Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 7/20 | 0.51 |
| ▸ | EGFR | P00533 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | RORC | P51449 | 1/20 | 0.39 |
| ▸ | SRC | P12931 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17423697 | 0.80 | EGFR (0.47) | AGTR1EGFRALDH1A1POLBKDM4E | |
| SCHEMBL28246406 | 0.79 | EGFR (0.63) | AGTR1EGFRALDH1A1POLBKDM4E | |
| SCHEMBL30344008 | 0.76 | POLB (0.64) | AGTR1ALDH1A1POLBKDM4EHPGD | |
| SCHEMBL1180653 | 0.76 | POLB (0.64) | AGTR1ALDH1A1POLBKDM4EHPGD | |
| SCHEMBL3677753 | 0.75 | POLB (0.44) | AGTR1ALDH1A1POLBKDM4EHPGD | |
| SCHEMBL28287105 | 0.75 | POLB (0.44) | ALDH1A1POLBKDM4EHPGDP2RX4 | |
| SCHEMBL784606 | 0.75 | POLB (0.49) | AGTR1EGFRALDH1A1POLBKDM4E | |
| SCHEMBL16340217 | 0.75 | ALDH1A1 (0.48) | ALDH1A1POLBKDM4EHPGDP2RX4 | |
| SCHEMBL28208533 | 0.71 | POLB (0.48) | ALDH1A1POLBKDM4EHPGDP2RX4 | |
| SCHEMBL2424796 | 0.71 | P2RX4 (0.69) | AGTR1ALDH1A1POLBKDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2170072-A1 | FARNESOID X RECEPTOR AGONISTS | GlaxoSmithKline LLC (US) | 2010-04-07 | — | — | EP | disclosed |
| WO-2008157270-A1 | FARNESOID X RECEPTOR AGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-12-24 | — | — | WO | disclosed |