SCHEMBL3685240

SCHEMBL3685240

CN1CCN(c2ccc(-c3ccccc3)c(C=CC(=O)c3ccc(O)cc3)c2)CC1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CTSL P07711 1/20 0.53
CTSB P07858 1/20 0.53
HDAC3 O15379 7/20 0.50
HDAC4 P56524 7/20 0.50
HDAC1 Q13547 7/20 0.50
HDAC7 Q8WUI4 7/20 0.50
HDAC2 Q92769 7/20 0.50
HDAC10 Q969S8 7/20 0.50
HDAC11 Q96DB2 7/20 0.50
HDAC8 Q9BY41 7/20 0.50
HDAC6 Q9UBN7 7/20 0.50
HDAC9 Q9UKV0 7/20 0.50
HDAC5 Q9UQL6 7/20 0.50
BACE1 P56817 1/20 0.45
PTPN1 P18031 1/20 0.45
MAOB P27338 3/20 0.44
ESR1 P03372 2/20 0.43
ESRRG P62508 2/20 0.43
MAPT P10636 4/20 0.43
MEN1 O00255 2/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3684483 0.81 HDAC3 (0.49) HDAC3HDAC4HDAC1HDAC7HDAC2
SCHEMBL3685239 0.81 HDAC3 (0.53) CTSLCTSBHDAC3HDAC4HDAC1
SCHEMBL3687425 0.81 HDAC3 (0.53) CTSLCTSBHDAC3HDAC4HDAC1
SCHEMBL3686624 0.80 PTPN1 (0.44) HDAC3HDAC4HDAC1HDAC7HDAC2
SCHEMBL3696557 0.77 HDAC3 (0.47) HDAC3HDAC4HDAC1HDAC7HDAC2
SCHEMBL21802490 0.77 HDAC3 (0.79) CTSLCTSBHDAC3HDAC4HDAC1
SCHEMBL3687696 0.77 MEN1 (0.45) HDAC3HDAC1HDAC8MAOBMAPT
SCHEMBL3685781 0.76 ADORA2A (0.51) MEN1KMT2ANPC1RAB9A
SCHEMBL3688376 0.74 LMNA (0.42) CTSLCTSBHDAC3HDAC4HDAC1
SCHEMBL3688449 0.73 MAOB (0.55) CTSLCTSBPTPN1MAOBMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20060235073-A1 Diamino-functional chalcones LICA PHARMACEUTICALS A/S (DK) 2006-10-19 US claimed
EP-1506158-A2 DIAMINO-FUNCTIONAL CHALCONES Lica Pharmaceuticals A/S (DK) 2005-02-16 EP claimed
WO-2003097576-A2 DIAMINO-FUNCTIONAL CHALCONES LICA PHARMACEUTICALS A/S (DK) 2003-11-27 WO claimed
US-7642367-B2 Diamino-functional chalcones LICA PHARMACEUTICALS A/S (DK) 2010-01-05 US disclosed
US-20060235073-A1 Diamino-functional chalcones LICA PHARMACEUTICALS A/S (DK) 2006-10-19 US disclosed
EP-1506158-A2 DIAMINO-FUNCTIONAL CHALCONES Lica Pharmaceuticals A/S (DK) 2005-02-16 EP disclosed
WO-2003097576-A2 DIAMINO-FUNCTIONAL CHALCONES LICA PHARMACEUTICALS A/S (DK) 2003-11-27 WO disclosed