Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Milrinone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3A known ✓ | Q14432 | 12/20 | 1.00 |
| ▸ | PDE3B | Q13370 | 11/20 | 1.00 |
| ▸ | HPGD | P15428 | 3/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 1.00 |
| ▸ | PDE4A | P27815 | 3/20 | 1.00 |
| ▸ | BLM | P54132 | 2/20 | 1.00 |
| ▸ | PDE4B | Q07343 | 2/20 | 1.00 |
| ▸ | PDE4C | Q08493 | 2/20 | 1.00 |
| ▸ | PDE4D | Q08499 | 2/20 | 1.00 |
| ▸ | PDE5A | O76074 | 1/20 | 1.00 |
| ▸ | LMNA | P02545 | 1/20 | 1.00 |
| ▸ | TSHR | P16473 | 1/20 | 1.00 |
| ▸ | PTGS1 | P23219 | 1/20 | 1.00 |
| ▸ | CYP2C19 | P33261 | 1/20 | 1.00 |
| ▸ | GALR3 | O60755 | 1/20 | 0.73 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.73 |
| ▸ | GAA | P10253 | 1/20 | 0.73 |
| ▸ | PDE2A | O00408 | 1/20 | 0.65 |
| ▸ | PDE1A | P54750 | 1/20 | 0.65 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Milrinone SCHEMBL36947 | 1.00 | PDE3A (1.00) | PDE3APDE3BHPGDKDM4EPDE4A | |
| Milrinone SCHEMBL9309054 | 1.00 | PDE3A (1.00) | PDE3APDE3BHPGDKDM4EPDE4A | |
| Milrinone SCHEMBL9247989 | 1.00 | PDE3A (1.00) | PDE3APDE3BHPGDKDM4EPDE4A | |
| Milrinone SCHEMBL28184205 | 0.98 | PDE3A (0.97) | PDE3APDE3BHPGDKDM4EPDE4A | |
| Milrinone SCHEMBL1160021 | 0.97 | PDE3A (0.94) | PDE3APDE3BHPGDKDM4EPDE4A | |
| Milrinone SCHEMBL9132559 | 0.97 | PDE3A (0.94) | PDE3APDE3BHPGDKDM4EPDE4A | |
| Milrinone SCHEMBL3463564 | 0.89 | PDE3A (0.79) | PDE3APDE3BHPGDKDM4EPDE4A | |
| Milrinone SCHEMBL9872022 | 0.89 | PDE3A (0.79) | PDE3APDE3BHPGDKDM4EPDE4A | |
| Milrinone SCHEMBL8578994 | 0.89 | PDE3A (0.79) | PDE3APDE3BHPGDKDM4EPDE4A | |
| Milrinone SCHEMBL42338 | 0.89 | PDE3A (0.79) | PDE3APDE3BHPGDKDM4EPDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3392307-B1 | PROCESS FOR PRODUCING POLYACETAL RESIN COMPOSITION | POLYPLASTICS CO (JP) | 2020-10-28 | — | — | EP | disclosed |
| US-10577496-B2 | Process for producing polyacetal resin composition | POLYPLASTICS CO., LTD. (JP) | 2020-03-03 | — | — | US | disclosed |
| US-20190241732-A1 | PROCESS FOR PRODUCING POLYACETAL RESIN COMPOSITION | POLYPLASTICS CO., LTD. (JP) | 2019-08-08 | — | — | US | disclosed |
| EP-3392307-A1 | PROCESS FOR PRODUCING POLYACETAL RESIN COMPOSITION | Polyplastics Co., Ltd. (JP) | 2018-10-24 | — | — | EP | disclosed |
| US-5356941-A | Adding peroxide crosslinking agent to form irreversible covelant bonds between polymer radicals; durability, impact strength | LISCO, INC. (US) | 1994-10-18 | — | — | US | disclosed |
| US-4888174-A | Insecticidal polymeric compositions | THE DOW CHEMICAL COMPANY (US) | 1989-12-19 | — | — | US | disclosed |