Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIK1 | P39086 | 5/20 | 0.48 |
| ▸ | GRIK2 | Q13002 | 2/20 | 0.48 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.48 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.48 |
| ▸ | SLC1A1 | P43005 | 6/20 | 0.43 |
| ▸ | SLC1A3 | P43003 | 5/20 | 0.42 |
| ▸ | SLC1A2 | P43004 | 5/20 | 0.42 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
| ▸ | SLC7A11 | Q9UPY5 | 1/20 | 0.39 |
| ▸ | GGT1 | P19440 | 4/20 | 0.39 |
| ▸ | LTA4H | P09960 | 1/20 | 0.39 |
| ▸ | GRIA4 | P48058 | 2/20 | 0.38 |
| ▸ | GRIK3 | Q13003 | 2/20 | 0.38 |
| ▸ | GRIK5 | Q16478 | 2/20 | 0.38 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14344224 | 0.78 | GRIK1 (0.50) | GRIK1GRIK2GRM1GRM2SLC1A1 | |
| SCHEMBL22769505 | 0.78 | GRIK1 (0.50) | GRIK1GRIK2GRM1GRM2SLC1A1 | |
| SCHEMBL8353811 | 0.78 | GRIK1 (0.50) | GRIK1GRIK2GRM1GRM2SLC1A1 | |
| SCHEMBL9438438 | 0.77 | GRIK1 (0.48) | GRIK1GRIK2GRM1GRM2SLC1A1 | |
| SCHEMBL359953 | 0.76 | SLC1A1 (0.45) | GRIK1GRIK2GRM1GRM2SLC1A1 | |
| SCHEMBL24667461 | 0.75 | GRIK1 (0.48) | GRIK1GRIK2GRM1GRM2SLC1A1 | |
| SCHEMBL10596071 | 0.75 | FOLH1 (0.48) | GRIK1GRIK2GRM1GRM2SLC1A1 | |
| SCHEMBL12906559 | 0.75 | GRIK1 (0.48) | GRIK1GRIK2GRM1GRM2SLC1A1 | |
| SCHEMBL9684668 | 0.75 | FOLH1 (0.48) | GRIK1GRIK2GRM1GRM2SLC1A1 | |
| SCHEMBL10618897 | 0.74 | PTGS1 (0.55) | GRIK1GRIK2GRM1GRM2SLC1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 99 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3334498-B1 | METHODS OF TREATING VOLUME DEPLETION AND KIDNEY INJURY | UNIV COLUMBIA (US) | 2023-06-07 | — | — | EP | disclosed |
| US-11119104-B2 | Methods of treating volume depletion and kidney injury | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2021-09-14 | — | — | US | disclosed |
| EP-3334498-A1 | METHODS OF TREATING VOLUME DEPLETION AND KIDNEY INJURY | The Trustees of Columbia University in the City of New York (US) | 2018-06-20 | — | — | EP | disclosed |
| EP-2593472-B1 | ANCESTRAL PROTEINS | UNIV COLUMBIA (US) | 2018-05-16 | — | — | EP | disclosed |
| US-9880088-B2 | Force-clamp spectrometer with functionalized cantilever tip | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2018-01-30 | — | — | US | disclosed |
| US-20180016562-A1 | ANCESTRAL PROTEINS | NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR | 2018-01-18 | — | — | US | disclosed |
| US-9682123-B2 | Methods of treating metabolic disease | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2017-06-20 | — | — | US | disclosed |
| WO-2017027858-A1 | METHODS OF TREATING VOLUME DEPLETION AND KIDNEY INJURY | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2017-02-16 | — | — | WO | disclosed |
| US-20150190466-A1 | METHODS OF TREATING METABOLIC DISEASE | NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR | 2015-07-09 | — | — | US | disclosed |
| US-20130252307-A1 | ANCESTRAL PROTEINS | GEORGIA TECH RESEARCH CORPORATION (US) | 2013-09-26 | — | — | US | disclosed |
| WO-2003020899-A2 | COMPOSITIONS AND METHODS RELATING TO LUNG SPECIFIC GENES AND PROTEINS | DIADEXUS, INC. (US) | 2003-03-13 | — | — | WO | disclosed |
| WO-2003020953-A2 | COMPOSITIONS AND METHODS RELATING TO COLON SPECIFIC GENES AND PROTEINS | DIADEXUS, INC. (US) | 2003-03-13 | — | — | WO | disclosed |
| WO-2003020897-A2 | COMPOSITIONS AND METHODS RELATING TO OVARY SPECIFIC GENES AND PROTEINS | DIADEXUS, INC. (US) | 2003-03-13 | — | — | WO | disclosed |
| WO-2003020934-A1 | COMPOSITIONS AND METHODS RELATING TO COLON SPECIFIC GENES AND PROTEINS | DIADEXUS, INC. (US) | 2003-03-13 | — | — | WO | disclosed |
| WO-2003020900-A2 | COMPOSITIONS AND METHODS RELATING TO BREAST SPECIFIC GENES AND PROTEINS | DIADEXUS, INC. (US) | 2003-03-13 | — | — | WO | disclosed |
| WO-2003020901-A2 | COMPOSITIONS AND METHODS RELATING TO PROSTATE SPECIFIC GENES AND PROTEINS | DIADEXUS, INC. (US) | 2003-03-13 | — | — | WO | disclosed |
| US-20020102610-A1 | Automated identification of peptides | OXFORD GLYCOSCIENCES (UK) LTD. (GB) | 2002-08-01 | — | — | US | disclosed |
| US-20020055186-A1 | Detection of peptides | OXFORD GLYCOSCIENCES (UK) LTD. | 2002-05-09 | — | — | US | disclosed |
| WO-2002025287-A2 | DETECTION OF PEPTIDES | OXFORD GLYCOSCIENCES (UK) LTD. (GB) | 2002-03-28 | — | — | WO | disclosed |
| WO-2002021139-A2 | AUTOMATED IDENTIFICATION OF PEPTIDES | OXFORD GLYCOSCIENCES (UK) LTD. (GB) | 2002-03-14 | — | — | WO | disclosed |