Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Milrinone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3A known ✓ | Q14432 | 12/20 | 0.94 |
| ▸ | PDE3B | Q13370 | 11/20 | 0.94 |
| ▸ | HPGD | P15428 | 3/20 | 0.94 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.94 |
| ▸ | PDE4A | P27815 | 3/20 | 0.94 |
| ▸ | BLM | P54132 | 2/20 | 0.94 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.94 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.94 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.94 |
| ▸ | PDE5A | O76074 | 1/20 | 0.94 |
| ▸ | LMNA | P02545 | 1/20 | 0.94 |
| ▸ | TSHR | P16473 | 1/20 | 0.94 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.94 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.94 |
| ▸ | GALR3 | O60755 | 1/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.69 |
| ▸ | GAA | P10253 | 1/20 | 0.69 |
| ▸ | PDE2A | O00408 | 1/20 | 0.62 |
| ▸ | PDE1A | P54750 | 1/20 | 0.62 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Milrinone SCHEMBL36947 | 0.97 | PDE3A (1.00) | PDE3APDE3BHPGDKDM4EPDE4A | |
| Milrinone SCHEMBL9247989 | 0.97 | PDE3A (1.00) | PDE3APDE3BHPGDKDM4EPDE4A | |
| Milrinone SCHEMBL9301167 | 0.97 | PDE3A (1.00) | PDE3APDE3BHPGDKDM4EPDE4A | |
| Milrinone SCHEMBL9309054 | 0.97 | PDE3A (1.00) | PDE3APDE3BHPGDKDM4EPDE4A | |
| Milrinone SCHEMBL28184205 | 0.96 | PDE3A (0.97) | PDE3APDE3BHPGDKDM4EPDE4A | |
| Milrinone SCHEMBL9132559 | 0.94 | PDE3A (0.94) | PDE3APDE3BHPGDKDM4EPDE4A | |
| Milrinone SCHEMBL1921829 | 0.90 | PDE3A (0.77) | PDE3APDE3BHPGDKDM4EPDE4A | |
| Milrinone SCHEMBL9872022 | 0.89 | PDE3A (0.79) | PDE3APDE3BHPGDKDM4EPDE4A | |
| Milrinone SCHEMBL8578994 | 0.89 | PDE3A (0.79) | PDE3APDE3BHPGDKDM4EPDE4A | |
| Milrinone SCHEMBL3463564 | 0.86 | PDE3A (0.79) | PDE3APDE3BHPGDKDM4EPDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 40 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11752751-B2 | Bonding method to attach ethylene-based polymer foam with vulcanized rubber | DOW GLOBAL TECHNOLOGIES LLC (US) | 2023-09-12 | — | — | US | disclosed |
| US-11613636-B2 | Polymer blends for use in multilayer structure and multilayer structures comprising the same | DOW GLOBAL TECHNOLOGIES LLC (US) | 2023-03-28 | — | — | US | disclosed |
| US-20220032596-A1 | Bonding Method to Attach Ethylene-Based Polymer Foam with Vulcanized Rubber | DOW GLOBAL TECHNOLOGIES LLC | 2022-02-03 | — | — | US | disclosed |
| EP-3568436-B1 | POLYMER BLENDS FOR USE IN MULTILAYER STRUCTURE AND MULTILAYER STRUCTURES COMPRISING SAME | DOW GLOBAL TECHNOLOGIES LLC (US) | 2021-11-24 | — | — | EP | disclosed |
| US-11015092-B2 | Adhesive for binding polyolefin membrane to glass fibers | DOW GLOBAL TECHNOLOGIES LLC (US) | 2021-05-25 | — | — | US | disclosed |
| US-20200087497-A1 | POLYMER BLENDS FOR USE IN MULTILAYER STRUCTURE AND MULTILAYER STRUCTURES COMPRISING THE SAME | DOW GLOBAL TECHNOLOGIES LLC | 2020-03-19 | — | — | US | disclosed |
| US-20190203084-A1 | Adhesive for Binding Polyolefin Membrane to Glass Fibers | DOW GLOBAL TECHNOLOGIES LLC | 2019-07-04 | — | — | US | disclosed |
| EP-2464686-B1 | THERMOPLASTIC ELASTOMER COMPOSITIONS COMPRISING INTUMESCENT FLAME RETARDANTS AND NON-PHOSPHOROUS-BASED FLAME RETARDANT SYNERGISTS | UNION CARBIDE CHEM PLASTIC (US) | 2019-05-08 | — | — | EP | disclosed |
| US-10266703-B2 | Polyolefin polyols as surface modifying agents | DOW GLOBAL TECHNOLOGIES LLC (US) | 2019-04-23 | — | — | US | disclosed |
| EP-3227365-B1 | POLYOLEFIN POLYOLS AS SURFACE MODIFYING AGENTS | DOW GLOBAL TECHNOLOGIES LLC (US) | 2019-01-23 | — | — | EP | disclosed |
| EP-2464686-A1 | THERMOPLASTIC ELASTOMER COMPOSITIONS COMPRISING INTUMESCENT FLAME RETARDANTS AND NON-PHOSPHOROUS-BASED FLAME RETARDANT SYNERGISTS | Union Carbide Chemicals & Plastics Technology LLC (US) | 2012-06-20 | — | — | EP | disclosed |
| EP-2459632-A1 | FLAME RETARDANT THERMOPLASTIC ELASTOMER | Dow Global Technologies LLC (formerly Known As Dow Global Technologies Inc.) (US) | 2012-06-06 | — | — | EP | disclosed |
| US-20120132457-A1 | Flame Retardant Thermoplastic Elastomer | DOW CHEMICAL (CHINA) COMPANY LIMITED (CN) | 2012-05-31 | — | — | US | disclosed |
| US-20120125657-A1 | Thermoplastic Elastomer Compositions Comprising Intumescent Flame Retardants and Non-Phosphorous-Based Flame Retardant Synergists | UNION CARBIDE CORPORATION | 2012-05-24 | — | — | US | disclosed |
| WO-2011159435-A1 | POLYURETHANE/POLYOLEFIN BLENDS WITH IMPROVED STRAIN AND SCRATCH WHITENING PERFORMANCE | UNION CARBIDE CHEMICALS & PLASTICS TECHNOLOGY LLC (US) | 2011-12-22 | — | — | WO | disclosed |
| WO-2011127651-A1 | STYRENIC BLOCK COPOLYMER-BASED COMPOSITION WITH ENHANCED FLAME-RETARDANT PROPERTIES | DOW GLOBAL TECHNOLOGIES LLC (US) | 2011-10-20 | — | — | WO | disclosed |
| WO-2011069301-A1 | THERMOPLASTIC POLYMER BLENDS COMPRISING CROSSLINKED POLAR OLEFIN POLYMERS IN A THERMOPLASTIC POLYURETHANE MATRIX | DOW GLOBAL TECHNOLOGIES LLC. (US) | 2011-06-16 | — | — | WO | disclosed |
| WO-2011019536-A1 | THERMOPLASTIC ELASTOMER COMPOSITIONS COMPRISING INTUMESCENT FLAME RETARDANTS AND NON-PHOSPHOROUS-BASED FLAME RETARDANT SYNERGISTS | UNION CARBIDE CHEMICALS & PLASTICS TECHNOLOGY LLC (US) | 2011-02-17 | — | — | WO | disclosed |
| WO-2011011921-A1 | FLAME RETARDANT THERMOPLASTIC ELASTOMER | DOW GLOBAL TECHNOLOGIES INC. (US) | 2011-02-03 | — | — | WO | disclosed |
| EP-0915660-B1 | PACKAGE HAVING COOKED FOOD PRODUCT PACKAGED IN FILM HAVING FOOD ADHESION LAYER CONTAINING HIGH VICAT SOFTENING POINT OLEFIN/ACRYLIC ACID COPOLYMER | CRYOVAC INC (US) | 2002-09-11 | — | — | EP | disclosed |