Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CAPN1 | P07384 | 3/20 | 0.47 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.46 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.44 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.44 |
| ▸ | PDE4A | P27815 | 1/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.43 |
| ▸ | BACE1 | P56817 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | MAOB | P27338 | 2/20 | 0.42 |
| ▸ | PARP1 | P09874 | 1/20 | 0.42 |
| ▸ | MAOA | P21397 | 1/20 | 0.42 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.41 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3686266 | 0.90 | PDE4A (0.43) | PTPN1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL3685946 | 0.89 | CHRNA7 (0.44) | CAPN1NR1H4PTPN1CHRNA7BACE1 | |
| SCHEMBL3692417 | 0.89 | CHRNA7 (0.44) | CAPN1NR1H4PTPN1CHRNA7BACE1 | |
| SCHEMBL3687530 | 0.88 | PTPN1 (0.55) | PTPN1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL3683957 | 0.85 | CHRNA7 (0.40) | CAPN1NR1H4PTPN1CHRNA7ALDH1A1 | |
| SCHEMBL3693475 | 0.80 | SMN1; SMN2 (0.46) | PTPN1PDE4BALDH1A1SMN1; SMN2MAOB | |
| SCHEMBL3687529 | 0.80 | SMN1; SMN2 (0.46) | PTPN1PDE4BALDH1A1SMN1; SMN2MAOB | |
| SCHEMBL3687761 | 0.79 | HTR1A (0.44) | PTPN1ALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL3686263 | 0.79 | HTR1A (0.43) | PTPN1ALDH1A1SMN1; SMN2MEN1MAPT | |
| SCHEMBL3692486 | 0.79 | HTR1A (0.43) | PTPN1ALDH1A1SMN1; SMN2MEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060235073-A1 | Diamino-functional chalcones | LICA PHARMACEUTICALS A/S (DK) | 2006-10-19 | — | — | US | claimed |
| US-7642367-B2 | Diamino-functional chalcones | LICA PHARMACEUTICALS A/S (DK) | 2010-01-05 | — | — | US | disclosed |
| US-20060235073-A1 | Diamino-functional chalcones | LICA PHARMACEUTICALS A/S (DK) | 2006-10-19 | — | — | US | disclosed |