SCHEMBL3679747

SCHEMBL3679747

Cc1ccccc1C(=O)Nc1cccc2ccccc12

nearest known ligand 0.68

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 4/20 0.68
RAB9A P51151 4/20 0.68
ALDH1A1 P00352 4/20 0.67
GAA P10253 3/20 0.67
SMN1; SMN2 Q16637 2/20 0.67
MEN1 O00255 1/20 0.67
TP53 P04637 1/20 0.67
NFKB1 P19838 1/20 0.67
NFKB2 Q00653 1/20 0.67
KMT2A Q03164 1/20 0.67
RELA Q04206 1/20 0.67
PARP1 P09874 1/20 0.64
CHRNB2 P17787 1/20 0.64
CHRNB4 P30926 1/20 0.64
CHRNA3 P32297 1/20 0.64
CHRNA4 P43681 1/20 0.64
CYP1A2 P05177 1/20 0.61
CYP3A4 P08684 1/20 0.61
CYP2D6 P10635 1/20 0.61
CYP2C9 P11712 1/20 0.61

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30260457 1.00 NPC1 (0.68) NPC1RAB9AALDH1A1GAASMN1; SMN2
SCHEMBL3182095 0.87 ALDH1A1 (0.67) NPC1RAB9AALDH1A1GAASMN1; SMN2
SCHEMBL21275460 0.86 RAB9A (0.76) NPC1RAB9AALDH1A1GAASMN1; SMN2
SCHEMBL30987374 0.84 ALDH1A1 (0.64) ALDH1A1SMN1; SMN2MEN1KMT2APARP1
SCHEMBL12218084 0.84 NPC1 (0.68) NPC1RAB9AALDH1A1GAASMN1; SMN2
SCHEMBL24004522 0.83 GRIK1 (0.61) NPC1RAB9AALDH1A1GAASMN1; SMN2
SCHEMBL3690385 0.83 HPGD (0.77) NPC1RAB9AALDH1A1SMN1; SMN2TP53
SCHEMBL331600 0.82 NPC1 (0.69) NPC1RAB9AALDH1A1GAASMN1; SMN2
Naptalam SCHEMBL8537412 0.82 HSD17B10 (0.74) NPC1RAB9AALDH1A1GAASMN1; SMN2
Naptalam SCHEMBL29469565 0.82 HSD17B10 (0.74) NPC1RAB9AALDH1A1GAASMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023168484-A1 \"COMPOUNDS AND METHODS\ DemAgtech Pty Ltd (AU) 2023-09-14 WO disclosed
WO-2023092188-A1 \"COMPOUNDS AND METHODS\ DemAgtech Pty Ltd (AU) 2023-06-01 WO disclosed
WO-2022051804-A1 COMPOUNDS AND METHODS THE UNIVERSITY OF WESTERN AUSTRALIA (AU) 2022-03-17 WO disclosed
US-8647528-B2 Water absorbing agent and production method thereof NIPPON SHOKUBAI CO., LTD. (JP) 2014-02-11 US disclosed
US-20100270501-A1 Water absorbing agent and production method thereof NIPPON SHOKUBAI CO., LTD. (JP) 2010-10-28 US disclosed