Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.39 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | CCR6 | P51684 | 1/20 | 0.37 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3690405 | 0.86 | ALDH1A1 (0.40) | ALDH1A1SLC6A2SLC6A3KMT2ATDP1 | |
| SCHEMBL1812242 | 0.85 | ALDH1A1 (0.49) | ALDH1A1SLC6A2SLC6A3KMT2ATDP1 | |
| SCHEMBL5229233 | 0.85 | ALDH1A1 (0.49) | ALDH1A1SLC6A2SLC6A3KMT2ATDP1 | |
| SCHEMBL10515353 | 0.85 | ALDH1A1 (0.49) | ALDH1A1SLC6A2SLC6A3KMT2ATDP1 | |
| SCHEMBL11059329 | 0.80 | ALDH1A1 (0.47) | ALDH1A1SLC6A2SLC6A3KMT2ATDP1 | |
| SCHEMBL7448004 | 0.79 | PPARG (0.44) | ALDH1A1SLC6A2SLC6A3KMT2ATDP1 | |
| SCHEMBL7448000 | 0.79 | PPARG (0.44) | ALDH1A1SLC6A2SLC6A3KMT2ATDP1 | |
| SCHEMBL7627852 | 0.77 | LMNA (0.47) | ALDH1A1SLC6A2SLC6A3KMT2ATDP1 | |
| SCHEMBL10556602 | 0.77 | ALDH1A1 (0.46) | ALDH1A1SLC6A2SLC6A3KMT2ATDP1 | |
| SCHEMBL7564622 | 0.77 | ALDH1A1 (0.46) | ALDH1A1SLC6A2SLC6A3KMT2ATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7838645-B2 | comprising antibodies that specifically bind caspase-8 as inhibitors; cancer; activation of the receptor-interacting protein (RIP, a serine-threonine kinase) and Jun N-terminal kinase induce cell death with the morphology of autophagy | UNIVERSITY OF MARYLAND COLLEGE PARK (US) | 2010-11-23 | — | — | US | disclosed |
| US-20050276809-A1 | comprising antibodies that specifically bind caspase-8 as inhibitors; cancer; activation of the receptor-interacting protein (RIP, a serine-threonine kinase) and Jun N-terminal kinase induce cell death with the morphology of autophagy | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2005-12-15 | — | — | US | disclosed |