CYP19A1TSHRKIF11MAPK1HIF1A
SCHEMBL7646185 0.84 TSHR (0.50) CYP19A1TSHRKIF11MAPK1HIF1A
SCHEMBL9577502 0.84 TSHR (0.74) CYP19A1TSHRKIF11MAPK1HIF1A
Chlorotriphenylmethane SCHEMBL7567317 0.83 TSHR (0.61) CYP19A1TSHRMAPK1CYP1A2
Chlorotriphenylmethane SCHEMBL7246540 0.83 TSHR (0.61) CYP19A1TSHRMAPK1CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 938 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116808231-B Cell membrane penetrating peptide coupled sulpride prodrug system, preparation method and application 中国药科大学 2024-03-26 CN claimed
CN-114702380-B Method for co-producing p-chlorobenzoyl chloride and hexanoyl chloride and acyl chloride product thereof 河南特格纳特科技有限公司 2024-03-19 CN claimed
CN-117659122-A Carbon monoxide release molecule-transmembrane peptide complex and preparation and application thereof 中国人民解放军总医院 2024-03-08 CN claimed
CN-116808231-A Cell membrane penetrating peptide coupled sulpride prodrug system, preparation method and application 中国药科大学 2023-09-29 CN claimed
WO-2023082803-A1 ACTIVE POLYPEPTIDE FOR INHIBITING GROWTH OF LIVER CANCER CELLS, AND PREPARATION METHOD THEREFOR AND USE THEREOF 华南理工大学 2023-05-19 WO claimed
CN-110041407-B Method for synthesizing dessertraline acetate based on Fmoc dipeptide 南京肽业生物科技有限公司 2022-10-28 CN claimed
EP-3405476-B1 METHOD FOR PREPARATION OF PEPTIDES WITH psWANG LINKER POLYPEPTIDE LABORATORIES HOLDING PPL AB (SE) 2022-05-18 EP claimed
CN-114471005-A Cell-penetrating peptide transdermal absorption enhancer and preparation device thereof 赵彬 2022-05-13 CN claimed
US-11236123-B2 Method for preparation of peptides with psWang linker POLYPEPTIDE LABORATORIES HOLDING (PPL) AB (SE) 2022-02-01 US claimed
CN-113845571-A Active polypeptide for inhibiting growth of liver cancer cells and preparation method and application thereof 华南理工大学 2021-12-28 CN claimed
EP-1377589-A1 OXAZOLYL-PYRAZOLE DERIVATIVES AS KINASE INHIBITORS Pharmacia Italia S.p.A. (IT) 2004-01-07 EP claimed
EP-1373305-A1 PROCESS FOR PRODUCING TRUNKAMIDE A COMPOUNDS PHARMA MAR, S.A. (ES) 2004-01-02 EP claimed
WO-2003028720-A1 AMINOINDAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM PHARMACIA ITALIA S.P.A. (IT) 2003-04-10 WO claimed
WO-2002081506-A1 PROCESS FOR PRODUCING TRUNKAMIDE A COMPOUNDS PHARMA MAR, S.A. (ES) 2002-10-17 WO claimed
WO-2002062804-A1 OXAZOLYL-PYRAZOLE DERIVATIVES AS KINASE INHIBITORS PHARMACIA ITALIA S.P.A. (IT) 2002-08-15 WO claimed
EP-0937097-B1 COMPOSITIONS AND METHODS FOR IMMOBILIZING NUCLEIC ACIDS TO SOLID SUPPORTS SEQUENOM INC (US) 2001-08-16 EP claimed
JP-2001501967-A 2001-02-13 JP claimed
US-6133436-A INCREASED SURFACE AREA FOR IMMOBILIZATION OF NUCLEIC ACIDS; FOR USE IN HYBRIDIZATIONS SEQUENOM, INC. (US) 2000-10-17 US claimed
EP-0937097-A1 COMPOSITIONS AND METHODS FOR IMMOBILIZING NUCLEIC ACIDS TO SOLID SUPPORTS SEQUENOM, INC. (US) 1999-08-25 EP claimed
WO-1998020019-A1 COMPOSITIONS AND METHODS FOR IMMOBILIZING NUCLEIC ACIDS TO SOLID SUPPORTS SEQUENOM, INC. (US) 1998-05-14 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11236123-B2 Method for preparation of peptides with psWang linker VIP, GLP1R, IAPP CYP19A1 4442/4885TSHR 852/4885KIF11 2405/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.