SCHEMBL369527

SCHEMBL369527

COc1ccc(Cn2cc(C=CC=O)c(C(C)(C)O)n2)cc1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
AADAT Q8N5Z0 1/20 0.39
HSP90AA1 P07900 2/20 0.39
HSP90AB1 P08238 2/20 0.39
CMA1 P23946 1/20 0.39
PDE1A P54750 1/20 0.39
PDE1B Q01064 1/20 0.39
PDE1C Q14123 1/20 0.39
RAB9A P51151 3/20 0.37
L3MBTL1 Q9Y468 2/20 0.37
DUSP3 P51452 1/20 0.37
SMN1; SMN2 Q16637 1/20 0.37
MEN1 O00255 2/20 0.36
NPC1 O15118 2/20 0.36
KMT2A Q03164 2/20 0.36
CACNA1G O43497 1/20 0.36
CACNA1H O95180 1/20 0.36
CACNA1I Q9P0X4 1/20 0.36
HDAC1 Q13547 2/20 0.35
HDAC3 O15379 1/20 0.35
HDAC4 P56524 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL370873 0.76 AADAT (0.39) AADATHSP90AA1HSP90AB1CMA1PDE1B
SCHEMBL369528 0.76 KMT2A (0.43) AADATHSP90AA1HSP90AB1PDE1APDE1B
SCHEMBL3696651 0.75 GAA (0.46) AADATHSP90AA1HSP90AB1CMA1RAB9A
SCHEMBL370600 0.74 KLKB1 (0.43) AADATHSP90AA1HSP90AB1PDE1APDE1B
SCHEMBL26106761 0.71 RAB9A (0.50) AADATHSP90AA1HSP90AB1CMA1RAB9A
SCHEMBL21796563 0.70 RAB9A (0.49) AADATHSP90AA1HSP90AB1CMA1RAB9A
SCHEMBL21518857 0.69 SMN1; SMN2 (0.45) AADATRAB9AL3MBTL1DUSP3SMN1; SMN2
SCHEMBL26622753 0.69 L3MBTL1 (0.49) HSP90AA1HSP90AB1CMA1PDE1APDE1B
SCHEMBL370819 0.69 CMA1 (0.44) AADATHSP90AA1HSP90AB1CMA1RAB9A
SCHEMBL20226401 0.68 HSP90AA1 (0.45) AADATHSP90AA1HSP90AB1CMA1PDE1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2593277-A2 NOVEL FUSED PYRAZOLE DERIVATIVES AND THEIR USE AS ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS ADDEX Pharma S.A. (CH) 2013-05-22 EP disclosed
WO-2012009000-A2 NOVEL FUSED PYRAZOLE DERIVATIVES AND THEIR USE AS ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS ADDEX PHARMA S.A. (CH) 2012-01-19 WO disclosed