Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 8/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 1.00 |
| ▸ | MAPT | P10636 | 7/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.52 |
| ▸ | TP53 | P04637 | 3/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.52 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.52 |
| ▸ | ATM | Q13315 | 1/20 | 0.52 |
| ▸ | MITF | O75030 | 3/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | XBP1 | P17861 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Nifurtimox SCHEMBL1650162 | 1.00 | LMNA (1.00) | LMNAALDH1A1MAPTSMN1; SMN2TP53 | |
| Nifurtimox SCHEMBL60839 | 1.00 | LMNA (1.00) | LMNAALDH1A1MAPTSMN1; SMN2TP53 | |
| Nifurtimox SCHEMBL60840 | 1.00 | LMNA (1.00) | LMNAALDH1A1MAPTSMN1; SMN2TP53 | |
| Nifurtimox SCHEMBL4727154 | 0.92 | LMNA (0.85) | LMNAALDH1A1MAPTSMN1; SMN2TP53 | |
| Nifurtimox SCHEMBL2326415 | 0.91 | LMNA (0.83) | LMNAALDH1A1MAPTSMN1; SMN2TP53 | |
| SCHEMBL23003602 | 0.88 | LMNA (0.78) | LMNAALDH1A1MAPTSMN1; SMN2TP53 | |
| SCHEMBL23003603 | 0.88 | LMNA (0.78) | LMNAALDH1A1MAPTSMN1; SMN2TP53 | |
| Nifurtimox SCHEMBL2326559 | 0.84 | LMNA (0.70) | LMNAALDH1A1MAPTSMN1; SMN2TP53 | |
| SCHEMBL12609083 | 0.80 | LMNA (0.67) | LMNAALDH1A1MAPTSMN1; SMN2TP53 | |
| SCHEMBL368127 | 0.78 | LMNA (0.64) | LMNAALDH1A1MAPTSMN1; SMN2TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2114410-B1 | N-AMINO TETRAHYDROTHIAZINE DERIVATIVES, METHOD OF MANUFACTURE AND USE | WOMEN & INFANTS HOSPITAL (US) | 2015-03-25 | — | — | EP | disclosed |
| US-8193180-B2 | N-amino tetrahydrothiazine derivatives, method of manufacture and use | WOMEN & INFANTS HOSPITAL (US) | 2012-06-05 | — | — | US | disclosed |
| US-8193180-B2 | N-amino tetrahydrothiazine derivatives, method of manufacture and use | WOMEN & INFANTS HOSPITAL (US) | 2012-06-05 | — | — | US | disclosed |
| US-20100179136-A1 | N-AMINO TETRAHYDROTHIAZINE DERIVATIVES, METHOD OF MANUFACTURE AND USE | WOMEN & INFANTS HOSPITAL (US) | 2010-07-15 | — | — | US | disclosed |
| US-20100179136-A1 | N-AMINO TETRAHYDROTHIAZINE DERIVATIVES, METHOD OF MANUFACTURE AND USE | WOMEN & INFANTS HOSPITAL (US) | 2010-07-15 | — | — | US | disclosed |
| WO-2008091946-A2 | N-AMINO TETRAHYDROTHIAZINE DERIVATIVES, METHOD OF MANUFACTURE AND USE | WOMEN & INFANTS HOSPITAL (US) | 2008-07-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100179136-A1 | N-AMINO TETRAHYDROTHIAZINE DERIVATIVES, METHOD OF MANUFACTURE AND USE | NNMT, GNMT, BHMT2 | LMNA 4352/4885ALDH1A1 1748/4885MAPT 1344/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.