Known targets — ChEMBL curated mechanism
CACNA1CCACNA1DCACNA1FCACNA1SDPP4HTR1BHTR1D
The experimentally established mechanism targets of Benzoic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 2/20 | 0.42 |
| ▸ | CES1 | P23141 | 2/20 | 0.42 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.41 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.41 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.40 |
| ▸ | PTGER4 | P35408 | 3/20 | 0.39 |
| ▸ | PTGER2 | P43116 | 3/20 | 0.39 |
| ▸ | GPR84 | Q9NQS5 | 4/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Benzoic Acid SCHEMBL3680775 | 0.96 | CES2 (0.40) | CES2CES1PLA2G4B | |
| Benzoic Acid SCHEMBL569738 | 0.89 | PLA2G4B (0.48) | CES2CES1FFAR4FFAR1PLA2G4B | |
| Benzoic Acid SCHEMBL28285786 | 0.85 | RARB (0.45) | CES2CES1PLA2G4BPTGER4PTGER2 | |
| Benzoic Acid SCHEMBL569810 | 0.84 | TSHR (0.48) | CES2CES1PLA2G4B | |
| Benzoic Acid SCHEMBL569372 | 0.82 | ALDH1A1 (0.45) | CES2CES1FFAR4FFAR1PLA2G4B | |
| Benzoic Acid SCHEMBL3690253 | 0.82 | TSHR (0.45) | CES2CES1PLA2G4B | |
| Benzoic Acid SCHEMBL28711585 | 0.81 | FFAR4 (0.56) | CES2CES1FFAR4FFAR1PLA2G4B | |
| Benzoic Acid SCHEMBL27846691 | 0.81 | FFAR4 (0.56) | CES2CES1FFAR4FFAR1PLA2G4B | |
| Benzoic Acid SCHEMBL10946836 | 0.81 | FFAR4 (0.56) | CES2CES1FFAR4FFAR1PLA2G4B | |
| Benzoic Acid SCHEMBL571002 | 0.81 | ALDH1A1 (0.47) | CES2CES1FFAR4FFAR1PLA2G4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2185600-A1 | SELF-LIMITING CATALYST COMPOSITION WITH NO SILANE | Dow Global Technologies Inc. (US) | 2010-05-19 | — | — | EP | disclosed |
| WO-2009029447-A1 | SELF-LIMITING CATALYST COMPOSITION WITH NO SILANE | DOW GLOBAL TECHNOLOGIES INC. (US) | 2009-03-05 | — | — | WO | disclosed |