Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 3/20 | 0.44 |
| ▸ | HTR1D | P28221 | 2/20 | 0.44 |
| ▸ | HTR1B | P28222 | 2/20 | 0.44 |
| ▸ | HTR6 | P50406 | 2/20 | 0.44 |
| ▸ | HTR2C | P28335 | 1/20 | 0.44 |
| ▸ | KRAS | P01116 | 1/20 | 0.43 |
| ▸ | TNFRSF1A | P19438 | 2/20 | 0.43 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.42 |
| ▸ | ERAP1 | Q9NZ08 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | HTR7 | P34969 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3687530 | 0.85 | PTPN1 (0.55) | HTR1AHTR1DHTR1BHTR6HTR2C | |
| SCHEMBL3692364 | 0.81 | HTR1A (0.44) | HTR1AHTR1DHTR1BHTR6HTR2C | |
| SCHEMBL3687759 | 0.81 | HTR1A (0.44) | HTR1AHTR1DHTR1BHTR6HTR2C | |
| SCHEMBL3685949 | 0.79 | CAPN1 (0.47) | ABCB1SMN1; SMN2ALDH1A1PTPN1MEN1 | |
| SCHEMBL3686266 | 0.79 | PDE4A (0.43) | HTR1AHTR1DHTR1BHTR6HTR2C | |
| SCHEMBL3687529 | 0.79 | SMN1; SMN2 (0.46) | HTR1AHTR1DHTR1BHTR6HTR2C | |
| SCHEMBL3693475 | 0.79 | SMN1; SMN2 (0.46) | HTR1AHTR1DHTR1BHTR6HTR2C | |
| SCHEMBL3688318 | 0.79 | NPY2R (0.46) | HTR1AHTR1DHTR1BHTR6HTR2C | |
| SCHEMBL3686111 | 0.75 | KRAS (0.47) | HTR1AHTR1DHTR1BHTR6HTR2C | |
| SCHEMBL3691974 | 0.75 | RAB9A (0.51) | SMN1; SMN2ALDH1A1LMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060235073-A1 | Diamino-functional chalcones | LICA PHARMACEUTICALS A/S (DK) | 2006-10-19 | — | — | US | claimed |
| US-7642367-B2 | Diamino-functional chalcones | LICA PHARMACEUTICALS A/S (DK) | 2010-01-05 | — | — | US | disclosed |
| US-20060235073-A1 | Diamino-functional chalcones | LICA PHARMACEUTICALS A/S (DK) | 2006-10-19 | — | — | US | disclosed |