Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Milrinone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3A known ✓ | Q14432 | 9/20 | 0.79 |
| ▸ | PDE3B | Q13370 | 8/20 | 0.79 |
| ▸ | HPGD | P15428 | 3/20 | 0.79 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.79 |
| ▸ | PDE4A | P27815 | 3/20 | 0.79 |
| ▸ | BLM | P54132 | 2/20 | 0.79 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.79 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.79 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.79 |
| ▸ | PDE5A | O76074 | 1/20 | 0.79 |
| ▸ | LMNA | P02545 | 1/20 | 0.79 |
| ▸ | TSHR | P16473 | 1/20 | 0.79 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.79 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.79 |
| ▸ | GALR3 | O60755 | 1/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.62 |
| ▸ | GAA | P10253 | 1/20 | 0.62 |
| ▸ | PDE2A | O00408 | 1/20 | 0.55 |
| ▸ | PDE1A | P54750 | 1/20 | 0.55 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Milrinone SCHEMBL1160021 | 0.89 | PDE3A (0.94) | PDE3APDE3BHPGDKDM4EPDE4A | |
| Milrinone SCHEMBL9309054 | 0.89 | PDE3A (1.00) | PDE3APDE3BHPGDKDM4EPDE4A | |
| Milrinone SCHEMBL36947 | 0.89 | PDE3A (1.00) | PDE3APDE3BHPGDKDM4EPDE4A | |
| Milrinone SCHEMBL9247989 | 0.89 | PDE3A (1.00) | PDE3APDE3BHPGDKDM4EPDE4A | |
| Milrinone SCHEMBL9301167 | 0.89 | PDE3A (1.00) | PDE3APDE3BHPGDKDM4EPDE4A | |
| Milrinone SCHEMBL8578994 | 0.88 | PDE3A (0.79) | PDE3APDE3BHPGDKDM4EPDE4A | |
| Milrinone SCHEMBL28184205 | 0.87 | PDE3A (0.97) | PDE3APDE3BHPGDKDM4EPDE4A | |
| Milrinone SCHEMBL1921829 | 0.87 | PDE3A (0.77) | PDE3APDE3BHPGDKDM4EPDE4A | |
| Milrinone SCHEMBL9132559 | 0.86 | PDE3A (0.94) | PDE3APDE3BHPGDKDM4EPDE4A | |
| Milrinone SCHEMBL3463564 | 0.86 | PDE3A (0.79) | PDE3APDE3BHPGDKDM4EPDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5068289-A | Glass reinforced polymer blend of carbon monoxide-ethylene copolymer, a polyamide and an olefin copolymer | SHELL OIL COMPANY (US) | 1991-11-26 | — | — | US | disclosed |