Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | HTR2A | P28223 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 2/20 | 0.33 |
| ▸ | HRH1 | P35367 | 2/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | APEX1 | P27695 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | CD69 | Q07108 | 1/20 | 0.33 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.33 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.33 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.33 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.33 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7385232 | 0.75 | ALDH1A1 (0.50) | ALDH1A1HTR2AKDM4EALOX15TSHR | |
| SCHEMBL6070424 | 0.75 | ALDH1A1 (0.43) | ALDH1A1HTR2AHTR2CHRH1THRB | |
| SCHEMBL6070187 | 0.71 | ALDH1A1 (0.44) | ALDH1A1GRIN2BGAAKCNH2 | |
| SCHEMBL11704517 | 0.70 | BRD4 (0.38) | ALDH1A1NPC1RAB9AGAAKCNH2 | |
| SCHEMBL11704243 | 0.69 | BRD4 (0.37) | ALDH1A1NPC1RAB9AKCNH2 | |
| SCHEMBL1206839 | 0.69 | ALDH1A1 (0.45) | ALDH1A1HTR2AKDM4ENPSR1GAA | |
| SCHEMBL13005573 | 0.68 | HTR2A (0.46) | HTR2ANPC1RAB9AHTR2CHRH1 | |
| SCHEMBL524258 | 0.68 | KMT2A (0.39) | TSHRNPSR1THRBTDP1 | |
| SCHEMBL5740020 | 0.67 | HTR2A (0.48) | ALDH1A1HTR2ATSHRHTR2CTDP1 | |
| SCHEMBL11700264 | 0.67 | BRD4 (0.42) | ALDH1A1KDM4ETSHRGAAKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7642073-B2 | Using mixture comprising modified alcohol dehydrogenase, ammonia, nicotinamide and 2-ketoacid to generate preferential amino acids | CODEXIS, INC. (US) | 2010-01-05 | — | — | US | disclosed |
| US-20080076162-A1 | Using mixture comprising modified alcohol dehydrogenase, ammonia, nicotinamide and 2-ketoacid to generate preferential amino acids | BIOCATALYTICS, INC. | 2008-03-27 | — | — | US | disclosed |
| US-7202070-B2 | Generating phenylalanine and leucine using mutant enzymatic polypeptide; generate mutant enzyme, aminate ketoacid, recover amino acids | BIOCATALYTICS, INC. (US) | 2007-04-10 | — | — | US | disclosed |
| US-20020061564-A1 | Generating phenylalanine and leucine using mutant enzymatic polypeptide; generate mutant enzyme, aminate ketoacid, recover amino acids | CODEXIS, INC. | 2002-05-23 | — | — | US | disclosed |
| WO-2002036742-A2 | METHOD FOR CHEMICAL TRANSFORMATION USING A MUTATED ENZYME | BIOCATALYTICS, INC. (US) | 2002-05-10 | — | — | WO | disclosed |