Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.57 |
| ▸ | HTT | P42858 | 1/20 | 0.57 |
| ▸ | RECQL | P46063 | 1/20 | 0.57 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.57 |
| ▸ | PRKDC | P78527 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 7/20 | 0.48 |
| ▸ | NPC1 | O15118 | 6/20 | 0.47 |
| ▸ | HTR3A | P46098 | 1/20 | 0.46 |
| ▸ | SIRT6 | Q8N6T7 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3503841 | 0.84 | PRKDC (0.70) | GAAKDM4EMAPTMAPK1HTT | |
| SCHEMBL30590422 | 0.83 | MAPT (0.55) | GAAKDM4EMAPTMAPK1HTT | |
| SCHEMBL3503585 | 0.83 | MAPT (0.55) | GAAKDM4EMAPTMAPK1HTT | |
| SCHEMBL3534452 | 0.81 | ALDH1A1 (0.56) | GAAKDM4EMAPTMAPK1HTT | |
| SCHEMBL9937590 | 0.81 | PRKDC (0.54) | GAAKDM4EMAPTMAPK1HTT | |
| SCHEMBL11021414 | 0.81 | SIRT6 (0.49) | GAAKDM4EMAPTMAPK1HTT | |
| SCHEMBL3688257 | 0.80 | ALDH1A1 (0.51) | KDM4EMAPTMAPK1ALDH1A1RAB9A | |
| Hydrochloric Acid SCHEMBL3539657 | 0.80 | ALDH1A1 (0.55) | GAAKDM4EMAPTMAPK1HTT | |
| SCHEMBL1481913 | 0.79 | RAB9A (0.53) | MAPTMAPK1HTTPRKDCALDH1A1 | |
| SCHEMBL10739901 | 0.79 | MAPT (0.59) | GAAKDM4EMAPTMAPK1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7642367-B2 | Diamino-functional chalcones | LICA PHARMACEUTICALS A/S (DK) | 2010-01-05 | — | — | US | disclosed |
| US-20060235073-A1 | Diamino-functional chalcones | LICA PHARMACEUTICALS A/S (DK) | 2006-10-19 | — | — | US | disclosed |