Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MMP13 | P45452 | 2/20 | 0.41 |
| ▸ | MMP2 | P08253 | 1/20 | 0.41 |
| ▸ | MMP3 | P08254 | 1/20 | 0.41 |
| ▸ | MMP9 | P14780 | 1/20 | 0.41 |
| ▸ | MMP8 | P22894 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | GPR119 | Q8TDV5 | 5/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6586204 | 0.83 | LMNA (0.54) | SMN1; SMN2LMNAPOLBMMP13MMP2 | |
| SCHEMBL15048844 | 0.81 | LMNA (0.51) | SMN1; SMN2LMNAPOLBALDH1A1MMP13 | |
| SCHEMBL724672 | 0.80 | SMN1; SMN2 (0.50) | SMN1; SMN2LMNAPOLBMMP13MMP2 | |
| SCHEMBL31540784 | 0.80 | LMNA (0.50) | SMN1; SMN2LMNAPOLBMMP13MMP2 | |
| SCHEMBL725320 | 0.79 | LMNA (0.58) | SMN1; SMN2LMNAPOLBALDH1A1MMP13 | |
| SCHEMBL11974037 | 0.79 | POLB (0.58) | SMN1; SMN2LMNAPOLBMEN1KMT2A | |
| SCHEMBL16256877 | 0.79 | LMNA (0.58) | SMN1; SMN2LMNAPOLBALDH1A1MMP13 | |
| SCHEMBL21496883 | 0.78 | LMNA (0.40) | SMN1; SMN2LMNAPOLBALDH1A1MMP13 | |
| SCHEMBL7985579 | 0.77 | LMNA (0.56) | SMN1; SMN2LMNAPOLBALDH1A1MMP13 | |
| SCHEMBL30510136 | 0.77 | SMN1; SMN2 (0.56) | SMN1; SMN2LMNAPOLBALDH1A1MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2201002-A1 | 5-HT7 RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2010-06-30 | — | — | EP | disclosed |
| WO-2009048765-A1 | 5-HT7 RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2009-04-16 | — | — | WO | disclosed |