Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 1/20 | 0.60 |
| ▸ | DPP4 | P27487 | 1/20 | 0.58 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.58 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.58 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.58 |
| ▸ | EPHX2 | P34913 | 9/20 | 0.58 |
| ▸ | FAAH | O00519 | 7/20 | 0.58 |
| ▸ | RAF1 | P04049 | 1/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.56 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.54 |
| ▸ | HPGDS | O60760 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.52 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11820779 | 0.94 | MCHR1 (0.55) | MCHR1DPP4DPP8DPP9DPP7 | |
| SCHEMBL6455818 | 0.93 | SMYD3 (0.58) | MCHR1DPP4DPP8DPP9DPP7 | |
| SCHEMBL6455822 | 0.93 | SMYD3 (0.58) | MCHR1DPP4DPP8DPP9DPP7 | |
| SCHEMBL11814856 | 0.90 | EPHX2 (0.52) | MCHR1DPP4DPP8DPP9DPP7 | |
| SCHEMBL2517888 | 0.84 | EPHX1 (0.58) | MCHR1DPP4DPP8DPP9DPP7 | |
| SCHEMBL10294129 | 0.84 | RAB9A (0.55) | MCHR1HPGDSMEN1NPC1RAB9A | |
| SCHEMBL11822388 | 0.83 | MCHR1 (0.47) | MCHR1DPP4DPP8DPP9DPP7 | |
| SCHEMBL1424870 | 0.82 | HSD11B1 (0.69) | DPP4DPP8DPP9DPP7EPHX2 | |
| SCHEMBL2472926 | 0.82 | TAS1R3 (0.67) | MCHR1EPHX2L3MBTL1HPGDSNPC1 | |
| SCHEMBL23390110 | 0.81 | F2R (0.55) | DPP4DPP8DPP9DPP7EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2173735-A1 | IMIDAZOLE DERIVATIVES AS CCR2 RECEPTOR ANTAGONISTS | F. Hoffmann-Roche AG (CH) | 2010-04-14 | — | — | EP | disclosed |
| WO-2009003861-A1 | IMIDAZOLE DERIVATIVES AS CCR2 RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2009-01-08 | — | — | WO | disclosed |