Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | LTA4H | P09960 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.39 |
| ▸ | TSHR | P16473 | 4/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | HBB | P68871 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | TNF | P01375 | 1/20 | 0.37 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.37 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.37 |
| ▸ | FDPS | P14324 | 1/20 | 0.36 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2120550 | 0.84 | FDPS (0.45) | LTA4HCYP1A2ALDH1A1CYP2C9TSHR | |
| SCHEMBL28340215 | 0.82 | FDPS (0.44) | LTA4HCYP1A2ALDH1A1CYP2C9TSHR | |
| SCHEMBL7196401 | 0.80 | TDP1 (0.58) | TDP1HTTLMNAMEN1KMT2A | |
| SCHEMBL7797362 | 0.78 | FDPS (0.37) | LTA4HCYP1A2ALDH1A1CYP2C9TSHR | |
| SCHEMBL4706469 | 0.77 | LTA4H (0.38) | LTA4HCYP1A2ALDH1A1CYP2C9TSHR | |
| SCHEMBL27714273 | 0.77 | CYP1A2 (0.46) | LTA4HCYP1A2ALDH1A1CYP2C9TSHR | |
| SCHEMBL27783128 | 0.74 | FDPS (0.39) | LTA4HCYP1A2ALDH1A1CYP2C9TSHR | |
| SCHEMBL27734755 | 0.72 | FDPS (0.40) | LTA4HCYP1A2ALDH1A1CYP2C9TSHR | |
| SCHEMBL27558464 | 0.71 | FDPS (0.37) | LTA4HCYP1A2ALDH1A1CYP2C9TSHR | |
| SCHEMBL6055010 | 0.70 | FDPS (0.39) | LTA4HCYP1A2ALDH1A1CYP2C9TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140364451-A1 | TROPINOL ESTERS AND RELATED COMPOUNDS TO PROMOTE NORMAL PROCESSING OF APP | BUCK INSTITUTE FOR RESEARCH ON AGING (US) | 2014-12-11 | — | — | US | claimed |
| WO-2013019901-A2 | TROPINOL ESTERS AND RELATED COMPOUNDS TO PROMOTE NORMAL PROCESSING OF APP | BUCK INSTITUTE FOR RESEARCH ON AGING (US) | 2013-02-07 | — | — | WO | claimed |
| US-11325904-B2 | Tropinol esters and related compounds to promote normal processing of APP | BUCK INSTITUTE FOR RESEARCH ON AGING (US) | 2022-05-10 | — | — | US | disclosed |
| EP-2593455-B1 | PURINE COMPOUNDS SELECTIVE FOR I3 P110 DELTA, AND METHODS OF USE | HOFFMANN LA ROCHE (CH) | 2015-03-18 | — | — | EP | disclosed |
| US-20140364451-A1 | TROPINOL ESTERS AND RELATED COMPOUNDS TO PROMOTE NORMAL PROCESSING OF APP | BUCK INSTITUTE FOR RESEARCH ON AGING (US) | 2014-12-11 | — | — | US | disclosed |
| EP-2593455-A1 | PURINE COMPOUNDS SELECTIVE FOR I3 P110 DELTA, AND METHODS OF USE | F.HOFFMANN-LA ROCHE AG (CH) | 2013-05-22 | — | — | EP | disclosed |
| WO-2013019901-A2 | TROPINOL ESTERS AND RELATED COMPOUNDS TO PROMOTE NORMAL PROCESSING OF APP | BUCK INSTITUTE FOR RESEARCH ON AGING (US) | 2013-02-07 | — | — | WO | disclosed |
| US-8293736-B2 | Purine compounds selective for PI3K P110 delta, and methods of use | F. HOFFMANN LA ROCHE AG (CH) | 2012-10-23 | — | — | US | disclosed |
| WO-2012007493-A1 | PURINE COMPOUNDS SELECTIVE FOR ΡI3Κ P110 DELTA, AND METHODS OF USE | F. HOFFMANN-LA ROCHE AG (CH) | 2012-01-19 | — | — | WO | disclosed |
| US-20120015931-A1 | PURINE COMPOUNDS SELECTIVE FOR PI3K P110 DELTA, AND METHODS OF USE | F. HOFFMANN-LA ROCHE AG (CH) | 2012-01-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140364451-A1 | TROPINOL ESTERS AND RELATED COMPOUNDS TO PROMOTE NORMAL PROCESSING OF APP | APP, BACE1, APBA1 | TDP1 267/4885HTT 196/4885LTA4H 1242/4885 |
| US-20120015931-A1 | PURINE COMPOUNDS SELECTIVE FOR PI3K P110 DELTA, AND METHODS OF USE | PIK3CA, PIK3CD, PIK3CG | TDP1 181/4885HTT 3119/4885LTA4H 2306/4885 |
| US-11325904-B2 | Tropinol esters and related compounds to promote normal processing of APP | APP, BACE1, APBA1 | TDP1 267/4885HTT 196/4885LTA4H 1242/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.