SCHEMBL3685174

SCHEMBL3685174

COc1cccc(CNC(=O)c2ccnc(C)n2)c1

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MMP13 P45452 2/20 0.60
ROCK1 Q13464 3/20 0.57
PRKACA P17612 2/20 0.57
PRKX P51817 2/20 0.57
PRKCQ Q04759 2/20 0.57
ROCK2 O75116 2/20 0.57
CYP3A4 P08684 1/20 0.57
CYP2D6 P10635 1/20 0.57
CYP2C9 P11712 1/20 0.57
GSK3A P49840 1/20 0.57
GSK3B P49841 1/20 0.57
CLK4 Q9HAZ1 1/20 0.57
HPGD P15428 3/20 0.56
KMT2A Q03164 1/20 0.56
GRK5 P34947 1/20 0.56
KDM4E B2RXH2 2/20 0.55
HSD17B10 Q99714 1/20 0.55
ADORA3 P0DMS8 1/20 0.55
ADORA2A P29274 1/20 0.55
ADORA2B P29275 1/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8055231 0.82 MMP13 (0.58) MMP13ROCK1PRKACAPRKXPRKCQ
SCHEMBL5252907 0.82 ROCK2 (0.64) MMP13ROCK1PRKACAPRKXPRKCQ
SCHEMBL5209384 0.82 MMP13 (0.72) MMP13ROCK1PRKACAPRKXPRKCQ
SCHEMBL8358822 0.81 MMP13 (0.69) MMP13ROCK1PRKACAPRKXPRKCQ
SCHEMBL7010262 0.81 KMT2A (0.59) MMP13ROCK1PRKACAPRKXPRKCQ
SCHEMBL7010267 0.81 LMNA (0.61) MMP13ROCK1PRKACAPRKXPRKCQ
SCHEMBL8067349 0.80 MMP13 (0.55) MMP13ROCK1PRKACAPRKXPRKCQ
SCHEMBL3694194 0.79 MMP13 (0.51) MMP13ROCK1ROCK2KMT2AALDH1A1
SCHEMBL8348366 0.78 MMP13 (0.61) MMP13ROCK1PRKACAPRKXPRKCQ
SCHEMBL5096069 0.78 ROCK2 (0.59) MMP13ROCK1PRKACAPRKXPRKCQ

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2704712-A1 ISOXAZOLINES AS THERAPEUTIC AGENTS AbbVie Inc. (US) 2014-03-12 EP disclosed
WO-2012151158-A1 ISOXAZOLINES AS THERAPEUTIC AGENTS ABBOTT LABORATORIES (US) 2012-11-08 WO disclosed
EP-2185537-A1 PYRIMIDINE AND PYRIDINE DERIVATIVES AND THEIR PHARMACEUTICAL USE AND COMPOSITIONS Pfizer Inc. (US) 2010-05-19 EP disclosed
WO-2009016498-A1 PYRIMIDINE AND PYRIDINE DERIVATIVES AND THEIR PHARMACEUTICAL USE AND COMPOSITIONS PFIZER INC. (US) 2009-02-05 WO disclosed