Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Milrinone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3A known ✓ | Q14432 | 12/20 | 1.00 |
| ▸ | PDE3B | Q13370 | 11/20 | 1.00 |
| ▸ | HPGD | P15428 | 3/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 1.00 |
| ▸ | PDE4A | P27815 | 3/20 | 1.00 |
| ▸ | BLM | P54132 | 2/20 | 1.00 |
| ▸ | PDE4B | Q07343 | 2/20 | 1.00 |
| ▸ | PDE4C | Q08493 | 2/20 | 1.00 |
| ▸ | PDE4D | Q08499 | 2/20 | 1.00 |
| ▸ | PDE5A | O76074 | 1/20 | 1.00 |
| ▸ | LMNA | P02545 | 1/20 | 1.00 |
| ▸ | TSHR | P16473 | 1/20 | 1.00 |
| ▸ | PTGS1 | P23219 | 1/20 | 1.00 |
| ▸ | CYP2C19 | P33261 | 1/20 | 1.00 |
| ▸ | GALR3 | O60755 | 1/20 | 0.73 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.73 |
| ▸ | GAA | P10253 | 1/20 | 0.73 |
| ▸ | PDE2A | O00408 | 1/20 | 0.65 |
| ▸ | PDE1A | P54750 | 1/20 | 0.65 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Milrinone SCHEMBL9309054 | 1.00 | PDE3A (1.00) | PDE3APDE3BHPGDKDM4EPDE4A | |
| Milrinone SCHEMBL9247989 | 1.00 | PDE3A (1.00) | PDE3APDE3BHPGDKDM4EPDE4A | |
| Milrinone SCHEMBL9301167 | 1.00 | PDE3A (1.00) | PDE3APDE3BHPGDKDM4EPDE4A | |
| Milrinone SCHEMBL28184205 | 0.98 | PDE3A (0.97) | PDE3APDE3BHPGDKDM4EPDE4A | |
| Milrinone SCHEMBL1160021 | 0.97 | PDE3A (0.94) | PDE3APDE3BHPGDKDM4EPDE4A | |
| Milrinone SCHEMBL9132559 | 0.97 | PDE3A (0.94) | PDE3APDE3BHPGDKDM4EPDE4A | |
| Milrinone SCHEMBL3463564 | 0.89 | PDE3A (0.79) | PDE3APDE3BHPGDKDM4EPDE4A | |
| Milrinone SCHEMBL9872022 | 0.89 | PDE3A (0.79) | PDE3APDE3BHPGDKDM4EPDE4A | |
| Milrinone SCHEMBL8578994 | 0.89 | PDE3A (0.79) | PDE3APDE3BHPGDKDM4EPDE4A | |
| Milrinone SCHEMBL42338 | 0.89 | PDE3A (0.79) | PDE3APDE3BHPGDKDM4EPDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 22004 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-120504685-B | Prodrug structure with ROS signal response performance, and preparation method and application thereof | Rehabilitation University (CN) | 2026-05-26 | — | — | CN | claimed |
| EP-4736841-A1 | A MUCOADHESIVE LAYER FOR BUCCAL ADMINISTRATION OF AN ACTIVE PHARMACEUTICAL INGREDIENT | IQ medical GmbH (DE) | 2026-05-06 | — | — | EP | claimed |
| EP-4704971-A1 | GAMMA STIMULATION AND NEUROMODULATOR COMBINATION THERAPY | Cognito Therapeutics, Inc. (US) | 2026-03-11 | — | — | EP | claimed |
| EP-4691556-A2 | HUMANIZED ANTI-ACTH ANTIBODIES AND USE THEREOF | H. Lundbeck A/S (DK) | 2026-02-11 | — | — | EP | claimed |
| EP-4058037-B1 | FIBROBLAST-BASED THERAPY FOR TREATMENT AND PREVENTION OF STROKE | SPINALCYTE LLC (US) | 2026-01-28 | — | — | EP | claimed |
| US-12428475-B2 | Humanized anti-ACTH antibodies and use thereof | H. LUNDBECK A/S (DK) | 2025-09-30 | — | — | US | claimed |
| US-20250285722-A1 | SHOCK DETECTION AND MANAGEMENT SYSTEM | Nihon Kohden Digital Health Solutions, Inc. (US) | 2025-09-11 | — | — | US | claimed |
| EP-4032401-B1 | METHOD FOR PRODUCING AN ORGAN CARE SOLUTION FOR EX-VIVO MACHINE PERFUSION OF DONOR LUNGS | TRANSMEDICS INC (US) | 2025-09-10 | — | — | EP | claimed |
| US-20250275952-A1 | 4-METHYLSULFONYL-SUBSTITUTED PIPERIDINE UREA COMPOUNDS | MYOKARDIA INC (US) | 2025-09-04 | — | — | US | claimed |
| US-20250228824-A1 | COMPOSITIONS AND METHODS FOR INHIBITION OF ITO AS TREATMENT FOR THE J WAVE SYNDROMES AND HYPOTHERMIA | SIMON FRASER UNIVERSITY (CA) | 2025-07-17 | — | — | US | claimed |
| US-4868182-A | HYPOTENSIVE AND CARDIOTONIC, SYNERGISTIC | MERRELL DOW PHARMACEUTICALS INC. (US) | 1989-09-19 | — | — | US | claimed |
| US-4806361-A | THREE ADMIXED POLYMERS SOLUBLE AT DIFFERENT PHS | STERLING DRUG INC. (US) | 1989-02-21 | — | — | US | claimed |
| US-4783337-A | Osmotic system comprising plurality of members for dispensing drug | ALZA CORPORATION (US) | 1988-11-08 | — | — | US | claimed |
| US-4650806-A | Cardiotonic 5-(heterylcarbonyl)-pyridones | STERLING DRUG INC. (US) | 1987-03-17 | — | — | US | claimed |
| EP-0075116-B1 | PROCESS FOR PREPARING 1,2-DIHYDRO-6-METHYL-2-OXO-5-(PYRIDINYL)NICOTINONITRILES | STERLING DRUG INC. (US) | 1985-05-22 | — | — | EP | claimed |
| US-4469871-A | Process for preparing 2-(lower-alkoxy)-1-(pyridinyl) ethenyl lower-alkyl ketones | STERLING DRUG INC. (US) | 1984-09-04 | — | — | US | claimed |
| US-4413127-A | Preparation of 1,2-dihydro-6-(lower alkyl)-2-oxo-5-(pyridinyl)nicotinonitriles | STERLING DRUG INC. (US) | 1983-11-01 | — | — | US | claimed |
| EP-0075116-A1 | Process for preparing 1,2-dihydro-6-methyl-2-oxo-5-(pyridinyl)nicotinonitriles | STERLING DRUG INC. (US) | 1983-03-30 | — | — | EP | claimed |
| US-4347363-A | Process for preparing 1,2-dihydro-6-methyl-2-oxo-5-(pyridinyl)nicotinonitriles | STERLING DRUG INC. (US) | 1982-08-31 | — | — | US | claimed |
| US-4313951-A | 3-Substituted-6-(lower-alkyl)-5-(pyridinyl)-2(1H)-pyridinones, their cardiotonic use and intermediates therefor | STERLING DRUG INC. (US) | 1982-02-02 | — | — | US | claimed |