Sugi Predict

Sugi Predict / Compounds / Nifurtimox

Nifurtimox

Nifurtimox

SCHEMBL4727154

CC1CS(=O)(=O)CCN1N=Cc1ccc([N+](=O)[O-])o1.O=[N+]([O-])c1ccco1

nearest known ligand 0.85

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ LMNA P02545 8/20 0.85
▸ ALDH1A1 P00352 6/20 0.85
▸ MAPT P10636 7/20 0.45
▸ SMN1; SMN2 Q16637 4/20 0.45
▸ TP53 P04637 3/20 0.45
▸ CYP1A2 P05177 3/20 0.45
▸ HIF1A Q16665 2/20 0.45
▸ CYP2D6 P10635 1/20 0.45
▸ ALOX15 P16050 1/20 0.45
▸ ATM Q13315 1/20 0.45
▸ MITF O75030 3/20 0.45
▸ TDP1 Q9NUW8 6/20 0.41
▸ MDM2 Q00987 2/20 0.41
▸ KDM4E B2RXH2 2/20 0.41
▸ CYP3A4 P08684 2/20 0.41
▸ ABCC4 O15439 1/20 0.41
▸ TSHR P16473 1/20 0.41
▸ MAOA P21397 1/20 0.41
▸ CASP7 P55210 1/20 0.41
▸ CISD1 Q9NZ45 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Nifurtimox SCHEMBL1650162 0.92 LMNA (1.00) LMNAALDH1A1MAPTSMN1; SMN2TP53
Nifurtimox SCHEMBL9910611 0.92 LMNA (1.00) LMNAALDH1A1MAPTSMN1; SMN2TP53
Nifurtimox SCHEMBL60839 0.92 LMNA (1.00) LMNAALDH1A1MAPTSMN1; SMN2TP53
Nifurtimox SCHEMBL60840 0.92 LMNA (1.00) LMNAALDH1A1MAPTSMN1; SMN2TP53
Nifurtimox SCHEMBL2326415 0.84 LMNA (0.83) LMNAALDH1A1MAPTSMN1; SMN2TP53
SCHEMBL23003603 0.81 LMNA (0.78) LMNAALDH1A1MAPTSMN1; SMN2TP53
SCHEMBL23003602 0.81 LMNA (0.78) LMNAALDH1A1MAPTSMN1; SMN2TP53
Nifurtimox SCHEMBL2326559 0.77 LMNA (0.70) LMNAALDH1A1MAPTSMN1; SMN2TP53
SCHEMBL12609083 0.74 LMNA (0.67) LMNAALDH1A1MAPTSMN1; SMN2TP53
Nifurtimox SCHEMBL28086189 0.73 LMNA (0.60) LMNAALDH1A1MAPTSMN1; SMN2TP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11566012-B2 Methods for treating protozoan infections NEOCULI PTY LTD (AU) 2023-01-31 — — US disclosed
EP-3188722-B1 METHODS FOR TREATING PROTOZOAN INFECTIONS NEOCULI PTY LTD (AU) 2021-08-04 — — EP disclosed
US-20210009552-A1 METHODS FOR TREATING PROTOZOAN INFECTIONS NEOCULI PTY LTD (AU) 2021-01-14 — — US disclosed
US-10829468-B2 Methods for treating protozoan infections NEOCULI PTY LTD. (AU) 2020-11-10 — — US disclosed
US-20200290990-A1 METHODS FOR TREATING PROTOZOAN INFECTIONS NEOCULI PTY LTD (AU) 2020-09-17 — — US disclosed
US-10752606-B2 Methods for treating protozoan infections NEOCULI PTY LTD. (AU) 2020-08-25 — — US disclosed
US-20200102287-A1 METHODS FOR TREATING PROTOZOAN INFECTIONS NEOCULI PTY LTD (AU) 2020-04-02 — — US disclosed
US-10562880-B2 Methods for treating protozoan infections NEOCULI PTY LTD. (AU) 2020-02-18 — — US disclosed
US-20190330178-A1 METHODS FOR TREATING PROTOZOAN INFECTIONS NEOCULI PTY LTD (AU) 2019-10-31 — — US disclosed
US-10392363-B2 Methods for treating protozoan infections NEOCULI PTY LTD. (AU) 2019-08-27 — — US disclosed
US-20170291886-A1 METHODS FOR TREATING PROTOZOAN INFECTIONS NEOCULI PTY LTD (AU) 2017-10-12 — — US disclosed
CN-107106524-A Methods for treating protozoal infections 尼奥酷里私人有限公司 2017-08-29 — — CN disclosed
EP-3188722-A1 METHODS FOR TREATING PROTOZOAN INFECTIONS Neoculi Pty Ltd (AU) 2017-07-12 — — EP disclosed
WO-2016033635-A1 METHODS FOR TREATING PROTOZOAN INFECTIONS NEOCULI PTY LTD (AU) 2016-03-10 — — WO disclosed
WO-2008022422-A1 PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF TRIPANOSSOMIASIS AND CHAGAS DISEASE FUNDAÇÃO UNIVERSIDADE DE BRASÍLIA (BR) 2008-02-28 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11566012-B2 Methods for treating protozoan infections DPM1, ABCB11, PIGS LMNA 2337/4885ALDH1A1 840/4885MAPT 3694/4885
US-20200290990-A1 METHODS FOR TREATING PROTOZOAN INFECTIONS DPM1, ABCB11, PIGS LMNA 2337/4885ALDH1A1 840/4885MAPT 3694/4885
US-20210009552-A1 METHODS FOR TREATING PROTOZOAN INFECTIONS DPM1, ABCB11, PIGS LMNA 2337/4885ALDH1A1 840/4885MAPT 3694/4885
US-20170291886-A1 METHODS FOR TREATING PROTOZOAN INFECTIONS DPM1, ABCB11, PIGS LMNA 2337/4885ALDH1A1 840/4885MAPT 3694/4885
US-20200102287-A1 METHODS FOR TREATING PROTOZOAN INFECTIONS DPM1, ABCB11, PIGS LMNA 2337/4885ALDH1A1 840/4885MAPT 3694/4885
US-20190330178-A1 METHODS FOR TREATING PROTOZOAN INFECTIONS DPM1, ABCB11, PIGS LMNA 2337/4885ALDH1A1 840/4885MAPT 3694/4885
US-10829468-B2 Methods for treating protozoan infections DPM1, ABCB11, PIGS LMNA 2337/4885ALDH1A1 840/4885MAPT 3694/4885
US-10562880-B2 Methods for treating protozoan infections DPM1, ABCB11, PIGS LMNA 2337/4885ALDH1A1 840/4885MAPT 3694/4885
US-10752606-B2 Methods for treating protozoan infections DPM1, ABCB11, PIGS LMNA 2337/4885ALDH1A1 840/4885MAPT 3694/4885
US-10392363-B2 Methods for treating protozoan infections DPM1, ABCB11, PIGS LMNA 2337/4885ALDH1A1 840/4885MAPT 3694/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.