Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Lysine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 known ✓ | P23219 | 2/20 | 0.47 |
| ▸ | GSR | P00390 | 2/20 | 0.59 |
| ▸ | GSTK1 | Q9Y2Q3 | 1/20 | 0.47 |
| ▸ | CPB2 | Q96IY4 | 2/20 | 0.45 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.43 |
| ▸ | RNPEP | Q9H4A4 | 1/20 | 0.41 |
| ▸ | ARG2 | P78540 | 4/20 | 0.39 |
| ▸ | ARG1 | P05089 | 3/20 | 0.39 |
| ▸ | SLC7A11 | Q9UPY5 | 1/20 | 0.39 |
| ▸ | GRM8 | O00222 | 1/20 | 0.37 |
| ▸ | GRM6 | O15303 | 1/20 | 0.37 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.37 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.37 |
| ▸ | GRM5 | P41594 | 1/20 | 0.37 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.37 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.37 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.37 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lysine SCHEMBL27944317 | 1.00 | GSR (0.59) | GSRPTGS1GSTK1CPB2FOLH1 | |
| Lysine SCHEMBL1042959 | 1.00 | GSR (0.59) | GSRPTGS1GSTK1CPB2FOLH1 | |
| Lysine SCHEMBL6301386 | 1.00 | GSR (0.59) | GSRPTGS1GSTK1CPB2FOLH1 | |
| Lysine SCHEMBL6301384 | 1.00 | GSR (0.59) | GSRPTGS1GSTK1CPB2FOLH1 | |
| Lysine SCHEMBL9574568 | 0.99 | GSR (0.57) | GSRPTGS1GSTK1CPB2FOLH1 | |
| Lysine SCHEMBL9118672 | 0.87 | GSR (0.61) | GSRPTGS1GSTK1CPB2FOLH1 | |
| Cysteine SCHEMBL28399079 | 0.82 | PTGS1 (0.59) | GSRPTGS1GSTK1FOLH1SLC7A11 | |
| SCHEMBL4158587 | 0.82 | FOLH1 (0.50) | GSRPTGS1GSTK1CPB2FOLH1 | |
| SCHEMBL31448267 | 0.81 | GSR (0.50) | GSRARG2ARG1GRM8GRM6 | |
| SCHEMBL43620 | 0.81 | FOLH1 (0.57) | GSRCPB2FOLH1RNPEP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0546272-B1 | S-carboxymethylcysteine lysine salt monohydrate and a process for the preparation thereof | DOMPE FARMACEUTICI SPA (IT) | 1996-02-28 | — | — | EP | claimed |
| EP-0546272-A1 | S-carboxymethylcysteine lysine salt monohydrate and a process for the preparation thereof | DOMPE' FARMACEUTICI S.p.A. (IT) | 1993-06-16 | — | — | EP | claimed |
| US-8703750-B2 | Mixtures and methods for the induction of resistance in plants | ISAGRO S.P.A. (IT) | 2014-04-22 | — | — | US | disclosed |
| US-20100317519-A1 | Mixtures and methods for the induction of resistance in plants | ISAGRO S.P.A. (IT) | 2010-12-16 | — | — | US | disclosed |
| US-20070173459-A1 | Mixtures and methods for the induction of resistance in plants | ISAGRO S.P.A. (IT) | 2007-07-26 | — | — | US | disclosed |
| EP-1720408-A1 | MIXTURES AND METHODS FOR THE INDUCTION OF RESISTANCE IN PLANTS | ISAGRO S.p.A. (IT) | 2006-11-15 | — | — | EP | disclosed |
| WO-2005094580-A1 | MIXTURES AND METHODS FOR THE INDUCTION OF RESISTANCE IN PLANTS | ISAGRO S.P.A. (IT) | 2005-10-13 | — | — | WO | disclosed |
| EP-0546272-B1 | S-carboxymethylcysteine lysine salt monohydrate and a process for the preparation thereof | DOMPE FARMACEUTICI SPA (IT) | 1996-02-28 | — | — | EP | disclosed |
| EP-0546272-B1 | S-carboxymethylcysteine lysine salt monohydrate and a process for the preparation thereof | DOMPE FARMACEUTICI SPA (IT) | 1996-02-28 | — | — | EP | disclosed |
| EP-0546272-A1 | S-carboxymethylcysteine lysine salt monohydrate and a process for the preparation thereof | DOMPE' FARMACEUTICI S.p.A. (IT) | 1993-06-16 | — | — | EP | disclosed |
| EP-0546272-A1 | S-carboxymethylcysteine lysine salt monohydrate and a process for the preparation thereof | DOMPE' FARMACEUTICI S.p.A. (IT) | 1993-06-16 | — | — | EP | disclosed |
| EP-0546272-A1 | S-carboxymethylcysteine lysine salt monohydrate and a process for the preparation thereof | DOMPE' FARMACEUTICI S.p.A. (IT) | 1993-06-16 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070173459-A1 | Mixtures and methods for the induction of resistance in plants | SLC11A2, MYD88, ME2 | PTGS1 80/4885GSR 35/4885GSTK1 454/4885 |
| US-20100317519-A1 | Mixtures and methods for the induction of resistance in plants | SLC11A2, MYD88, ME2 | PTGS1 80/4885GSR 35/4885GSTK1 454/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.