Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR2 | O43614 | 2/20 | 0.38 |
| ▸ | SYK | P43405 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 9/20 | 0.37 |
| ▸ | LMNA | P02545 | 8/20 | 0.37 |
| ▸ | MEN1 | O00255 | 5/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.37 |
| ▸ | ATM | Q13315 | 5/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | MET | P08581 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.36 |
| ▸ | RECQL | P46063 | 3/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4852888 | 0.85 | HCRTR2 (0.42) | HCRTR2SYKMAPTLMNAMEN1 | |
| SCHEMBL3689620 | 0.82 | SYK (0.39) | HCRTR2SYKMAPTMEN1KMT2A | |
| SCHEMBL3697631 | 0.82 | SYK (0.39) | HCRTR2SYKMAPTMEN1KMT2A | |
| SCHEMBL3686567 | 0.81 | PRKD1 (0.39) | HCRTR2SYKMAPTLMNAMEN1 | |
| SCHEMBL3691488 | 0.81 | HCRTR2 (0.36) | HCRTR2SYKMAPTLMNAMEN1 | |
| SCHEMBL4847749 | 0.74 | ACHE (0.42) | SYKMAPTLMNAMEN1KMT2A | |
| SCHEMBL4846060 | 0.74 | MAPT (0.50) | MAPTLMNAMEN1KMT2AATM | |
| SCHEMBL4846042 | 0.74 | MAPT (0.50) | MAPTLMNAMEN1KMT2AATM | |
| SCHEMBL3692728 | 0.73 | LMNA (0.50) | MAPTLMNAMEN1KMT2ATP53 | |
| SCHEMBL3685658 | 0.72 | ERN1 (0.35) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060235073-A1 | Diamino-functional chalcones | LICA PHARMACEUTICALS A/S (DK) | 2006-10-19 | — | — | US | claimed |
| US-7642367-B2 | Diamino-functional chalcones | LICA PHARMACEUTICALS A/S (DK) | 2010-01-05 | — | — | US | disclosed |
| US-20060235073-A1 | Diamino-functional chalcones | LICA PHARMACEUTICALS A/S (DK) | 2006-10-19 | — | — | US | disclosed |