Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 9/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.64 |
| ▸ | MITF | O75030 | 3/20 | 0.52 |
| ▸ | MAPT | P10636 | 6/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.50 |
| ▸ | TP53 | P04637 | 3/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.50 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | XBP1 | P17861 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL368126 | 1.00 | LMNA (0.64) | LMNAALDH1A1MITFMAPTSMN1; SMN2 | |
| SCHEMBL12609083 | 0.81 | LMNA (0.67) | LMNAALDH1A1MITFMAPTSMN1; SMN2 | |
| Nifurtimox SCHEMBL60840 | 0.78 | LMNA (1.00) | LMNAALDH1A1MITFMAPTSMN1; SMN2 | |
| Nifurtimox SCHEMBL60839 | 0.78 | LMNA (1.00) | LMNAALDH1A1MITFMAPTSMN1; SMN2 | |
| Nifurtimox SCHEMBL1650162 | 0.78 | LMNA (1.00) | LMNAALDH1A1MITFMAPTSMN1; SMN2 | |
| Nifurtimox SCHEMBL9910611 | 0.78 | LMNA (1.00) | LMNAALDH1A1MITFMAPTSMN1; SMN2 | |
| SCHEMBL23003603 | 0.77 | LMNA (0.78) | LMNAALDH1A1MITFMAPTSMN1; SMN2 | |
| SCHEMBL23003602 | 0.77 | LMNA (0.78) | LMNAALDH1A1MITFMAPTSMN1; SMN2 | |
| Nifurtimox SCHEMBL4727154 | 0.72 | LMNA (0.85) | LMNAALDH1A1MITFMAPTSMN1; SMN2 | |
| Nifurtimox SCHEMBL2326415 | 0.71 | LMNA (0.83) | LMNAALDH1A1MITFMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2593796-A2 | BACTERIAL NITROREDUCTASE ENZYMES AND METHODS RELATING THERETO | Auckland Uniservices Limited (NZ) | 2013-05-22 | — | — | EP | disclosed |
| WO-2012008860-A2 | BACTERIAL NITROREDUCTASE ENZYMES AND METHODS RELATING THERETO | AUCKLAND UNISERVICES LIMITED (NZ) | 2012-01-19 | — | — | WO | disclosed |
| EP-2392577-A1 | NEW FAMILY OF ANTICHAGASICS DERIVED FROM IMIDAZO[4,5-C][1,2,6]THIADIAZINE 2,2-DIOXIDE | Consejo Superior de Investigaciones Científicas (CSIC) (ES) | 2011-12-07 | — | — | EP | disclosed |
| EP-1903873-A2 | HERPES VIRUS-BASED COMPOSITIONS AND METHODS OF USE IN THE PRENATAL AND PERINATAL PERIODS | THE UNIVERSITY OF ROCHESTER (US) | 2008-04-02 | — | — | EP | disclosed |
| WO-2006135602-A2 | HERPES VIRUS-BASED COMPOSITIONS AND METHODS OF USE IN THE PRENATAL AND PERINATAL PERIODS | UNIVERSITY OF ROCHESTER (US) | 2006-12-21 | — | — | WO | disclosed |