Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Azelastine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 known ✓ | P35367 | 17/20 | 1.00 |
| ▸ | ADRA1A | P35348 | 17/20 | 1.00 |
| ▸ | ADRA1B | P35368 | 17/20 | 1.00 |
| ▸ | ADRA2A | P08913 | 2/20 | 1.00 |
| ▸ | CHRM1 | P11229 | 2/20 | 1.00 |
| ▸ | ADRA2B | P18089 | 2/20 | 1.00 |
| ▸ | HTR2A | P28223 | 2/20 | 1.00 |
| ▸ | DRD3 | P35462 | 2/20 | 1.00 |
| ▸ | LMNA | P02545 | 1/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 1/20 | 1.00 |
| ▸ | DRD2 | P14416 | 1/20 | 1.00 |
| ▸ | DRD1 | P21728 | 1/20 | 1.00 |
| ▸ | ADRA1D | P25100 | 1/20 | 1.00 |
| ▸ | HTR1D | P28221 | 1/20 | 1.00 |
| ▸ | HTR1B | P28222 | 1/20 | 1.00 |
| ▸ | HTR1E | P28566 | 1/20 | 1.00 |
| ▸ | HTR7 | P34969 | 1/20 | 1.00 |
| ▸ | HTR6 | P50406 | 1/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 1.00 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Azelastine SCHEMBL29375717 | 1.00 | ADRA1A (1.00) | ADRA1AHRH1ADRA1BADRA2ACHRM1 | |
| Azelastine SCHEMBL19458799 | 1.00 | ADRA1A (1.00) | ADRA1AHRH1ADRA1BADRA2ACHRM1 | |
| Azelastine SCHEMBL36770 | 1.00 | ADRA1A (1.00) | ADRA1AHRH1ADRA1BADRA2ACHRM1 | |
| Azelastine SCHEMBL4239 | 0.99 | ADRA1A (1.00) | ADRA1AHRH1ADRA1BADRA2ACHRM1 | |
| Azelastine SCHEMBL17223862 | 0.99 | ADRA1A (1.00) | ADRA1AHRH1ADRA1BADRA2ACHRM1 | |
| Azelastine SCHEMBL30910968 | 0.99 | ADRA1A (1.00) | ADRA1AHRH1ADRA1BADRA2ACHRM1 | |
| Azelastine SCHEMBL4240 | 0.99 | ADRA1A (1.00) | ADRA1AHRH1ADRA1BADRA2ACHRM1 | |
| Azelastine SCHEMBL4433245 | 0.99 | ADRA1A (1.00) | ADRA1AHRH1ADRA1BADRA2ACHRM1 | |
| Azelastine SCHEMBL17803891 | 0.99 | ADRA1A (1.00) | ADRA1AHRH1ADRA1BADRA2ACHRM1 | |
| Azelastine SCHEMBL29370712 | 0.99 | ADRA1A (1.00) | ADRA1AHRH1ADRA1BADRA2ACHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 3486 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260076872-A1 | POLYMER VIALS WITH SUBSTANTIALLY FLAT BOTTOMS AND INJECTION STRETCH BLOW MOLDING METHODS FOR MAKING THE SAME | SIO2 MEDICAL PRODUCTS LLC (US) | 2026-03-19 | — | — | US | claimed |
| EP-4674454-A1 | LIQUID PREPARATION FOR ATOMIZATION IN ELECTRONIC ATOMIZER, CARTRIDGE AND AEROSOL GENERATION SYSTEM | Shenzhen First Union Technology Co., Ltd. (CN) | 2026-01-07 | — | — | EP | claimed |
| US-20250242092-A1 | SiOx BARRIER FOR PHARMACEUTICAL PACKAGE AND COATING PROCESS | SIO2 MEDICAL PRODUCTS INC (US) | 2025-07-31 | — | — | US | claimed |
| EP-4590283-A1 | MUCOADHESIVE DRUG DELIVERY SYSTEMS AND METHODS OF USE | Madd Ophthalmics Ltd. (CA) | 2025-07-30 | — | — | EP | claimed |
| CN-119950514-A | Application of azelastine hydrochloride or pharmaceutically acceptable salt thereof in preparation of medicines for treating or improving allergic purpura | 贵州云峰药业有限公司 | 2025-05-09 | — | — | CN | claimed |
| CN-119874617-A | Preparation method of azelastine hydrochloride intermediate | 贵州云峰药业有限公司 | 2025-04-25 | — | — | CN | claimed |
| CN-119837829-A | Azelastine hydrochloride nasal spray and preparation method thereof | 广州市桐晖药业有限公司 | 2025-04-18 | — | — | CN | claimed |
| US-12257371-B2 | SiOx barrier for pharmaceutical package and coating process | SIO2 MEDICAL PRODUCTS, LLC (US) | 2025-03-25 | — | — | US | claimed |
| CN-119345125-B | Azelastine hydrochloride eye drops | 广州市桐晖药业有限公司 | 2025-03-14 | — | — | CN | claimed |
| CN-119564865-A | Application of combined medicine in preparation of medicine for treating drug eruption | 贵州云峰药业有限公司 | 2025-03-07 | — | — | CN | claimed |
| EP-1161956-A1 | MEDICINAL COMPOSITIONS | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2001-12-12 | — | — | EP | claimed |
| WO-2001083517-A1 | STAT4 AND STAT6 BINDING DIPEPTIDE DERIVATIVES | TULARIK INC. (US) | 2001-11-08 | — | — | WO | claimed |
| US-6299888-B1 | FOR THERAPY OF BRONCHIAL ASTHMA, URTICARIA, AND PRURITUS | TEIKOKU SEIYAKU KABUSHIKI KAISHA (JP) | 2001-10-09 | — | — | US | claimed |
| EP-0659744-B1 | Process of preparation of hexahydroazepinones and hexahydroazepinoles | ASTA MEDICA AG (DE) | 2001-02-28 | — | — | EP | claimed |
| US-6117864-A | ADMINISTERING EXTERNALLY NON-IRRITATING HOMOGENEOUS DRUG COMPRISING AZELASTINE SALT AND STABILIZING AMOUNT OF FATTY ACID SELECTED FROM CAPRIC ACID, LAURIC ACID, MYRISTIC PALMITIC ACID, STEARIC ACID, ISOSTEARIC ACID, BEHENIC ACID | ASTA MEDICA AKTIENGESELLSCHAFT (DE) | 2000-09-12 | — | — | US | claimed |
| EP-0958823-A1 | AZELASTINE HYDROCHLORIDE-CONTAINING PERCUTANEOUS PREPARATION HAVING GOOD PERCUTANEOUS ABSORBABILITY AND REDUCED SKIN IRRITATION | TEIKOKU SEIYAKU KABUSHIKI KAISHA (JP) | 1999-11-24 | — | — | EP | claimed |
| US-5811547-A | Method for inducing crystalline state transition in medicinal substance | NIPPON SHINYAJU CO., LTD. (JP) | 1998-09-22 | — | — | US | claimed |
| EP-0580074-B1 | Stable preparation containing azelastine hydrochloride | ASTA MEDICA AG (DE) | 1995-01-18 | — | — | EP | claimed |
| EP-0580074-A1 | Stable preparation containing azelastine hydrochloride | ASTA Medica Aktiengesellschaft (DE) | 1994-01-26 | — | — | EP | claimed |
| EP-0551626-A1 | Thermoreversible gel as a liquid pharmaceutical carrier for a galenic formulation | LEK, tovarna farmacevtskih in kemicnih izdelkov, d.d. (SI) | 1993-07-21 | — | — | EP | claimed |