Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | MMP13 | P45452 | 3/20 | 0.38 |
| ▸ | MMP3 | P08254 | 2/20 | 0.38 |
| ▸ | MMP9 | P14780 | 2/20 | 0.38 |
| ▸ | MMP1 | P03956 | 1/20 | 0.38 |
| ▸ | MMP7 | P09237 | 1/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.36 |
| ▸ | MMP2 | P08253 | 1/20 | 0.36 |
| ▸ | MMP8 | P22894 | 1/20 | 0.36 |
| ▸ | F13A1 | P00488 | 1/20 | 0.36 |
| ▸ | TGM2 | P21980 | 1/20 | 0.36 |
| ▸ | TGM1 | P22735 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 3/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21496888 | 0.93 | ALDH1A1 (0.41) | LMNAPOLBSMN1; SMN2MMP13MMP3 | |
| SCHEMBL21511403 | 0.80 | HPGD (0.55) | POLBSMN1; SMN2ALDH1A1HPGDMEN1 | |
| SCHEMBL21513054 | 0.80 | HPGD (0.55) | POLBSMN1; SMN2ALDH1A1HPGDMEN1 | |
| SCHEMBL21512971 | 0.79 | ALDH1A1 (0.39) | LMNAPOLBALDH1A1F10 | |
| SCHEMBL3689756 | 0.78 | SMN1; SMN2 (0.49) | LMNAPOLBSMN1; SMN2MMP13MMP3 | |
| SCHEMBL21496865 | 0.78 | F10 (0.37) | LMNAPOLBALDH1A1F13A1TGM2 | |
| SCHEMBL5724467 | 0.76 | LMNA (0.51) | LMNAPOLBSMN1; SMN2MMP13MMP3 | |
| SCHEMBL9285131 | 0.76 | LMNA (0.51) | LMNAPOLBSMN1; SMN2MMP13MMP3 | |
| SCHEMBL9665931 | 0.75 | SMN1; SMN2 (0.50) | LMNAPOLBSMN1; SMN2MMP13MMP3 | |
| SCHEMBL6119560 | 0.75 | SMN1; SMN2 (0.50) | LMNAPOLBSMN1; SMN2MMP13MMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019204505-A2 | K-RAS MODULATORS WITH A VINYL SULFONAMIDE MOIETY | THERAS, INC. (US) | 2019-10-24 | — | — | WO | disclosed |