Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 8/20 | 0.43 |
| ▸ | MTNR1B | P49286 | 8/20 | 0.43 |
| ▸ | TSHR | P16473 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.41 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | PRNP | P04156 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3694137 | 0.79 | MAPT (0.49) | ALDH1A1MAPTKDM4EHPGDKMT2A | |
| SCHEMBL334924 | 0.78 | KDM4E (0.56) | TSHRALDH1A1MAPTKDM4EHPGD | |
| Acetophenone SCHEMBL28328806 | 0.76 | SMN1; SMN2 (0.54) | ALDH1A1MAPTHPGDHTTKMT2A | |
| SCHEMBL3687869 | 0.76 | BCHE (0.54) | ALDH1A1MAPTKMT2AMEN1LMNA | |
| SCHEMBL24011663 | 0.75 | HTT (0.46) | TSHRALDH1A1MAPTKDM4EHPGD | |
| SCHEMBL2894413 | 0.75 | HTT (0.46) | TSHRALDH1A1MAPTKDM4EHPGD | |
| SCHEMBL29591101 | 0.75 | ALDH1A1 (0.59) | MTNR1AMTNR1BTSHRALDH1A1HSD17B10 | |
| SCHEMBL2388543 | 0.75 | ALDH1A1 (0.59) | MTNR1AMTNR1BTSHRALDH1A1HSD17B10 | |
| SCHEMBL3696162 | 0.74 | BCHE (0.56) | ALDH1A1MAPTKMT2AMEN1PKM | |
| SCHEMBL3691580 | 0.74 | BCHE (0.56) | ALDH1A1MAPTKMT2AMEN1PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7642367-B2 | Diamino-functional chalcones | LICA PHARMACEUTICALS A/S (DK) | 2010-01-05 | — | — | US | disclosed |
| US-20060235073-A1 | Diamino-functional chalcones | LICA PHARMACEUTICALS A/S (DK) | 2006-10-19 | — | — | US | disclosed |
| EP-1506158-A2 | DIAMINO-FUNCTIONAL CHALCONES | Lica Pharmaceuticals A/S (DK) | 2005-02-16 | — | — | EP | disclosed |
| WO-2003097576-A2 | DIAMINO-FUNCTIONAL CHALCONES | LICA PHARMACEUTICALS A/S (DK) | 2003-11-27 | — | — | WO | disclosed |