Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FOLH1 | Q04609 | 2/20 | 0.50 |
| ▸ | CPB2 | Q96IY4 | 6/20 | 0.45 |
| ▸ | ACE | P12821 | 1/20 | 0.45 |
| ▸ | RNPEP | Q9H4A4 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | THPO | P40225 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.41 |
| ▸ | GSTK1 | Q9Y2Q3 | 1/20 | 0.41 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.40 |
| ▸ | SLC15A2 | Q16348 | 1/20 | 0.40 |
| ▸ | GNPAT | O15228 | 1/20 | 0.39 |
| ▸ | GSR | P00390 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL43620 | 0.84 | FOLH1 (0.57) | FOLH1CPB2RNPEPTHRBALOX15 | |
| SCHEMBL929284 | 0.84 | ACE (0.56) | FOLH1ACEKDM4EMAPTTHRB | |
| SCHEMBL50111 | 0.84 | FOLH1 (0.57) | FOLH1CPB2RNPEPTHRBALOX15 | |
| Water SCHEMBL28073715 | 0.82 | FOLH1 (0.56) | FOLH1CPB2RNPEPTHRBALOX15 | |
| SCHEMBL28109489 | 0.82 | FOLH1 (0.56) | FOLH1CPB2RNPEPTHRBALOX15 | |
| SCHEMBL380767 | 0.82 | FOLH1 (0.56) | FOLH1CPB2RNPEPTHRBALOX15 | |
| SCHEMBL901403 | 0.82 | FOLH1 (0.56) | FOLH1CPB2RNPEPTHRBALOX15 | |
| Water SCHEMBL380638 | 0.82 | FOLH1 (0.56) | FOLH1CPB2RNPEPTHRBALOX15 | |
| Lysine SCHEMBL6301384 | 0.82 | GSR (0.59) | FOLH1CPB2RNPEPPTGS1GSTK1 | |
| Lysine SCHEMBL1042959 | 0.82 | GSR (0.59) | FOLH1CPB2RNPEPPTGS1GSTK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1933642-B1 | SALT ENHANCING COMPOUNDS AND USE | HOFMANN THOMAS FRANK (DE) | 2011-12-21 | — | — | EP | claimed |
| US-20090155440-A1 | Salt Enhancing Compounds and Use | GIVAUDAN SA (CH) | 2009-06-18 | — | — | US | claimed |
| EP-1933642-A1 | SALT ENHANCING COMPOUNDS AND USE | Thomas Frank Hofmann & Andreas Dunkel Inst. für Lebensmittelchemie (DE) | 2008-06-25 | — | — | EP | claimed |
| WO-2007042274-A1 | SALT ENHANCING COMPOUNDS AND USE | THOMAS FRANK HOFMANN & ANDREAS DUNKEL (DE) | 2007-04-19 | — | — | WO | claimed |
| US-20240114942-A1 | Antagonists of T2R54 and Compositions and Uses Thereof | FIRMENICH INCORPORATED (US) | 2024-04-11 | — | — | US | disclosed |
| US-20240108040-A1 | HIGH INTENSITY SWEETENERS | FIRMENICH INCORPORATED (US) | 2024-04-04 | — | — | US | disclosed |
| US-11871772-B2 | Antagonists of T2R54 and compositions and uses thereof | FIRMENICH INCORPORATED (US) | 2024-01-16 | — | — | US | disclosed |
| US-11758933-B2 | High intensity sweeteners | FIRMENICH INCORPORATED (US) | 2023-09-19 | — | — | US | disclosed |
| EP-3368542-B1 | HIGH INTENSITY SWEETENERS | FIRMENICH INCORPORATED (US) | 2022-06-22 | — | — | EP | disclosed |
| US-11357246-B2 | High intensity sweeteners | FIRMENICH INCORPORATED (US) | 2022-06-14 | — | — | US | disclosed |
| CN-113194742-A | Antagonists of T2R54 and their compositions and uses | 弗门尼舍公司 | 2021-07-30 | — | — | CN | disclosed |
| US-20210227863-A1 | HIGH INTENSITY SWEETENERS | SENOMYX, INC. | 2021-07-29 | — | — | US | disclosed |
| WO-2017075257-A2 | HIGH INTENSITY SWEETENERS | SENOMYX, INC. (US) | 2017-05-04 | — | — | WO | disclosed |
| US-20170096418-A1 | COMPOUNDS USEFUL AS MODULATORS OF TRPM8 | FIRMENICH INCORPORATED | 2017-04-06 | — | — | US | disclosed |
| US-20170087199-A1 | COMPOSITIONS FOR DELIVERING A COOLING SENSATION | SENOMYX INC (US) | 2017-03-30 | — | — | US | disclosed |
| US-20160376263-A1 | BITTER TASTE MODIFIERS INCLUDING SUBSTITUTED 1-BENZYL-3-(1-(ISOXAZOL-4-YLMETHYL)-1H-PYRAZOL-4-YL)IMIDAZOLIDINE-2,4-DIONES AND COMPOSITIONS THEREOF | SENOMYX INC (US) | 2016-12-29 | — | — | US | disclosed |
| EP-1933642-B1 | SALT ENHANCING COMPOUNDS AND USE | HOFMANN THOMAS FRANK (DE) | 2011-12-21 | — | — | EP | disclosed |
| US-20090155440-A1 | Salt Enhancing Compounds and Use | GIVAUDAN SA (CH) | 2009-06-18 | — | — | US | disclosed |
| EP-1933642-A1 | SALT ENHANCING COMPOUNDS AND USE | Thomas Frank Hofmann & Andreas Dunkel Inst. für Lebensmittelchemie (DE) | 2008-06-25 | — | — | EP | disclosed |
| WO-2007042274-A1 | SALT ENHANCING COMPOUNDS AND USE | THOMAS FRANK HOFMANN & ANDREAS DUNKEL (DE) | 2007-04-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240108040-A1 | HIGH INTENSITY SWEETENERS | TAS2R40, TAS2R60, TAS1R1 | FOLH1 1289/4885CPB2 4610/4885ACE 1643/4885 |
| US-11871772-B2 | Antagonists of T2R54 and compositions and uses thereof | TAS2R50, TAS2R30, TAS2R60 | FOLH1 1173/4885CPB2 4181/4885ACE 3505/4885 |
| US-20160376263-A1 | BITTER TASTE MODIFIERS INCLUDING SUBSTITUTED 1-BENZYL-3-(1-(ISOXAZOL-4-YLMETHYL)-1H-PYRAZOL-4-YL)IMIDAZOLIDINE-2,4-DIONES AND COMPOSITIONS THEREOF | TAS2R5, TAS1R1, TAS2R1 | FOLH1 3400/4885CPB2 4702/4885ACE 3991/4885 |
| US-11357246-B2 | High intensity sweeteners | TAS2R40, TAS2R60, TAS1R1 | FOLH1 1289/4885CPB2 4610/4885ACE 1643/4885 |
| US-20090155440-A1 | Salt Enhancing Compounds and Use | TAS1R1, TAS2R41, TAS2R40 | FOLH1 651/4885CPB2 2327/4885ACE 247/4885 |
| US-20240114942-A1 | Antagonists of T2R54 and Compositions and Uses Thereof | TAS2R50, TAS2R30, TAS2R60 | FOLH1 1173/4885CPB2 4181/4885ACE 3505/4885 |
| US-20170087199-A1 | COMPOSITIONS FOR DELIVERING A COOLING SENSATION | TRPA1, PDE6G, PDE6D | FOLH1 3426/4885CPB2 3054/4885ACE 445/4885 |
| US-20210227863-A1 | HIGH INTENSITY SWEETENERS | TAS2R40, TAS2R60, TAS1R1 | FOLH1 1289/4885CPB2 4610/4885ACE 1643/4885 |
| US-11758933-B2 | High intensity sweeteners | TAS2R40, TAS2R60, TAS1R1 | FOLH1 1289/4885CPB2 4610/4885ACE 1643/4885 |
| US-20170096418-A1 | COMPOUNDS USEFUL AS MODULATORS OF TRPM8 | TRPM8, TRPM6, TRPM4 | FOLH1 2680/4885CPB2 3191/4885ACE 4707/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.