Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | FAAH | O00519 | 2/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.41 |
| ▸ | NAMPT | P43490 | 1/20 | 0.40 |
| ▸ | MMP13 | P45452 | 1/20 | 0.40 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.40 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.40 |
| ▸ | SDCBP | O00560 | 1/20 | 0.39 |
| ▸ | SDC2 | P34741 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28710981 | 0.89 | L3MBTL1 (0.46) | GRM2L3MBTL1GAAFAAHHDAC1 | |
| SCHEMBL10165058 | 0.85 | ALDH1A1 (0.51) | GRM2 | |
| SCHEMBL21090329 | 0.83 | GRM2 (0.49) | GRM2L3MBTL1GAAHDAC1NAMPT | |
| SCHEMBL3646064 | 0.82 | MMP13 (0.45) | MMP13CYP4F2CYP4A11 | |
| SCHEMBL24999627 | 0.82 | GRM2 (0.49) | GRM2L3MBTL1GAAHDAC1NAMPT | |
| SCHEMBL29769069 | 0.82 | GRM2 (0.49) | GRM2L3MBTL1GAAHDAC1NAMPT | |
| SCHEMBL8252975 | 0.81 | GRM2 (0.44) | GRM2L3MBTL1GAAHDAC1NAMPT | |
| SCHEMBL28177950 | 0.81 | GRM2 (0.48) | GRM2L3MBTL1GAAFAAHHDAC1 | |
| SCHEMBL23761812 | 0.81 | GRM2 (0.45) | GRM2L3MBTL1GAANAMPT | |
| SCHEMBL30034155 | 0.81 | GRM2 (0.45) | GRM2L3MBTL1GAANAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2185537-A1 | PYRIMIDINE AND PYRIDINE DERIVATIVES AND THEIR PHARMACEUTICAL USE AND COMPOSITIONS | Pfizer Inc. (US) | 2010-05-19 | — | — | EP | disclosed |
| WO-2009016498-A1 | PYRIMIDINE AND PYRIDINE DERIVATIVES AND THEIR PHARMACEUTICAL USE AND COMPOSITIONS | PFIZER INC. (US) | 2009-02-05 | — | — | WO | disclosed |
| WO-2009016498-A1 | PYRIMIDINE AND PYRIDINE DERIVATIVES AND THEIR PHARMACEUTICAL USE AND COMPOSITIONS | PFIZER INC. (US) | 2009-02-05 | — | — | WO | disclosed |