Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 17/20 | 0.80 |
| ▸ | AKR1B10 | O60218 | 2/20 | 0.80 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.80 |
| ▸ | MMP2 | P08253 | 1/20 | 0.80 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.80 |
| ▸ | AKR1C2 | P52895 | 15/20 | 0.59 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.50 |
| ▸ | PTGES | O14684 | 1/20 | 0.50 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.50 |
| ▸ | STAT3 | P40763 | 1/20 | 0.50 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.50 |
| ▸ | RELA | Q04206 | 1/20 | 0.50 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.50 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3684668 | 1.00 | AKR1C3 (0.80) | AKR1C3AKR1B10AKR1B1MMP2PAK1 | |
| Artepillin SCHEMBL7128580 | 0.89 | AKR1C3 (1.00) | AKR1C3AKR1B10AKR1B1MMP2PAK1 | |
| Artepillin SCHEMBL2138507 | 0.89 | AKR1C3 (1.00) | AKR1C3AKR1B10AKR1B1MMP2PAK1 | |
| Artepillin SCHEMBL1229229 | 0.89 | AKR1C3 (1.00) | AKR1C3AKR1B10AKR1B1MMP2PAK1 | |
| SCHEMBL25890163 | 0.85 | AKR1C3 (0.91) | AKR1C3AKR1B10AKR1B1MMP2PAK1 | |
| SCHEMBL26422962 | 0.85 | AKR1C3 (0.91) | AKR1C3AKR1B10AKR1B1MMP2PAK1 | |
| SCHEMBL8467360 | 0.82 | AKR1C3 (0.86) | AKR1C3AKR1B10AKR1B1MMP2PAK1 | |
| SCHEMBL8467358 | 0.82 | AKR1C3 (0.86) | AKR1C3AKR1B10AKR1B1MMP2PAK1 | |
| SCHEMBL23742688 | 0.81 | AKR1C3 (0.84) | AKR1C3AKR1B10AKR1B1MMP2PAK1 | |
| SCHEMBL29574915 | 0.81 | AKR1C3 (0.84) | AKR1C3AKR1B10AKR1B1MMP2PAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8367121-B2 | Nutraceutical agent for attenuating the neurodegenerative process associated with Parkinson's disease | FLORIDA A & M UNIVERSITY (US) | 2013-02-05 | — | — | US | disclosed |
| US-20100150895-A1 | Nutraceutical agent for attenuating the Neurodegenerative process associated with Parkinson's disease | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2010-06-17 | — | — | US | disclosed |
| US-20080292607-A1 | Nutraceutical agent for attenuating the neurodegenerative process associated with Parkinson's disease | MAZZIO ELIZABETH | 2008-11-27 | — | — | US | disclosed |
| US-20070116779-A1 | Comprehensive nutraceutical agent for treatment/ prevention of Parkinson's disease | MAZZIO ELIZABETH | 2007-05-24 | — | — | US | disclosed |