Known targets — ChEMBL curated mechanism
ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1GSK3AGSK3BHRH1HRH2HTR7IDH1IDH2IMPA1IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA4 | P22748 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | HMGCR | P04035 | 1/20 | 0.44 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.44 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | APEX1 | P27695 | 1/20 | 0.33 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.33 |
| ▸ | CPT2 | P23786 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | SLC13A5 | Q86YT5 | 2/20 | 0.33 |
| ▸ | ACLY | P53396 | 2/20 | 0.32 |
| ▸ | BBOX1 | O75936 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Citric Acid SCHEMBL7083476 | 0.98 | CA4 (0.50) | CA4ALDH1A1HMGCRCHRM1TBXA2R | |
| Citric Acid SCHEMBL107472 | 0.94 | CA4 (0.64) | CA4ALDH1A1HMGCRCHRM1TBXA2R | |
| Citric Acid SCHEMBL28164924 | 0.90 | CA4 (0.64) | CA4ALDH1A1HMGCRCHRM1TBXA2R | |
| Citric Acid SCHEMBL183004 | 0.87 | CA4 (0.59) | CA4ALDH1A1HMGCRCHRM1TBXA2R | |
| Citric Acid SCHEMBL2890971 | 0.87 | CA4 (0.67) | CA4ALDH1A1HMGCRCHRM1TBXA2R | |
| Citric Acid SCHEMBL5190913 | 0.87 | CA4 (0.59) | CA4ALDH1A1HMGCRCHRM1TBXA2R | |
| Citric Acid SCHEMBL7519382 | 0.87 | CA4 (0.59) | CA4ALDH1A1HMGCRCHRM1TBXA2R | |
| Citric Acid SCHEMBL33988 | 0.87 | CA4 (0.59) | CA4ALDH1A1HMGCRCHRM1TBXA2R | |
| Citric Acid SCHEMBL10477647 | 0.87 | CA4 (0.67) | CA4ALDH1A1HMGCRCHRM1TBXA2R | |
| Citric Acid SCHEMBL1684058 | 0.87 | CA4 (0.59) | CA4ALDH1A1HMGCRCHRM1TBXA2R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 251 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230357750-A1 | Method for Treating a Biological Sample, and Device for Isolating Cells from a Transport Medium | ROBERT BOSCH GMBH (DE) | 2023-11-09 | — | — | US | claimed |
| EP-4118201-A1 | METHOD FOR TREATING A BIOLOGICAL SAMPLE, AND DEVICE FOR ISOLATING CELLS FROM A TRANSPORT MEDIUM | Robert Bosch GmbH (DE) | 2023-01-18 | — | — | EP | claimed |
| CN-115190913-A | Method for processing biological samples and device for separating cells from transport medium | 罗伯特·博世有限公司 | 2022-10-14 | — | — | CN | claimed |
| CN-104870625-A | Improved structuring using an external structurant and a cosmotrope | PROCTER & GAMBLE | 2015-08-26 | — | — | CN | claimed |
| WO-2014099852-A1 | IMPROVED STRUCTURING USING AN EXTERNAL STRUCTURANT AND A COSMOTROPE | THE PROCTER & GAMBLE COMPANY (US) | 2014-06-26 | — | — | WO | claimed |
| US-20140179591-A1 | STRUCTURING USING AN EXTERNAL STRUCTURANT AND A COSMOTROPE | THE PROCTER & GAMBLE COMPANY (US) | 2014-06-26 | — | — | US | claimed |
| EP-2746377-A1 | Improved structuring using an external structurant and a cosmotrope | The Procter & Gamble Company (US) | 2014-06-25 | — | — | EP | claimed |
| CN-103079407-A | Improved insecticidal compositions comprising cyclic carboximidamidines | BAYER CROPSCIENCE AG | 2013-05-01 | — | — | CN | claimed |
| US-20120004268-A1 | INSECTICIDAL COMPOSITIONS COMPRISING CYCLIC CARBONYLAMIDINES | BAYER CROPSCIENCE AG (DE) | 2012-01-05 | — | — | US | claimed |
| US-8053479-B2 | Silica sol and method for producing the same | FUSO CHEMICAL CO. LTD. (JP) | 2011-11-08 | — | — | US | claimed |
| US-7468105-B2 | CMP cleaning composition with microbial inhibitor | MICRON TECHNOLOGY, INC. (US) | 2008-12-23 | — | — | US | claimed |
| US-20070160857-A1 | Cobalt-based alloy electroless planting solution and electroless plating method using the same | LG CHEM, LTD. (KR) | 2007-07-12 | — | — | US | claimed |
| EP-1128222-B1 | Photoresist stripping composition | SHIPLEY CO LLC (US) | 2007-05-23 | — | — | EP | claimed |
| US-7205233-B2 | Method for forming CoWRe alloys by electroless deposition | APPLIED MATERIALS, INC. (US) | 2007-04-17 | — | — | US | claimed |
| US-20050101130-A1 | Method and tool of chemical doping CoW alloys with Re for increasing barrier properties of electroless capping layers for IC Cu interconnects | APPLIED MATERIALS, INC. | 2005-05-12 | — | — | US | claimed |
| US-20030089891-A1 | CMP cleaning composition with microbial inhibitor | MICRON TECHNOLOGY, INC. | 2003-05-15 | — | — | US | claimed |
| US-6531436-B1 | Polymer removal | SHIPLEY COMPANY, L.L.C. | 2003-03-11 | — | — | US | claimed |
| US-6528409-B1 | Interconnect structure formed in porous dielectric material with minimized degradation and electromigration | ADVANCED MICRO DEVICES, INC. | 2003-03-04 | — | — | US | claimed |
| EP-1128222-A2 | Photoresist stripping composition | Shipley Company LLC (US) | 2001-08-29 | — | — | EP | claimed |
| EP-1128221-A2 | Plasma Etching residue removal | Shipley Company LLC (US) | 2001-08-29 | — | — | EP | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120004268-A1 | INSECTICIDAL COMPOSITIONS COMPRISING CYCLIC CARBONYLAMIDINES | DDT, PRMT9, PNISR | CA4 1808/4885ALDH1A1 4218/4885HMGCR 4673/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.