Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | GNRHR | P30968 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | CASP1 | P29466 | 1/20 | 0.34 |
| ▸ | CASP7 | P55210 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | BACE1 | P56817 | 1/20 | 0.34 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.34 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3220801 | 0.77 | PLG (0.45) | ALDH1A1CYP3A4TSHRGNRHRSMN1; SMN2 | |
| SCHEMBL2205126 | 0.77 | PLG (0.45) | ALDH1A1CYP3A4TSHRGNRHRSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL3940414 | 0.76 | PLG (0.44) | ALDH1A1CYP3A4TSHRGNRHRSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL483255 | 0.76 | PLG (0.44) | ALDH1A1CYP3A4TSHRGNRHRSMN1; SMN2 | |
| SCHEMBL23854822 | 0.73 | PTGS1 (0.33) | KMT2A | |
| SCHEMBL20027283 | 0.73 | EPHX1 (0.43) | ALDH1A1SMN1; SMN2KDM4EGLAGAA | |
| SCHEMBL21658591 | 0.73 | EPHX1 (0.43) | ALDH1A1SMN1; SMN2KDM4EGLAGAA | |
| SCHEMBL13551016 | 0.73 | EPHX1 (0.43) | ALDH1A1SMN1; SMN2KDM4EGLAGAA | |
| SCHEMBL462922 | 0.72 | CYP2C19 (0.46) | ALDH1A1SMN1; SMN2KMT2AHPGDNPSR1 | |
| SCHEMBL7262379 | 0.72 | CETP (0.38) | ALDH1A1TSHRCYP2C9BACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8410045-B2 | Camptothecin-peptide conjugates and pharmaceutical compositions containing the same | DRAIS PHARMACEUTICALS, INC. (US) | 2013-04-02 | — | — | US | claimed |
| US-20100015136-A1 | CAMPTOTHECIN-PEPTIDE CONJUGATES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME | DIATOS, S.A. (FR) | 2010-01-21 | — | — | US | claimed |
| EP-1998809-A2 | CAMPTOTHECIN-CELL PENETRATING PEPTIDE CONJUGATES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME | Diatos S.A. (FR) | 2008-12-10 | — | — | EP | claimed |
| WO-2007113687-A2 | CAMPTOTHECIN-CELL PENETRATING PEPTIDE CONJUGATES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME | DIATOS S.A. (FR) | 2007-10-11 | — | — | WO | claimed |
| CN-116406301-A | SN38 peptide conjugates useful in the treatment of cancer | 生物医药研究基金会机构(IRB巴塞罗那) | 2023-07-07 | — | — | CN | disclosed |
| EP-2515944-B1 | METHODS AND COMPOSITIONS RELATED TO ANNEXIN 1-BINDING COMPOUNDS | SANFORD BURNHAM MED RES INST (US) | 2020-04-22 | — | — | EP | disclosed |
| US-20170326245-A1 | Methods and Compositions Related To Annexin 1-Binding Compounds | SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE | 2017-11-16 | — | — | US | disclosed |
| US-9610359-B2 | Methods and compositions related to annexin 1-binding compounds | BURNHAM INSTITUTE FOR MEDICAL RESEARCH (US) | 2017-04-04 | — | — | US | disclosed |
| EP-1998809-B1 | CAMPTOTHECIN-CELL PENETRATING PEPTIDE CONJUGATES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME | DRAIS PHARMACEUTICALS INC (US) | 2014-06-25 | — | — | EP | disclosed |
| US-20130244956-A1 | CAMPTOTHEAN-PEPTIDE CONJUGATES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME | DRAIS PHARMACEUTICALS, INC. (US) | 2013-09-19 | — | — | US | disclosed |
| US-8410045-B2 | Camptothecin-peptide conjugates and pharmaceutical compositions containing the same | DRAIS PHARMACEUTICALS, INC. (US) | 2013-04-02 | — | — | US | disclosed |
| US-20120251453-A1 | Methods and Compositions Related to Annexin 1-Binding Compounds | SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE | 2012-10-04 | — | — | US | disclosed |
| US-20100015136-A1 | CAMPTOTHECIN-PEPTIDE CONJUGATES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME | DIATOS, S.A. (FR) | 2010-01-21 | — | — | US | disclosed |
| EP-1998809-A2 | CAMPTOTHECIN-CELL PENETRATING PEPTIDE CONJUGATES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME | Diatos S.A. (FR) | 2008-12-10 | — | — | EP | disclosed |
| WO-2007113687-A2 | CAMPTOTHECIN-CELL PENETRATING PEPTIDE CONJUGATES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME | DIATOS S.A. (FR) | 2007-10-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100015136-A1 | CAMPTOTHECIN-PEPTIDE CONJUGATES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME | VIP, SLC19A1, CXCL12 | ALDH1A1 3468/4885CYP3A4 3174/4885TSHR 3084/4885 |
| US-20130244956-A1 | CAMPTOTHEAN-PEPTIDE CONJUGATES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME | VIP, PTMS, FURIN | ALDH1A1 3487/4885CYP3A4 2971/4885TSHR 2310/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.