Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCG2 | Q9UNQ0 | 4/20 | 0.51 |
| ▸ | MAPT | P10636 | 5/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | MAOB | P27338 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.46 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.43 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3686656 | 0.89 | ALDH1A1 (0.52) | MAPTKMT2AMEN1ALDH1A1LMNA | |
| SCHEMBL3694295 | 0.86 | MAPT (0.53) | MAPTALDH1A1LMNAMAOBPTPN1 | |
| SCHEMBL3685871 | 0.85 | PTPN1 (0.45) | MAPTKMT2AMEN1ALDH1A1LMNA | |
| SCHEMBL3686241 | 0.85 | PTPN1 (0.45) | MAPTKMT2AMEN1ALDH1A1LMNA | |
| SCHEMBL3687869 | 0.83 | BCHE (0.54) | MAPTKMT2AMEN1ALDH1A1LMNA | |
| SCHEMBL3688870 | 0.82 | MAOB (0.53) | ABCG2MAPTKMT2AMEN1ALDH1A1 | |
| SCHEMBL3683359 | 0.81 | RELA (0.44) | MAPTKMT2AMEN1ALDH1A1LMNA | |
| SCHEMBL3696162 | 0.79 | BCHE (0.56) | ABCG2MAPTKMT2AMEN1ALDH1A1 | |
| SCHEMBL3691580 | 0.79 | BCHE (0.56) | ABCG2MAPTKMT2AMEN1ALDH1A1 | |
| SCHEMBL3690207 | 0.78 | BCHE (0.54) | MAPTKMT2ALMNAMAOBSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060235073-A1 | Diamino-functional chalcones | LICA PHARMACEUTICALS A/S (DK) | 2006-10-19 | — | — | US | claimed |
| US-7642367-B2 | Diamino-functional chalcones | LICA PHARMACEUTICALS A/S (DK) | 2010-01-05 | — | — | US | disclosed |
| US-20060235073-A1 | Diamino-functional chalcones | LICA PHARMACEUTICALS A/S (DK) | 2006-10-19 | — | — | US | disclosed |