Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RELA | Q04206 | 4/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 6/20 | 0.42 |
| ▸ | MAPT | P10636 | 5/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | ATM | Q13315 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.39 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3694295 | 0.90 | MAPT (0.53) | RELAPTPN1MAPTALDH1A1LMNA | |
| SCHEMBL3691644 | 0.87 | CYP1B1 (0.46) | PTPN1MAPTALOX5SMN1; SMN2RAB9A | |
| SCHEMBL3687211 | 0.84 | LMNA (0.46) | RELAPTPN1MAPTALDH1A1LMNA | |
| SCHEMBL3686656 | 0.81 | ALDH1A1 (0.52) | MAPTALDH1A1LMNASMN1; SMN2RAB9A | |
| SCHEMBL3685597 | 0.81 | ABCG2 (0.51) | PTPN1MAPTALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL3687869 | 0.80 | BCHE (0.54) | MAPTALDH1A1LMNASMN1; SMN2ATM | |
| SCHEMBL3685871 | 0.80 | PTPN1 (0.45) | RELAPTPN1MAPTALDH1A1LMNA | |
| SCHEMBL3686241 | 0.80 | PTPN1 (0.45) | RELAPTPN1MAPTALDH1A1LMNA | |
| SCHEMBL3688870 | 0.79 | MAOB (0.53) | RELAMAPTALDH1A1LMNAATM | |
| SCHEMBL3683356 | 0.79 | MAOB (0.45) | MAPTALDH1A1SMN1; SMN2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060235073-A1 | Diamino-functional chalcones | LICA PHARMACEUTICALS A/S (DK) | 2006-10-19 | — | — | US | claimed |
| US-7642367-B2 | Diamino-functional chalcones | LICA PHARMACEUTICALS A/S (DK) | 2010-01-05 | — | — | US | disclosed |
| US-20060235073-A1 | Diamino-functional chalcones | LICA PHARMACEUTICALS A/S (DK) | 2006-10-19 | — | — | US | disclosed |