Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Azelastine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 known ✓ | P35367 | 17/20 | 1.00 |
| ▸ | ADRA1A | P35348 | 17/20 | 1.00 |
| ▸ | ADRA1B | P35368 | 17/20 | 1.00 |
| ▸ | ADRA2A | P08913 | 2/20 | 1.00 |
| ▸ | CHRM1 | P11229 | 2/20 | 1.00 |
| ▸ | ADRA2B | P18089 | 2/20 | 1.00 |
| ▸ | HTR2A | P28223 | 2/20 | 1.00 |
| ▸ | DRD3 | P35462 | 2/20 | 1.00 |
| ▸ | LMNA | P02545 | 1/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 1/20 | 1.00 |
| ▸ | DRD2 | P14416 | 1/20 | 1.00 |
| ▸ | DRD1 | P21728 | 1/20 | 1.00 |
| ▸ | ADRA1D | P25100 | 1/20 | 1.00 |
| ▸ | HTR1D | P28221 | 1/20 | 1.00 |
| ▸ | HTR1B | P28222 | 1/20 | 1.00 |
| ▸ | HTR1E | P28566 | 1/20 | 1.00 |
| ▸ | HTR7 | P34969 | 1/20 | 1.00 |
| ▸ | HTR6 | P50406 | 1/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 1.00 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Azelastine SCHEMBL36770 | 1.00 | ADRA1A (1.00) | ADRA1AHRH1ADRA1BADRA2ACHRM1 | |
| Azelastine SCHEMBL36771 | 1.00 | ADRA1A (1.00) | ADRA1AHRH1ADRA1BADRA2ACHRM1 | |
| Azelastine SCHEMBL29375717 | 1.00 | ADRA1A (1.00) | ADRA1AHRH1ADRA1BADRA2ACHRM1 | |
| Azelastine SCHEMBL4240 | 0.99 | ADRA1A (1.00) | ADRA1AHRH1ADRA1BADRA2ACHRM1 | |
| Azelastine SCHEMBL4239 | 0.99 | ADRA1A (1.00) | ADRA1AHRH1ADRA1BADRA2ACHRM1 | |
| Azelastine SCHEMBL4433245 | 0.99 | ADRA1A (1.00) | ADRA1AHRH1ADRA1BADRA2ACHRM1 | |
| Azelastine SCHEMBL17223862 | 0.99 | ADRA1A (1.00) | ADRA1AHRH1ADRA1BADRA2ACHRM1 | |
| Azelastine SCHEMBL17803891 | 0.99 | ADRA1A (1.00) | ADRA1AHRH1ADRA1BADRA2ACHRM1 | |
| Azelastine SCHEMBL30910968 | 0.99 | ADRA1A (1.00) | ADRA1AHRH1ADRA1BADRA2ACHRM1 | |
| Azelastine SCHEMBL29370712 | 0.99 | ADRA1A (1.00) | ADRA1AHRH1ADRA1BADRA2ACHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10722477-B2 | Cooling adjunct for medications to treat disorders in the nasal cavity | WEI, EDWARD T. | 2020-07-28 | — | — | US | disclosed |
| US-20170296489-A1 | Cooling Adjunct For Medications To Treat Disorders In The Nasal Cavity | WEI, EDWARD T. | 2017-10-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170296489-A1 | Cooling Adjunct For Medications To Treat Disorders In The Nasal Cavity | TRPA1, TRPV1, TSLP | HRH1 7/4885ADRA1A 5/4885ADRA1B 91/4885 |
| US-10722477-B2 | Cooling adjunct for medications to treat disorders in the nasal cavity | TRPA1, TRPV1, TSLP | HRH1 7/4885ADRA1A 5/4885ADRA1B 91/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.